A Phase 1/2 interventional study of TIMP2 level in Acute Kidney Injury, Extracorporeal Circulation; Complications and Surgery, sponsored by Wuhan University. Completed at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-03-12.
Sponsored by Wuhan University · Phase 1/2, Interventional, and Other
Acute kidney injury (AKI) is one of the most frequent major complications in patients undergoing cardiac surgery. CSA-AKI is independently related to increased perioperative mortality, increased hospital and ICU length of stay as well as heath care expenditure. Identification of relevant biomarkers may lead to early diagnosis and improve patient outcomes and health care costs. The pathophysiology of CSA-AKI is complex and ischemia-reperfusion injury is one of the important factors. Recently, it has been shown that Tissue Inhibitor of Metalloproteinases 2 (TIMP2) is associated with ischemia-reperfusion injury. In this study, relationship between TIMP2 with the risk of CSA-AKI was analyzed and the predictive value of elevated level of TIMP2 for early prediction of CSA-AKI was further evaluated.
1,595 studies on the registry are indexed under Acute Kidney Injury; 371 are open to participants now.
This study's enrollment of 100 is close to the median of 100 across 763 interventional studies indexed under Acute Kidney Injury.
Browse Acute Kidney Injury studies →Wuhan University is the lead sponsor of 45 studies on the registry; 14 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Other: TIMP2 level
Drug: TIMP2 level
Other: TIMP2 level
Drug: TIMP2 level
Other: TIMP2 level
Drug: TIMP2 level
different TIMP2 level after on-pump cardiac surgery
the development of CSA-AKI
the development of CSA-AKI
Time frame: 1 Week
AKI severity
AKI stage 1，stage 2，stage 3
Time frame: 1 Week
need for RRT
Reflect kidney function
Time frame: 1 Week
duration of AKI (≥7 days)
Reflect kidney function
Time frame: 1 Week
length of ICU stay
Reflect patient prognosis
Time frame: up to 28 days
post-operative hospital stay
Reflect patient prognosis
Time frame: up to 28 days
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Wuhan University