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RecruitingNCT06857838Updated Mar 4, 2025

Myocardialbridge Bypass Graft Surgery Efficacy Verification

An interventional study of MBBG and MB CABG in Myocardial Bridge of Coronary Artery, Myocardial Bridge and Myocardial Bridging, sponsored by Xi'an International Medical Center Hospital. Recruiting at 1 site in China. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2025-03-04.

Sponsored by Xi'an International Medical Center Hospital · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 5 years 1 month after the study started (first participant enrolled Jan 2020, registered Feb 2025).
  • Started Jan 2020; still recruiting 6 years 10 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
500
Allocation
Non-randomized
Ages
18 Years to 80 Years
Sex
All
01

Study summary

Myocardial Bridge Bypass Graft surgery is introduced to relieve the unmedical symptoms of patients with long-segment or deep myocardial bridge, clinical outcomes will be collected to verify the effectiveness of the surgery.

02

Conditions studied

  • Myocardial Bridge of Coronary Artery
  • Myocardial Bridge
  • Myocardial Bridging
  • Myocardial Infarction
  • Myocardial Ischemia
  • Pectoris, Stable Angina
  • Sudden Cardiac Death
  • Bypass Graft Stenosis
  • Bypass Graft Occlusion
  • Bypass Graft Thrombosis
03

In context

Myocardial Infarction

2,270 studies on the registry are indexed under Myocardial Infarction; 371 are open to participants now.

This study's planned enrollment of 500 is above the median of 150 across 1,314 interventional studies indexed under Myocardial Infarction.

Browse Myocardial Infarction studies →

Lead sponsor

Xi'an International Medical Center Hospital is the lead sponsor of 5 studies on the registry; 3 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients with myocardialbridge requiring drug therapy or surgical intervention.

Exclusion criteria

Exclusion Criteria:

  • patients with myocardialbridge not requiring drug therapy or surgical intervention, or unwilling to be enrolled for any reason
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Parallel assignment
Masking
Double (Investigator, Outcomes assessor)
Enrollment
500 participants (estimated)

Study arms

  • Experimental
    MyocardialBridge Bypass Graft

    The patients with deep(depth\>2mm) and long-segement(length\>25mm) of myocardialbridge receiving myocardialbridge bypass graft surgery(MBBG),fulfilling the following criteria: 1.presenting with pectoris angina that cannot be effectively relieved by maximum guideline-directed drug therapy; 2. No atherosclerotic plaque or merely mild atherosclerotic stenosis is detected at the proximal or entry of the myocardialbridge confirmed by coronory artery angiography.

    Procedure: MBBG

  • Active comparator
    Myocardialbridge CABG

    The patients with deep(depth\>2mm) and long-segement(length\>25mm) of myocardialbridge will be allocated to receive myocardialbridge bypass graft surgery(MBBG),when fulfilling the following criteria: 1.presenting with pectoris angina that cannot be effectively relieved by maximum guideline-directed drug therapy; 2. The moderate-to-severe atherosclertotic stenosis is detected at the proximal or entry of the myocardialbridge confirmed by coronory artery angiography.

    Procedure: MB CABG

  • Active comparator
    Myocardioalbridge Unroof

    The patients with superficial type(depth\<2mm) and short-segement(length\<25mm) of myocardial bridge will be allocated to receive "unroof" surgery,when fulfilling the following criteria: 1.presenting with pectoris angina that cannot be effectively relieved by maximum guideline-directed drug therapy; 2. No atherosclerotic plaque or merely mild atherosclerotic stenosis is detected at the proximal or entry end of the myocardialbridge confirmed by coronory artery angiography.

    Procedure: MB unroof

Interventions

  • ProcedureMBBG

    The patients with deep(depth\>2mm) and long-segement(length\>25mm) of myocardialbridge receiving myocardialbridge bypass graft surgery(MBBG),fulfilling the following criteria: 1.presenting with pectoris angina that cannot be effectively relieved by maximum guideline-directed drug therapy; 2. No atherosclerotic plaque or merely mild atherosclerotic stenosis is detected at the proximal or entry of the myocardialbridge confirmed by coronory artery angiography.

  • ProcedureMB CABG

    The patients with deep(depth\>2mm) and long-segement(length\>25mm) of myocardialbridge receiving myocardialbridge bypass graft surgery(MBBG),fulfilling the following criteria: 1.presenting with pectoris angina that cannot be effectively relieved by maximum guideline-directed drug therapy; 2. The moderate-to-severe atherosclerotic stenosis is detected at the proximal or entry of the myocardialbridge confirmed by coronory artery angiography.

  • ProcedureMB unroof

    The patients with superficial type(depth\<2mm) and short-segement(length\<25mm) of myocardial bridge will be allocated to receive myocardialbridge "unroof" surgery,when fulfilling the following criteria: 1.presenting with pectoris angina that cannot be effectively relieved by maximum guideline-directed drug therapy; 2. The MB was superficial and short confirmed by coronory artery CT angiography.

06

What researchers measure

Primary outcomes

  1. All-Cause Mortality

    Time frame: Up to 240 months

  2. Rate of counduit patency

    Time frame: Up to 180 months

07

Study locations

1 of 1 sites recruiting
  • Xi'an International Medical Center Hospital Affiliated TO Northwest University
    Xi'an, Shaanxi 710100, China
    Recruiting
08

References and documents

Publications

  • Zhang JZ, Zhu GY, Zhang Y, Bai LJ, Wang Z. Myocardial Bridge Bypass Graft: A Novel Surgical Procedure for Extensive Myocardial Bridges. Ann Thorac Surg. 2021 Aug;112(2):e115-e117. doi: 10.1016/j.athoracsur.2020.11.055. Epub 2021 Jan 20. PubMed 33482166 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 4, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06857838
Lead sponsor
Xi'an International Medical Center Hospital
Responsible party
Wang zhen (Principal Investigator, Xi'an International Medical Center Hospital) — Principal investigator
First posted
Mar 4, 2025
Start date
Jan 1, 2020
Primary completion
Dec 31, 2030 (estimated)
Completion
Dec 31, 2040 (estimated)
Last update
Mar 4, 2025

Study contacts

Zhen Wang, Doctorate
Contact
wang.zhen@000516.cn
+86-029-68302464
Jinzhou Zhang, Doctorate
Contact
zhang.jinzhou@000516.cn
+86-029-68302464
Zhen Wang, Doctorate
principal investigator · Xi'an International Medical Center Hospital Affiliated To Northwest University
Jinzhou Zhang, Doctorate
study director · Xi'an International Medical Center Hospital Affiliated To Northwest University
Jinzhou Zhang, Doctorate
study chair · Xi'an International Medical Center Hospital Affiliated To Northwest University

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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