A Phase 2 interventional study of Full thickness myotomy and Progressive thickness myotomy in Achalasia Cardia and Achalasia, sponsored by Cairo University. Recruiting at 2 sites in Egypt. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2026-10-15.
Sponsored by Cairo University · Phase 2, Interventional, and Treatment
Peroral endoscopic esophageal myotomy (POEM) has been established as an effective therapy for Achalasia. It is still not known how deep the myotomy should be and if it should include the circular and longitudinal muscles or not. It is hypothesized that a complete full thickness myotomy could lead to higher rates of gastroesophageal reflux disease (GERD). In this study we compare performing a Full-thickness myotomy with a progressive myotomy (proximal half circular only, distal half full-thickness, and assessment the different outcomes including efficacy and the incidence of postprocedural GERD.
141 studies on the registry are indexed under Esophageal Achalasia; 45 are open to participants now.
This study's planned enrollment of 70 is above the median of 60 across 94 interventional studies indexed under Esophageal Achalasia.
Browse Esophageal Achalasia studies →Cairo University is the lead sponsor of 4,907 studies on the registry; 1,445 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Procedure will include a full thickness myotomy including both the circular and longitudinal muscle layers throughout the whole length of the myotomy
Procedure: Full thickness myotomy
Procedure will include a progressive thickness myotomy where the proximal half of the myotomy will be selective cutting only the circular muscles, while the distal half will include both circular and longitudinal muscles.
Procedure: Progressive thickness myotomy
Full thickness myotomy
Progressive thickness myotomy
Presence of Esophagitis
Any degree of esophagitis detected endoscopically
Time frame: 6 months after the POEM procedure
Clinical improvement
ECKHART score
Time frame: 6 months after the POEM procedure
Ph manometry
Demeester score
Time frame: 6 months after the POEM procedure
Duration of myotomy
Duration of myotomy
Time frame: During the procedure
Adverse events
Any adverse events
Time frame: up to 6 months after the POEM procedure
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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