A Phase 4 interventional study of Carotenoids and Placebo in Healthy Volunteer, Skin Condition and Ageing Signs, sponsored by RDC Clinical Pty Ltd. Completed at 1 site in Australia. Open to female participants aged 40 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-03-06.
Sponsored by RDC Clinical Pty Ltd · Phase 4, Interventional, and Treatment
The goal of this study is to investigate the efficacy of carotenoids administered orally on skin health, skin condition and visible signs of ageing in healthy females aged 40-55 years old.
Researchers will compare the study product against placebo.
538 studies on the registry are indexed under Skin Diseases; 92 are open to participants now.
This study's enrollment of 80 is above the median of 60 across 372 interventional studies indexed under Skin Diseases.
Browse Skin Diseases studies →RDC Clinical Pty Ltd is the lead sponsor of 34 studies on the registry; 8 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Received cosmetic surgery or procedures, including Botox and other injectables, microdermabrasion and laser treatments on their face within last 3 months prior to enrolment and agree not to have these treatments during the study period.
CaroRite capsule containing carotenoids with sunflower oil. 1 capsule to be taken each day for 12 weeks.
Dietary Supplement: Carotenoids
Placebo capsule containing sunflower oil. 1 capsule to be taken each day for 12 weeks.
Other: Placebo
CaroRite capsule containing carotenoids with sunflower oil. 1 capsule to be taken each day for 12 weeks.
Also known as: CaroRite
Placebo capsule containing sunflower oil. 1 capsule to be taken each day for 12 weeks.
Change from baseline to the end of the study period in Visible signs of ageing
Assessed using the A-One Smart Pro, this device provides and automatic skin analysis by scanner and multi-sensor. It uses a high-resolution camera to take photographs of the skin in normal, UV and polarized light. Wrinkles will be measured as thin and thick and rated on a scale of 1-10 in each area of the face: forehead, eyes, mouth and nose. An attached probe measures skin temperature and moisture. Visible signs of ageing measured include: * Skin elasticity * Hydration * Wrinkle depth and type * Sebum * pigmentation * Skin pH and temperature
Time frame: Baseline to week 12
Change from baseline to the end of the study period in Transepidermal water loss (TEWL)
Change from baseline to the end of the study period in Transepidermal water loss (TEWL). Analysed using a DermaLab Combo system with a probe for measurement.
Time frame: Baseline to week 12
Change from baseline to the end of the study period in Skin collagen thickness
Change from baseline to the end of the study period in Skin collagen thickness. Analysed using the DermaLab Combo system with a probe to measure.
Time frame: Baseline to week 12
Change from baseline to the end of the study period in Skin carotenoid analysis
Change from baseline to the end of the study period in Skin carotenoid analysis. This will be measured using a non-invasive device that measures skin carotenoid levels using reflection spectroscopy.
Time frame: Baseline to week 12
Change from baseline to the end of the study period in Safety and adverse events
Change from baseline to the end of the study period in Safety and adverse events. At each point of contact the participant will be asked about adverse events they may have experienced.
Time frame: Baseline to week 12
Change from baseline to the end of the study period in Participant self-assessment of product effectiveness
Change from baseline to the end of the study period in Participant self-assessment of product effectiveness. This Consists of questions related to overall satisfaction with the product and specific facial and skin properties
Time frame: Baseline to week 12
Change from baseline to the end of the study period in Self-administered carotenoid intake questionnaire
Change from baseline to the end of the study period in Self-administered carotenoid intake questionnaire. The questionnaire consists of 17 questions related to overall satisfaction with the product and specific facial and skin properties.
Time frame: Baseline to week 12
Change from baseline to the end of the study period in 24-hour diet recall
Change from baseline to the end of the study period in 24-hour diet recall
Time frame: Baseline to week 12
Skin carotenoid analysis (Veggie Metre)
Change from baseline to the end of the study period in Skin carotenoid analysis (Veggie Metre). Analysed using the Veggie Meter analyser. The Veggie Meter® is a non-invasive device that measures skin carotenoid levels using reflection spectroscopy. It shines a specific wavelength of light onto the skin (typically from an LED) and analyses the light that is absorbed and reflected. Carotenoids absorb certain wavelengths of light, and the device quantifies this absorption to determine carotenoid concentration in the skin.
Time frame: Baseline to week 12
Plan to share: Undecided
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This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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RDC Clinical Pty Ltd