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Not yet recruitingNCT06833775Updated Feb 20, 2025

Evaluation of Neoadjuvant Therapy Efficacy and Postoperative Pathological Indicators in Esophageal Cancer Using CT and Multimodal MRI

An observational study in Esophageal Cancer and Neoadjuvant Therapy, sponsored by Henan Cancer Hospital. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-02-20.

Sponsored by Henan Cancer Hospital · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
400
Ages
18 Years and older
Sex
All
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Study summary

This study aims to predict the efficacy of different types of neoadjuvant therapy and related postoperative pathological indicators in patients with esophageal cancer based on imaging parameters from CT and multimodal MRI, as well as clinical indicators collected before and after neoadjuvant treatment.

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Conditions studied

  • Esophageal Cancer
  • Neoadjuvant Therapy
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In context

Esophageal Neoplasms

1,593 studies on the registry are indexed under Esophageal Neoplasms; 461 are open to participants now.

This study's planned enrollment of 400 is above the median of 200 across 341 observational studies indexed under Esophageal Neoplasms.

Browse Esophageal Neoplasms studies →

Lead sponsor

Henan Cancer Hospital is the lead sponsor of 228 studies on the registry; 130 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients were diagnosed with esophageal cancer by pathology at Zhengzhou University Affiliated Cancer Hospital from January 1, 2017 to December 31, 2024. Based on pre-treatment examinations such as endoscopic ultrasound, CT, MRI, and multidisciplinary consultation opinions, these patients underwent radical esophagectomy after receiving different kinds of neoadjuvant therapy.

Inclusion criteria

  1. Consecutive patients with histopathological diagnosis of esophageal cancer.
  2. Patients underwent neoadjuvant therapy before radical surgery for esophageal cancer: neoadjuvant chemotherapy, neoadjuvant chemoradiotherapy, neoadjuvant chemotherapy plus immunotherapy, neoadjuvant chemoradiotherapy plus immunotherapy.
  3. All patients underwent CT and multimodal MRI examinations before and after neoadjuvant therapy.
  4. The preoperative clinical data and postoperative pathological data are complete.

Exclusion criteria

Exclusion Criteria:

  1. Patients with other primary malignant tumors or previous anti-tumor treatment.
  2. CT and MRI images with poor quality.
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
400 participants (estimated)
Patient registry
No

Groups and cohorts

  • the group of patients who achieved pathological complete response (pCR) following neoadjuvant
  • the group of patients who did not achieve pCR following neoadjuvant therapy and surgery for esophage
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What researchers measure

Primary outcomes

  1. CT and multimodal MRI in prediction of neoadjuvant therapy efficacy and postoperative pathological indicators in esophageal cancer

    To evaluate the effectiveness of CT and multimodal MRI in determining the neoadjuvant therapy efficacy and postoperative pathological indicators in esophageal cancer.

    Time frame: March 2025 - January 2030

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Study locations

No study locations are listed for this record.

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References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 20, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06833775
Lead sponsor
Henan Cancer Hospital
Responsible party
Qujinrong (Clinical Professor, Henan Cancer Hospital) — Principal investigator
First posted
Feb 19, 2025
Start date
Mar 2025 (estimated)
Primary completion
Jan 2030 (estimated)
Completion
Dec 2030 (estimated)
Last update
Feb 20, 2025

Study contacts

Jinrong Qu
Contact
qjryq@126.com
(86) 0371-65587595

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.

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