A Phase 4 interventional study of Lidocaine in Saline and Normal saline in Spinal Disease, Anesthesia and Post Operative Pain, sponsored by Dartmouth-Hitchcock Medical Center. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-11-24.
Sponsored by Dartmouth-Hitchcock Medical Center · Phase 4, Interventional, and Treatment
The purpose of this study is to determine the effect of lidocaine infusion on intraoperative neuromonitoring in patients undergoing spine surgery.
The investigators will compare the stimulation threshold for motor evoked potentials (MEPs) for patients undergoing spine surgery with intraoperative neurophysiologic monitoring (IONM) who receive a lidocaine infusion vs. normal saline (NS) infusion. The endpoint for this objective will be the final stimulation threshold for MEPs at the end of the surgery. The stimulation threshold for MEPs is a commonly used metric to determine the effects of anesthetic agents on MEP signals. Secondary objectives will somatosensory evoked potentials (SSEPs) with an endpoint of amplitude and latency of SSEPs throughout the surgery. Other secondary outcomes will include, intraoperative mean arterial pressure (MAP), intraoperative propofol consumptions, and post-operative visual analog scale (VAS) and opioid consumption.
174 studies on the registry are indexed under Spinal Diseases; 39 are open to participants now.
This study's planned enrollment of 44 is below the median of 60 across 106 interventional studies indexed under Spinal Diseases.
Browse Spinal Diseases studies →Dartmouth-Hitchcock Medical Center is the lead sponsor of 488 studies on the registry; 71 are open to participants now.
Of its 31 completed or terminated interventional studies of FDA-regulated products, 21 (68%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Lidocaine infusion
Drug: Lidocaine in Saline
Normal saline infusion
Drug: Normal saline
Lidocaine infusion 1.5 mg/kg/hr
Also known as: Active
Normal saline infusion
Also known as: Placebo
Motor Evoked Potentials (MEPs)
An endpoint of the final stimulation threshold for MEPs at the end of surgery.
Time frame: Duration of the surgical procedure, no more than 24 hours
Somatosensory Evoked Potentials (SSEPs)
Endpoints of amplitude and latency throughout the surgery of SSEPs
Time frame: Duration of the surgical procedure, no more than 24 hours
Mean Arterial Pressure (MAP)
Intraoperative incidence of MAP \<65 mmHg and MAP \< 55 mmHg
Time frame: Duration of the surgical procedure, no more than 24 hours
Intraoperative propofol consumption
Rate of propofol consumption between the arms
Time frame: Duration of the surgical procedure, no more than 24 hours
Visual Analog Scale (VAS) Pain Scores
Endpoint of VAS pain scores post operative days (POD) 0/1/3
Time frame: Post-operative day 0 through 3
Opiod consumption
Opiod consumption converted to morphine equivalents through post operative day (POD) 3
Time frame: Post-operative day 0 through 3
Plan to share: No
This study is not yet recruiting, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Dartmouth-Hitchcock Medical Center →