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CompletedNCT06835335DOPED-SCDUpdated Jan 23, 2026

Opioid Prescribing in the Emergency Department for Sickle Cell Disease

An observational study in Discrimination, Racial, Pain Management and Emergency Medicine, sponsored by Centre Hospitalier Universitaire de Nīmes. Completed at 2 sites in 2 countries. Per ClinicalTrials.gov, last updated 2026-01-23.

Sponsored by Centre Hospitalier Universitaire de Nīmes · Observational

Study type
Observational
Model
Other
Time perspective
Prospective
Enrollment
1,063
Sex
All
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Study summary

This study consists of a clinical vignette presented to emergency physicians asking them what they would prescribe to a patient with acute abdominal pain.

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Conditions studied

  • Discrimination, Racial
  • Pain Management
  • Emergency Medicine
  • Sickle Cell Disease
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In context

Racism

47 studies on the registry are indexed under Racism; 8 are open to participants now.

This study's enrollment of 1,063 is above the median of 243 across 12 observational studies indexed under Racism.

Browse Racism studies →

Lead sponsor

Centre Hospitalier Universitaire de Nīmes is the lead sponsor of 595 studies on the registry; 90 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Population will consist in emergency medicine resident and physician, speaking French or English, in European countries.

The population will be recruited with the use of professional networks and social medias

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Being a emergency physician

Exclusion criteria

Exclusion Criteria:

  • Working outside of Europe.
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Study design

Observational model
Other
Time perspective
Prospective
Enrollment
1,063 participants (actual)
Patient registry
No

Groups and cohorts

  • Non-black man

    the case will present a non black man

    Behavioral: opioid prescription

  • Black man

    the case will present a non black man

    Behavioral: opioid prescription

  • non-black woman

    the case will present a non black woman

    Behavioral: opioid prescription

  • black woman

    the case will present a black woman

    Behavioral: opioid prescription

Interventions

  • Behavioralopioid prescription

    The intervention consisted of a randomized questionnaire presenting a clinical case of a patient suffering from severe abdominal pain. The control case was "As an emergency physician in an adult emergency department, you are presented with the following patient: The patient is a 39-year-old non-smoking male/female with a history of Meniere's disease and an allergy to Bactrim. He/she presents with abdominal pain that began abruptly 2 hours ago and has persisted despite taking NEFOPAM 45 minutes ago. This is his first episode. His/her vital signs are blood pressure 140/66, heart rate 91, pulse ox 97%, temperature 36.8°C. He/she rates his/her pain as 8/10 without any analgesic position. On clinical examination he/she presents with localized epigastric tenderness. The rest of the abdomen is soft, painless and depressed. There are hydro-aeriform noises. No diarrhea or vomiting. The rest of the clinical examination showed no abnormalities.". In the intervention case, patient had history of S

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What researchers measure

Primary outcomes

  1. Morphine prescription

    The proportion of patient for which physician would have prescribed morphine

    Time frame: through study completion, an average of 1 year

Secondary outcomes

  1. Analgesic prescription between groups

    To compare analgesic prescription between groups

    Time frame: through study completion, an average of 1 year

  2. factors associated with differences in management between groups

    identify factors associated with differences in management (urgency level, morphine prescription and computed tomography scan ordering)

    Time frame: through study completion, an average of 1 year

  3. Differences according to patient and practitioner gender

    analyze the difference in morphine treatment prescribed according to patient and practitioner gender

    Time frame: through study completion, an average of 1 year

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Study locations

2 sites
  • CHU de Nîmes
    Nîmes, Occitanie 30900, France
  • Manchester University NHS FT
    Manchester, Manchester M139WL, United Kingdom
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References and documents

Publications

  • Coisy F, Simon A, Occelli C, Dupriez F, Ageron FX, N'Diaye L, Feral-Pierssens AL, Yates G, Bobbia X. Does a history of sickle cell disease affect the prescription of morphine? An international, randomised study based on clinical vignettes conducted among emergency physicians. BMJ Open. 2025 Dec 24;15(12):e108836. doi: 10.1136/bmjopen-2025-108836. PubMed 41448706 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 23, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06835335
Responsible party
Sponsor
First posted
Feb 19, 2025
Start date
Feb 17, 2025
Primary completion
Mar 19, 2025
Completion
Mar 19, 2025
Last update
Jan 23, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.

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