An interventional study of Cue reactivity paradigm in Health Behavior, Wellness, Psychological and Substance Use, sponsored by Brown University. Recruiting at 1 site in United States. Open to participants aged 13 Years to 16 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-29.
Sponsored by Brown University · Not applicable, Interventional, and Screening
The goal of this observational study is to learn more about changes in health, wellness, and substance-use behaviors as teenagers get older. Participants, ages 13 to 16, will be asked to use a smartphone application developed for this research study. Participants will also come to Brown University or meet via video conference to answer questions about specific behaviors, choices, and feelings that may change over time.
Exclusion Criteria:
Teenagers ages 13 to 16 years at the time of recruitment.
Other: Cue reactivity paradigm
Participants will be exposed to cues in a fixed sequence while they answer questions about their emotions and thoughts. The cues will include everyday items (e.g., an ink pen) and substance-related items (e.g., a vape pen).
Maximum subjective craving during cannabis cue exposure (rated on a 0 to 10 scale).
This study utilizes a structured cannabis cue exposure paradigm. During cue exposure, participants rate subjective craving on a scale from 0, "Not at all," to 10, "Extremely." The specific item to assess positive effects is the question, "How strong is your craving to use cannabis right now" sourced from the Morean' Drug Craving Questionnaire-Now. See reference section.
Time frame: Baseline, 1 year, 2 years
Maximum subjective positive effects of cannabis use in daily life (rated on a 0 to 10 scale).
This study utilizes a smartphone application to collect self-reported subjective cannabis effects in the participant's daily life. Following a self-initiated report of cannabis use in daily life, participants rate subjective positive effects of cannabis at that moment (i.e., "right now") on a scale from 0, "Not at all," to 10, "Extremely." The specific item to assess positive effects is the question, "Do you like any of the effects you are feeling right now?" sourced from the Tiffany's Drug Effects Questionnaire. See reference section.
Time frame: Baseline, 1 year, 2 years
Plan to share: Yes — De-identified data that cannot individually identify participants may be shared with researchers internal and external to Brown University upon reasonable request by qualified research collaborators. Data shared with qualified researchers will not contain any protected health information or other personally identifiable information that could be used to identify individual participants.
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