An interventional study of Mouthrinse with Coconut oil pulling and Mouthrinse with Chlorhexidine 0.12% in Halitosis, sponsored by Hue University of Medicine and Pharmacy. Completed at 1 site in Vietnam. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-21.
Sponsored by Hue University of Medicine and Pharmacy · Not applicable, Interventional, and Treatment
Goal:
The goal of this clinical trial is to evaluate the effectiveness of different oral hygiene methods (tooth brushing, tongue cleaning, and mouthwash use) in managing halitosis (bad breath) in adults. The main questions it aims to answer are:
Do oral hygiene methods (tongue cleaning, chlorhexidine mouthwash, and coconut oil mouthwash) reduce the levels of volatile sulfur compounds (VSCs) in participants' breath?
Do these methods improve self-reported and clinically assessed halitosis?
Study Design:
Researchers will compare three intervention groups:
Group I: Tongue cleaning. Group II: Chlorhexidine mouthwash. Group III: Coconut oil mouthwash.
After one week, Groups II and III will add tongue cleaning, and in the third week, Groups I and III will use chlorhexidine mouthwash to ensure equitable benefits.
Participants will:
Follow their assigned oral hygiene regimen daily for 2 weeks. Receive the halitosis assessments at baseline, 1 week, and 2 weeks post-intervention, including organoleptic testing and volatile sulfur compounds level measurements using the OralChroma device.
Complete self-reported assessments of halitosis using a visual analog scale (VAS).
93 studies on the registry are indexed under Halitosis; 17 are open to participants now.
This study's enrollment of 42 is close to the median of 45 across 79 interventional studies indexed under Halitosis.
Browse Halitosis studies →Hue University of Medicine and Pharmacy is the lead sponsor of 13 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Diagnosis of Halitosis:
Hydrogen sulfide (H2S) > 1.5 ng/10 ml, OR Methyl mercaptan (CH3SH) > 0.5 ng/10 ml.
Exclusion Criteria:
Dental Conditions:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Other: Mouthrinse with Chlorhexidine 0.12%
Other: Mouthrinse with Coconut oil pulling
Using mouth rinse with coconut oil for two weeks to treat halitosis
Using mouthrinse with 0.12% chlorhexidine for two weeks to treat halitosis
Reduction in Volatile Sulfur Compounds (VSCs) Levels
Measurement of VSC levels (hydrogen sulfide \[H2S\] and methyl mercaptan \[CH3SH\]) in participants' breath using the OralChroma device. Lower VSC levels indicate improved halitosis control.
Time frame: Baseline, 1 week post-intervention, and 2 weeks post-intervention.
Improvement in Organoleptic Test (OT) Scores
Clinical assessment of halitosis severity using the Organoleptic Test, where a trained examiner scores breath odor on a scale of 0 (no odor) to 5 (extremely strong odor). A reduction in OT scores indicates improvement in halitosis.
Time frame: Baseline, 1 week post-intervention, and 2 weeks post-intervention.
Improvement in Self-Reported Halitosis Severity
Participants' self-assessment of halitosis severity using a visual analog scale (VAS) ranging from 0 (no bad breath) to 100 (very severe bad breath). Lower scores indicate improved self-perceived halitosis.
Time frame: Baseline, 1 week post-intervention, and 2 weeks post-intervention.
Ran from Mar 2024 to primary completion in May 2024, 2 months.
Of 35 non-industry interventional studies with no phase under Halitosis, half reached primary completion within 10 months of starting (the median), counting those still running; a quarter within 3 and three quarters within 18. This study's 2 months is below that.
Counting every sponsor, half of 43 studies reached it within 10 months; a quarter within 3 and three quarters within 18.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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Hue University of Medicine and Pharmacy