An interventional study of Probiotic Agent and Non-Surgical Intervention in Periodontitis Stage III and Probiotic, sponsored by AYŞENUR ŞAHİN. Completed at 1 site in Turkey. Open to participants aged 18 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-12.
Sponsored by AYŞENUR ŞAHİN · Not applicable, Interventional, and Supportive care
Aims: The use of oral probiotics as an adjunct to the treatment of periodontal diseases is known to be beneficial in antagonizing pathogenic microflora and regulating the host immune response. The aim of this clinical study was to evaluate the clinical, microbiologic and biochemical effect of Streptococcus salivarius (S. salivarius) K12 probiotic tablet as an adjunct to scaling and root planing (SRP) treatment in stage 3 periodontitis patients.
Methods: The study included 30 systemically healthy stage 3 periodontitis patients. After non-surgical periodontal treatment, participants were randomly assigned to the test (SRP+Probiotic, n=15) or control (SRP, n=15) group. Patients in the test group used probiotic tablets once daily for 30 days. Clinical (Plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL)), microbiological (Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Prevotella intermedia, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum) and biochemical (IL-6, IL-8, IL-10) measurements were performed at baseline (before SRP), 30. and 90th days. Data were analyzed statistically.
Keywords: Microbiology, Periodontitis, Probiotics, Cytokines
1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.
This study's enrollment of 30 is below the median of 45 across 1,191 interventional studies indexed under Periodontitis.
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Exclusion Criteria:
Other: Probiotic Agent · Other: Non-Surgical Intervention
Other: Non-Surgical Intervention
Patients in the test group were instructed to take one tablet immediately after tooth brushing (before bedtime) once daily for 30 consecutive days. Probiotic was administered in tablets containing 1x109 cfu/g S. salivarius K12.
Patients in the control group received non-surgical periodontal treatment only.
Reduction in Porphyromonas gingivalis at 3 months
Time frame: From enrollment to the end of treatment at 12 weeks
Plan to share: No
This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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