An interventional study of Probiotic (L. brevis CD2 lozenges) and Zinc chlorhexidine mouth wash in Halitoses, sponsored by Sara M Almshhadany. Recruiting at 1 site in Iraq. Open to participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-09.
Sponsored by Sara M Almshhadany · Not applicable, Interventional, and Supportive care
This study aims to determine the effect of probiotics and Zn/CHx mouthwashes on plaque accumulation and halitosis in fixed orthodontic patients.
Do probiotics and Zn/CHx mouthwashes have an effect on plaque accumulation and halitosis in fixed orthodontic patients?
93 studies on the registry are indexed under Halitosis; 17 are open to participants now.
This study's planned enrollment of 60 is above the median of 45 across 79 interventional studies indexed under Halitosis.
Browse Halitosis studies →This is the only study on the registry with Sara M Almshhadany as lead sponsor.
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Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
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Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
halitosis
Other: Probiotic (L. brevis CD2 lozenges) · Behavioral: Zinc chlorhexidine mouth wash
1\. Plaque accumulation
Other: Probiotic (L. brevis CD2 lozenges) · Behavioral: Zinc chlorhexidine mouth wash
Probiotic :composed of powerful strain of s.salivarius that preserve innate immune system of the main entry point of the body by taken on a regular basis and establish colonization of the throat and mouth which provide clinical care and support of nose, ear, mouth and throat health and provide fresh breath.
Zinc chlorhexidine mouth wash (Zn/CHX) composed of CHX concentrated 0.025% with Zinc acetate 0.3 %, the low concentration of CHX to maintain optimal efficacy with lower incidence of side effects. Zn /CHX was chosen as the active control due to the fact the mixture of Zn salts with low concentration of CHX have shown superior and sustained intra-oral efficacy in managing intra oral halitosis in randomized clinical tria
Plaque accumulation
plaque build up on bracket surfaces was evaluated by using modified bonded bracket index ( mbb index), Each tooth was divided into four areas (incisal, distal, mesial, gingival). Plaque accumulation was classified into the following assessment grades: grade 0-no plaque, grade 1-plaque covered ≤ 1/3 of the tooth surface, grade 2-plaque covered ≤ 2/3 of the tooth surface, grade 3-plaque covered \> 2/3 of the tooth surface. Plaque index (%)= Total of plaque values/ Number of surfaces/ Highest graduation score × 100.
Time frame: 4 month
Halitosis
subjective assessment of halitosis determined by using organoleptic score (OLS) 0 No perceivable odor 1. Weakly perceivable odor 2. Perceivable odor 3. Moderate odor 4. Strong odor 5. Extremely strong odor
Time frame: 4 month
Plan to share: Yes — all data
Supporting information: Statistical analysis plan
Time frame: 2027-2028
Access criteria: researcher
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