An interventional study of Mouthrinse with Coconut oil pulling and Mouthrinse with Chlorhexidine 0.12% in Halitosis, sponsored by Hue University of Medicine and Pharmacy. Completed at 1 site in Vietnam. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-21.
Sponsored by Hue University of Medicine and Pharmacy · Not applicable, Interventional, and Treatment
Goal:
The goal of this clinical trial is to evaluate the effectiveness of different oral hygiene methods (tooth brushing, tongue cleaning, and mouthwash use) in managing halitosis (bad breath) in adults. The main questions it aims to answer are:
Do oral hygiene methods (tongue cleaning, chlorhexidine mouthwash, and coconut oil mouthwash) reduce the levels of volatile sulfur compounds (VSCs) in participants' breath?
Do these methods improve self-reported and clinically assessed halitosis?
Study Design:
Researchers will compare three intervention groups:
Group I: Tongue cleaning. Group II: Chlorhexidine mouthwash. Group III: Coconut oil mouthwash.
After one week, Groups II and III will add tongue cleaning, and in the third week, Groups I and III will use chlorhexidine mouthwash to ensure equitable benefits.
Participants will:
Follow their assigned oral hygiene regimen daily for 2 weeks. Receive the halitosis assessments at baseline, 1 week, and 2 weeks post-intervention, including organoleptic testing and volatile sulfur compounds level measurements using the OralChroma device.
Complete self-reported assessments of halitosis using a visual analog scale (VAS).
Diagnosis of Halitosis:
Hydrogen sulfide (H2S) > 1.5 ng/10 ml, OR Methyl mercaptan (CH3SH) > 0.5 ng/10 ml.
Exclusion Criteria:
Dental Conditions:
Other: Mouthrinse with Chlorhexidine 0.12%
Other: Mouthrinse with Coconut oil pulling
Using mouth rinse with coconut oil for two weeks to treat halitosis
Using mouthrinse with 0.12% chlorhexidine for two weeks to treat halitosis
Reduction in Volatile Sulfur Compounds (VSCs) Levels
Measurement of VSC levels (hydrogen sulfide \[H2S\] and methyl mercaptan \[CH3SH\]) in participants' breath using the OralChroma device. Lower VSC levels indicate improved halitosis control.
Time frame: Baseline, 1 week post-intervention, and 2 weeks post-intervention.
Improvement in Organoleptic Test (OT) Scores
Clinical assessment of halitosis severity using the Organoleptic Test, where a trained examiner scores breath odor on a scale of 0 (no odor) to 5 (extremely strong odor). A reduction in OT scores indicates improvement in halitosis.
Time frame: Baseline, 1 week post-intervention, and 2 weeks post-intervention.
Improvement in Self-Reported Halitosis Severity
Participants' self-assessment of halitosis severity using a visual analog scale (VAS) ranging from 0 (no bad breath) to 100 (very severe bad breath). Lower scores indicate improved self-perceived halitosis.
Time frame: Baseline, 1 week post-intervention, and 2 weeks post-intervention.
This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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Hue University of Medicine and Pharmacy