An observational study in Sepsis, Septic Shock and Septic Syndrome, sponsored by Sisli Hamidiye Etfal Training and Research Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-01-21.
Sponsored by Sisli Hamidiye Etfal Training and Research Hospital · Observational
This prospective study aims to determine the relationship between the EASIX score and mortality and prognosis in sepsis.
Sepsis is a life-threatening condition characterized by a dysregulated host response to infection, leading to organ dysfunction. Despite advancements in medicine, sepsis remains a significant cause of death worldwide. An international study showed that 48.9 million sepsis cases were diagnosed in 195 countries between 1990 and 2017, resulting in 11 million deaths. Recent studies have demonstrated that early diagnosis and treatment reduce sepsis mortality. Therefore, research has focused on identifying biomarkers that aid in early diagnosis and prognosis.
The Endothelial Activation and Stress Index (EASIX) was first defined by Luft et al. as a biomarker reflecting endothelial damage. Calculated using readily available laboratory parameters-serum lactate dehydrogenase (LDH) level (U/L) x creatinine level (mg/dL) / platelet count (10⁹/L)-it has been commonly used to predict mortality and prognosis in hematological malignancies. Recently, its application in predicting sepsis mortality and prognosis has gained attention, although only limited retrospective studies have been published.
1,899 studies on the registry are indexed under Sepsis; 462 are open to participants now.
This study's enrollment of 150 is close to the median of 160 across 931 observational studies indexed under Sepsis.
Browse Sepsis studies →Sisli Hamidiye Etfal Training and Research Hospital is the lead sponsor of 110 studies on the registry; 14 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult patients (≥18 years old) diagnosed with sepsis were included.
Patients diagnosed with sepsis during intensive care admission or admitted to intensive care with a diagnosis of sepsis
Exclusion Criteria:
Patients under the age of 18
Adult patients (≥18 years old) diagnosed with sepsis
mortality
The primary finding of the study was 28-day mortality after sepsis diagnosis
Time frame: 28 days
Septic shock
Septic shock was defined according to the SEPSIS-3 guidelines as the need for vasopressors or inotropes in patients diagnosed with sepsis.
Time frame: 28 days
Acute kidney injury
Acute kidney injury was defined according to KDIGO guidelines as a ≥0.3 mg/dL increase in serum creatinine over 48 hours, a ≥1.5-fold increase in serum creatinine over 7 days, or urine output \<0.5 mL/kg/hour for 6 consecutive hours.
Time frame: 28 days
This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Sisli Hamidiye Etfal Training and Research Hospital