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Enrolling by invitationNCT06875323Updated Jul 29, 2026

FostrSpace-CASA R61/R33

An interventional study of ECHO-FostrSpace and Informational Session in Substance Use, sponsored by University of California, San Francisco. Enrolling by invitation at 1 site in United States. Open to participants aged 13 Years to 20 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-29.

Sponsored by University of California, San Francisco · Not applicable, Interventional, and Prevention

From the registry’s dates

  • Registered 9 months after the study started (first participant enrolled Mar 2024, registered Dec 2024).
Phase
Not applicable
Study type
Interventional
Enrollment
400
Allocation
Randomized
Ages
13 Years to 20 Years
Sex
All
01

Study summary

The purpose of this study is to understand how an online digital health application (app) called FostrSpace can reduce substance use among youth (ages 13-20 years old) in foster care.

Read the detailed description

The goal of this clinical trial is to identify gaps in substance use prevention across existing CASA trainings and the FostrSpace app for foster youth and test how substance use trainings for CASA volunteers could help facilitate FostrSace app referrals to reduce and prevent substance use among CASA youth.

02

Conditions studied

  • Substance Use

Keywords

  • Foster youth
  • Substance use
  • mHealth
03

In context

Substance-Related Disorders

2,124 studies on the registry are indexed under Substance-Related Disorders; 393 are open to participants now.

This study's planned enrollment of 400 is above the median of 108 across 1,727 interventional studies indexed under Substance-Related Disorders.

Browse Substance-Related Disorders studies →

Lead sponsor

University of California, San Francisco is the lead sponsor of 2,132 studies on the registry; 375 are open to participants now.

Of its 262 completed or terminated interventional studies of FDA-regulated products, 196 (75%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
13 Years to 20 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Adolescents and young adults will be eligible if they are age 13-20, are proficient in English, have an assigned CASA worker, and have a device with web access.
  • CASAs (ages 18 and over) will be eligible if they are assigned to a youth between the ages of 13- 20.

Exclusion criteria

Exclusion Criteria:

  • Youth: Exclusion criteria include being non-English speaking, being within 3 months of ending with CASA services, cognitive impairment that precludes ability to provide informed consent.
  • CASA: Exclusion criteria include being non-English speaking and working with a youth who is within 3 months of ending with CASA services.
05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
400 participants (estimated)

Study arms

  • Experimental
    InfoECHO

    CASA volunteers will attend a six 90-minute/biweekly co-occurring SU and trauma ECHO trainings.

    Other: ECHO-FostrSpace

  • Other
    InfoOnly

    CASA volunteers will attend a one-time 30-60 minute co-occurring SU and trauma ECHO training.

    Other: Informational Session

Interventions

  • OtherECHO-FostrSpace

    Six ECHO-FostrSpace session training for CASA volunteers.

  • OtherInformational Session

    One ECHO-FostrSpace session training for CASA volunteers.

06

What researchers measure

Primary outcomes

  1. Rate of Drug Use

    The Texas Christian University (TCU) drug screen with opioid supplement is used to gather detailed information about drug and opioid use.

    Time frame: baseline

  2. Rate of Cigarette Use

    The Cigarette smoking and vaping/e-cigarette use is used to gather detailed information about nicotine and/or cannabis use.

    Time frame: baseline

Secondary outcomes

  1. The Alcohol and Marijuana Expectancy Questionnaire

    The Alcohol and Marijuana Expectancy questionnaire is used to measure positive and negative expectancies about affective, cognitive and behavioral effects of alcohol and cannabis use. Items are rated from 1-5 scale and higher scores indicate negative alcohol and marijuana expectancies.

    Time frame: baseline

  2. The Brief Young Adult Alcohol Consequences Questionnaire

    The Brief Young Adult Alcohol Consequences Questionnaire is used to assess the severity of alcohol consumption. Higher scores indicate greater severity of consequences associated with alcohol consumption.

    Time frame: baseline

  3. The Brief Marijuana Consequences Questionnaire

    The Brief Marijuana Consequences Questionnaire is used to assess the severity of marijuana consumption. Higher scores indicate greater severity of consequences associated with marijuana consumption.

    Time frame: baseline

  4. The Brief Symptom Inventory

    Brief Symptom Inventory is used to measure depression, anxiety and somatization symptoms to assess for psychiatry distress. Index ranging from 0 to 72 with cut-score of 11 as indication of psychiatric distress.

    Time frame: baseline

Other outcomes

  1. CASA Background Characteristics

    Demographics questionnaire used to gather standard demographics (e.g., age, gender, race) and information such as state agency involvement (e.g., age at first contact with child welfare, number of out-of-home placements, length of time worked with a CASA), immigration status.

    Time frame: baseline

  2. Arrest and Treatment

    The Arrest and treatment history (ATH) questionnaire is used to gather information about past juvenile legal system contact (arrest, probation, detention), mental health (MH) and substance use (SU) diagnoses, and past services utilization for SU and/or MH (inpatient, residential, outpatient).

    Time frame: baseline

  3. Youth Background Characteristics

    Youth's living situation questionnaire will be used to gather information related to the youth's living situation over the past 4 months (e.g., in the community, residential treatment, or other living situation).

    Time frame: baseline

  4. Social Determinants of Health

    We will administer an 18-item yes/no questionnaire to gather information on what youth perceive as most relevant and important social determinants of health items for foster youth (i.e., employment, food, family, healthcare, housing, legal, education, safety at school/work, transportation, "other" needs).

    Time frame: baseline

  5. Therapeutic Alliance

    The Working Alliance Inventory (WAI) is used to assess youth's perception of therapeutic alliance (with provider) over time. Scores range from 12-84 with higher scores indicating greater perceived therapeutic alliance.

    Time frame: baseline

  6. Youth/CASA Relationship

    Frequency and quality of CASA-youth conversations about substance use: For frequency, we will adapt an item from a validated measure of parent-child communication about sex used in previous studies45 "How many times have you and your CASA talked about \[alcohol, marijuana, cocaine\]" (each drug asked separately). For quality, we will use one-item from the scale that assesses perceived helpfulness 'How helpful do you think your discussions about alcohol and/or drugs were?' and one-item that assesses perceived comfort 'How comfortable are you with these discussions about alcohol and/or drugs with your \[CASA youth\] or \[CASA\].

    Time frame: baseline

  7. Trauma

    6: deidentified assessment of Adverse Childhood Experiences (10 items) and Related Life Events (7 items).

    Time frame: baseline

  8. Ethnic Identity

    The Scale of Ethnic Experience is used to measures youth ethnicity-related cognitive constructs (e.g., perceptions of their own ethnic group, ethnic group belonging) in four domains: Ethnic Identity(12-items; α =.87); Perceived Discrimination (9-items; α = .91); Mainstream Comfort (6-items; α=.87); and Social Affiliation (5-items; α =.83). Items rated on a scale from 1 (strongly disagree) to 5(strongly agree).

    Time frame: baseline

  9. Stigma

    The Social Distance Scale (SDS) is used to assess a person's willingness to interact with others with mental illness (SDS) or substance users (SDS-SU).

    Time frame: baseline

  10. Peer Substance Use

    The Monitoring the Future is used to assess how many close friends are using alcohol, cannabis and other drugs occasionally and regularly.

    Time frame: baseline

  11. Background Characteristics

    A Demographics Questionnaire is used to gather standard demographics (e.g., age, gender, race) and information about employment, number of years as CASA volunteer, length of time known current foster youth, immigration status, country of origin.

    Time frame: baseline

  12. Substance use prevention related knowledge, beliefs, attitudes and self efficacy

    Beliefs about youth SU will be measured using an adapted 9 item perceived risk of SU measure used in studies of similar risk perceptions (among parents) associated with youth substance use. Items such as "If your youth were to use alcohol more than once a week, what do you think are the chances of them becoming (for example) addicted to alcohol, developing cancer (or lung cancer for drugs that can be smoked), experiencing brain injury etc.

    Time frame: baseline

  13. Compassion Satisfaction and Fatigue

    The Professional Quality of Life will be used to gather information about compassion satisfaction and compassion fatigue.

    Time frame: 30 days post baseline, 60 days post baseline

  14. FostrSpace App Utilization

    Number of app log-in's, days of use, time spent using app, number and type of features used e.g.,chat use (peer/FAB), chat use (navigator), number of clicks on SU prevention content (e.g., SU resources requested, peer "adulting 101" SU prevention video watched), requested navigator support (yes/no), requested navigator support about SU (yes/no), requested teletherapy \[primary presenting need, type of intervention, e.g., primary SU or MH or co-occurring, modality of intervention (individual, group, family), number and frequency of sessions received\].

    Time frame: baseline, 30 days post baseline, 60 days post baseline

  15. Psychiatric Symptoms

    The Emotional Wellness Questionnaire is used to assess psychiatric symptoms (e.g., depression, anxiety, mania) and substance use.

    Time frame: baseline

  16. FostrSpace Usability

    The System Usability Scale (SUS) is used to gather information about the overall usability of web applications. 10- item measure widely used for web applications and proven superior to other measures. SUS yields a single number representing a composite measures of the overall usability of the system being studied60,61. Scores will be compared to established norms for levels of usability. Our goal is a score of 80 (top 10% of scores), which reflects excellent usability, and is associated with recommending the product to a friend.

    Time frame: 30 days post baseline, 60 days post baseline

07

Study locations

1 site
  • UCSF Zuckerberg San Francisco General Hospital
    San Francisco, California 94131, United States
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 29, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06875323
Lead sponsor
University of California, San Francisco
Collaborators
National Institute on Drug Abuse (NIDA)
Responsible party
Sponsor
First posted
Mar 13, 2025
Start date
Mar 1, 2024
Primary completion
Mar 1, 2029 (estimated)
Completion
Mar 1, 2029 (estimated)
Last update
Jul 29, 2026

Study contacts

Marina Tolou-Shams, PhD
principal investigator · University of California, San Francisco

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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