A Phase 2/3 interventional study of PRP injection and ADSTEM Inj. (Adult human mesenchymal stem cells) in Osteoarthritis Knee, sponsored by University Hospital of North Norway. Enrolling by invitation at 1 site in Norway. Open to participants aged 40 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-06-15.
Sponsored by University Hospital of North Norway · Phase 2/3, Interventional, and Treatment
The goal of this randomized clinical trial is to compare treatment for osteoarthritis in the knee using platelet rich plasma (PRP) or adipose stem cells (ADS). The main questions it aims to answer are:
Patients will be randomized into one of four treatment groups and then be followed up at 6 weeks, 12 weeks, 6 months, 1 year and 2 years after intervention. They will fill out scores and be clinically evaluated, as well as radiologically examined at inclusion and at the final check up (x-ray and MRI).
3,292 studies on the registry are indexed under Osteoarthritis, Knee; 623 are open to participants now.
This study's planned enrollment of 160 is above the median of 68 across 2,714 interventional studies indexed under Osteoarthritis, Knee.
Browse Osteoarthritis, Knee studies →University Hospital of North Norway is the lead sponsor of 152 studies on the registry; 24 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Plasma taken from the patient is centrifuged and isolated before it is injected into the patients knee.
Biological: PRP injection
Adipose tissue is taken from the patients abdominal subcutaneous fat tissue and is injected into the knee.
Biological: ADSTEM Inj. (Adult human mesenchymal stem cells)
A combination of platelet rich plasma and adipose tissue stem cells are taken from the patient and injected into the patients knee.
Biological: Injection
Saline (NaCl) is injected into the patients knee.
Biological: Saline (NaCl 0,9 %) (placebo)
Platelet rich plasma, blood from the patient that is centrifuged.
Also known as: Platelet rich plasma, PRP
Adipose tissue stem cells, from abdominal fat.
Also known as: Mesenchymal stem cells, Adipose tissue stem cells
PRP + adipose tissue stem cells
Also known as: PRP, Adipose tissue stem cells
Sterile saline injection.
Also known as: placebo, NaCl, saline
KOOS (The Knee injury and Osteoarthritis Outcome Score)
KOOS score filled out by the patient, from 0-100 where a higher score indicates worse outcomes.
Time frame: Evaluated during 2 years of follow up (6 weeks, 12 weeks, 6 months, 1 year, 2 years)
WOMAC score (Western Ontario og McMaster Universities Osteoarthritis Index)
Clinical outcome scores (WOMAC) filled out by the patient. Scale from 0-96 in total (0-4 on each question, added together). A higher score indicates a worse score.
Time frame: Evaluated during 2 years of follow up (6 weeks, 12 weeks, 6 months, 1 year, 2 years)
VAS (Visual analogue scale)
Pain score (VAS) from 0-10 where a higher score indicates worse outcomes.
Time frame: Evaluated during 2 years of follow up (6 weeks, 12 weeks, 6 months, 1 year, 2 years)
Radiological findings after treatment
Cartilage status on MRI (magnetic resonance imaging) 2 years after intervention as compared with at time of inclusion
Time frame: At inclusion and 2 years after intervention.
Plan to share: No — Only main scientists in the project will have access to IPD.
No publications or documents are linked to this record.
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Studies of the drug tested here: Platelet rich plasma
University Hospital of North Norway →