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RecruitingNCT06835842Updated Jul 10, 2025

Effect of Rib Mobilization on Weaning Parameters From Mechanical Ventilator in Patients With Pneumonia

An interventional study of rib mobilization technique and routine chest physiotherapy in Pneumonia, sponsored by Cairo University. Recruiting at 1 site in Egypt. Open to participants aged 40 Years to 50 Years. Per ClinicalTrials.gov, last updated 2025-07-10.

Sponsored by Cairo University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Feb 2026, 7 months ago, but the record still lists the study as recruiting.
  • Started Mar 2025; still recruiting 1 year 6 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Randomized
Ages
40 Years to 50 Years
Sex
All
01

Study summary

this study will be conducted to distinguish between effect of rib mobilization and routine chest physiotherapy on weaning parameters from mechanical ventilator in patients with pneumonia •

HYPOTHESES:

It will be hypothesized that there may be significant effect of rib mobilization on weaning parameters from mechanical ventilator in patients with pneumonia.

RESEARCH QUESTION:

Does rib mobilization have an effect on weaning parameters from mechanical ventilator in patients with pneumonia? measuring weaning parameters: on screen of mechanical ventilator : measuring respiratory rate, Tidal volume (TV), FiO2.

  • Arterial blood gases (ABG) analyzer machine ABG is recorded daily (PH- PaO2 - PaCO2)
  • Length of ICU stay: calculated by (admission date - discharge date
  • Weaning success rate
Read the detailed description

Ventilator-associated pneumonia (VAP) represents a significant sub-set of (HAP) remains the most frequent intensive care unit (ICU)-acquired infection its incidence ranges from 9% to 27% of ventilated patients ,VAP is associated with an increased length of stay, mortality and health care costs, Pneumonia can result in chest wall stiffness, decreased mobility, limiting the range of motion during breathing and decreased lung compliance and impaired respiratory function , Rib mobilization: is an articular , non-invasive, passive technique that can be useful with acutely ill, hospitalized patients emphasizes the placement of a repetitive force to increase the range of motion of the posterior rib articulations and chest wall , lessening somatic dysfunction of the spine, stretches myofascial structures and improve respiratory mechanics So, this study will be conducted to distinguish between effect of rib mobilization and routine chest physiotherapy on weaning parameters among intubated pneumonic patients on mechanical vent.

02

Conditions studied

  • Pneumonia

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03

In context

Pneumonia

2,044 studies on the registry are indexed under Pneumonia; 283 are open to participants now.

This study's planned enrollment of 60 is below the median of 106 across 1,247 interventional studies indexed under Pneumonia.

Browse Pneumonia studies →

Lead sponsor

Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.

Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
40 Years to 50 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  1. Patient's age ranged from 40- 50 years old from both genders.
  2. Diagnosed with pneumonia and need invasive mechanical ventilation support.
  3. Stable oxygen saturation (SpO2 more than 85, (FiO2) 0.6 or less, PEEP less than 10 Cm H2O).
  4. mean arterial pressure > 75 mmHg and urine output > 1 mL/kg/h;
  5. Patients with Glasgow coma scale (GCS) > 8T
  6. Unconscious and semi-conscious patients. -

Exclusion criteria

Exclusion Criteria:

  1. Unstable hemodynamics
  2. Unstable neurological problems e.g. (epileptic seizures -hyperthermia).
  3. Unstable chest wall e.g. (multiple rib or vertebral fractures)
  4. Increase intracranial pressure (>20 mmHg for >5 min).
  5. Undrained pneumothorax, recent pulmonary surgery
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
60 participants (estimated)

Study arms

  • Experimental
    rib mobilization technique and routine chest physiotherapy group

    1.rib mobilization technique and routine chest physio therapy group: the patients will receive rib mobilization technique in addition to their medical treatment and routine chest physiotherapy for at least 30 minutes once daily for ten consecutive days

    Other: rib mobilization technique · Other: routine chest physiotherapy

  • Active comparator
    routine chest physiotherapy group

    routine chest physiotherapy group : the patients in this group will receive routine chest physical therapy for at least 30 minutes once daily for 10 consecutive days

    Other: routine chest physiotherapy

Interventions

  • Otherrib mobilization technique

    rib mobilization technique The patient in experimental group will be relaxed in semi- fowler position while connected to mechanical ventilator, therapist will seat at the patient "side, his fingers pads are placed at the position of the patient's rib angles , pulling upward and the lateral position the position is held while wait for the soft tissues to release this take from 15 seconds .Release of the diaphragm through manual contact with hypothenar region of therapist thumb inferior laterally xiphoid process and rest along Antero lateral costal margin below rib7 during exhalation the therapist thumb give pressure posteriorly repeat this steps for 3 to5 respiratory cycle • routine chest physiotherapy percussion on chest wall its frequency should be 3-7 beats per sec. vibration applying a light pressure with hand on affected segment for about 5 min modified postural drainage R. and L. side. U\&L limb passive ex. for R.10 x3 set .this program for 30 minutes once daily for ten days

  • Otherroutine chest physiotherapy

    routine chest physiotherapy the patient will be laid in half supine position connected to a ventilator applying * percussion on chest wall its frequency should be 3-7 beats per second or 180-420 beats per minute * vibration applying a light pressure with flattened hand on affected segment for about 5 minutes * modified postural drainage (right and left sidling 10 min for each side * upper and lower limb exercise for 4 limbs (3 sets and each set has 10 repetition * this program for 30 minutes once daily * for 10 consecutive days

06

What researchers measure

Primary outcomes

  1. Arterial blood gases

    • Arterial blood gases (ABG): (PH -PaO2 - PaCO2) • PaO2/FiO2 ratio (P/F): One element of predicting successful weaning from mechanical ventilation is PaO2/FiO2 \> 200

    Time frame: at least 10 consecutive days

  2. Respiratory rate (RR)

    It will be measured using a mechanical ventilator.

    Time frame: at least 10 consecutive days

  3. Tidal volume (TV)

    It will be measured using a mechanical ventilator.

    Time frame: at least 10 consecutive days

Secondary outcomes

  1. Length of hospital stay

    ;• Length of stay in intensive care unite can be defined as the number of days that an in-patient will remain in ICU during a single admission event, is calculated by subtracting the admission date (ADATE) from the discharge date (DDATE)

    Time frame: at least 10 consecutive days

07

Study locations

1 of 1 sites recruiting
  • El Galaa Military Hospital
    Cairo, Egypt
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 10, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06835842
Lead sponsor
Cairo University
Responsible party
Hoda Gaber (Principal Investigator, Cairo University) — Principal investigator
First posted
Feb 19, 2025
Start date
Mar 10, 2025
Primary completion
Feb 10, 2026 (estimated)
Completion
May 20, 2026 (estimated)
Last update
Jul 10, 2025

Study contacts

hoda gaber el said, master
Contact
huda.eaid68@gmail.com
01100272020
. Shymaa Mohamed Ali, lecturer
Contact
shymaaali@pt.cu.edu.eg
01144242511
Azza Abd El Aziz Abd El Hady, professor
study chair · Cairo University
Mohammed Abd Hakim El-Nadi, professor
study director · Cairo University

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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