An observational study in Benign Paroxysmal Positional Vertigo (BPPV), sponsored by Aalborg University Hospital. Enrolling by invitation at 1 site in Denmark. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-19.
Sponsored by Aalborg University Hospital · Observational
This study aims to investigate whether the diagnosis of benign paroxysmal positional vertigo (BPPV) is equally good with two different mechanical rotation chairs (MRCs) (TRV rotary chair and the Rotundum rotary chair). In the study, two different diagnostic criteria will be used (the international Bárány criteria and the American Academy of Otolaryngology-Head and Neck surgery (AAO-HNS) criteria) with both MRCs.
Patients with BPPV experience brief attacks of positional vertigo. Typically, this vertigo is provoked by changes in head position relative to gravity, e.g. laying down or turning to the side from the supine position.
Previous studies on the use of MRCs have shown that MRCs offer very precise and accurate BPPV diagnostics. With MRCs it is possible to determine 1) laterality (left/right), 2) specific location (specific semicircular canal), and 3) BPPV subtype (canalolithiasis/cupulolithiasis). Treatment-wise, these MRCs have also shown to be very efficient with treatment success rates being above ninety percent. The two MRCs used in this study do not offer the exact same features (e.g. design, portability, fixed positions, and the possibility of adding kinetic energy). To the knowledge of the authors, no studies exist on direct comparison of separate MRCs. The Rotundum rotary chair, which is also the newest of the two MRCs included, has so far not been included in many studies. However, the hypothesis of the current study is that the Rotundum rotary chair and the TRV rotation chair are equally good in terms of BPPV diagnostics.
The primary aim is to investigate whether diagnostics of benign paroxysmal positional vertigo (BPPV) is equally good with two different MRCs, using both the international Bárány Society criteria and the American AAO-HNS criteria with both MRCs. Whether or not these two MRCs may be considered equally good will be evaluated based on the number of identified BPPV cases with each MRC as well as laterality (right/left), semicircular canal location (anterior/posterior/lateral) and subtype of BPPV (canalithiasis/cupulolithiasis). The participants in this study are patients with a typical BPPV history that have been referred to a University Hospital based tertiary dizziness outpatient clinic.
The following mechanical rotation chairs will be used:
With MRC testing, advanced videonystagmography (VNG) glasses are used to visualize, monitor, and register eye movements. With the TRV chair, VF405® (Interacoustics©, Middelfart, Denmark) will be used with the software Micromedical VisualEyes™ (version 3.1.0.203, Interacoustics©, Middelfart, Denmark). With the Rotundum chair, the ICS Impulse® (Natus Inc©, Middleton, WA, USA) will be used with the software OTOsuite (4.88®, Natus Inc©, Middleton, WA, USA).
The same diagnostic procedure will be performed with each MRC. This includes the supine position, bilateral supine roll tests (SRTs), bilateral Dix-Hallpike tests, and, if lateral canal BPPV is ambigious, the bow and lean test. Initial MRC will be randomized.
For each participant, the following data will be collected:
Sample size assessment Data will be analyzed using Cohen's Kappa. A dropout rate of 10 percent and a power of 90 percent is expected.
75 studies on the registry are indexed under Benign Paroxysmal Positional Vertigo; 15 are open to participants now.
This study's planned enrollment of 200 is above the median of 104 across 11 observational studies indexed under Benign Paroxysmal Positional Vertigo.
Browse Benign Paroxysmal Positional Vertigo studies →Aalborg University Hospital is the lead sponsor of 198 studies on the registry; 41 are open to participants now.
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Subjects are referred by their general practitioner or from a private ENT on the basis of a typical BPPV case history and/or clinical findings suggesting the presence of BPPV to examination in a rotation chair at the investigational site.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
A group of participants with suspected BPPV who undergo a diagnostic procedure for BPPV in the TRV chair. The diagnosis, laterality, semicircular canal localization, and subtypes in this group are determined according to the diagnostic criteria published by the Bárány Society.
Device: TRV® (Interacoustics©, Middelfart, Denmark), mechanical rotational chair
A group of participants with suspected BPPV who undergo a diagnostic procedure for BPPV in the Rotundum chair. The diagnosis, laterality, semicircular canal localization, and subtypes in this group are determined according to the diagnostic criteria published by the Bárány Society.
Device: Rotundum® (balcare GmbH©, Küsnacht, Switzerland), mechanical rotational chair.
A group of participants with suspected BPPV who undergo a diagnostic procedure for BPPV in the TRV chair. The diagnosis, laterality, semicircular canal localization, and subtypes in this group are determined according to the diagnostic AAO-HNS criteria.
Device: TRV® (Interacoustics©, Middelfart, Denmark), mechanical rotational chair
A group of participants with suspected BPPV who undergo a diagnostic procedure for BPPV in the Rotundum chair. The diagnosis, laterality, semicircular canal localization, and subtypes in this group are determined according to the diagnostic AAO-HNS criteria.
Device: Rotundum® (balcare GmbH©, Küsnacht, Switzerland), mechanical rotational chair.
Diagnostic positioning maneuvers performed using the TRV® MRC to evaluate the presence, affected semicircular canal, and subtype of Benign Paroxysmal Positional Vertigo.
Diagnostic positioning maneuvers performed using the Rotundum® MRC to evaluate the presence, affected semicircular canal, and subtype of Benign Paroxysmal Positional Vertigo.
Difference in the ability to diagnose BPPV
Statistically significant difference in the ability to induce nystagmus and/or vertigo between the TRV chair and Rotundum chair.
Time frame: 40 minutes
Agreement on the diagnosis of BPPV in individual semicircular canals and subtype of BPPV
Statistically significant difference in the ability to induce nystagmus and/or vertigo between the TRV chair and Rotundum chair for each individual semicircular canal and for subtype of BPPV i.e. canalolithiasis or cupulolithiasis.
Time frame: 40 minutes
Plan to share: No
Start is estimated for Sep 2026; primary completion for Dec 2026, 3 months later.
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