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CompletedNCT06789133Updated Jan 23, 2025

Effects of Gait Training With and Without PNF on Balance ,Gait and Activities of Daily Living in Parkinson's Patients

An interventional study of PNF exercises and Body weight supported treadmill gait training and Body weight supported treadmill gait training and Routine physical therapy in Parkinson Disease (PD) and Proprioceptive Neuromuscular Facilitation, sponsored by Riphah International University. Completed at 1 site in Pakistan. Open to participants aged 45 Years to 65 Years. Per ClinicalTrials.gov, last updated 2025-01-23.

Sponsored by Riphah International University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 10 months after the study started (first participant enrolled Feb 2024, registered Dec 2024).
Phase
Not applicable
Study type
Interventional
Enrollment
36
Allocation
Randomized
Ages
45 Years to 65 Years
Sex
All
01

Study summary

Proprioceptive Neuromuscular Facilitation (PNF) and gait training exercises are specifically used to treat balance, gait and functional activities in Parkinson s patients. PNF has been compared with gait training and balance training in other conditions like stroke and multiple sclerosis but limited literatures are present in which PNF has been compared with gait training in Parkinson patients.

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Conditions studied

  • Parkinson Disease (PD)
  • Proprioceptive Neuromuscular Facilitation

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Keywords

  • PNF
  • PD
  • BWSTT
  • ADLs
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In context

Parkinson Disease

4,487 studies on the registry are indexed under Parkinson Disease; 1,082 are open to participants now.

This study's enrollment of 36 is close to the median of 40 across 3,294 interventional studies indexed under Parkinson Disease.

Browse Parkinson Disease studies →

Lead sponsor

Riphah International University is the lead sponsor of 2,133 studies on the registry; 633 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
45 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Parkinson's patients.
  • Patients from both gender around the age of 45-65.
  • Patient with a score of 42 above on the Berg Balance Scale.
  • Patients with shuffling gait
  • Patient with good cognitive function minimum score of 20 or more on Mini-mental Status Examination MMSE scale

Exclusion criteria

  • Patients with a history of CVA.
  • Patient with peripheral vascular disease.
  • Patient with fracture or dislocation of lower limb.
  • Patient with peripheral nerve injury
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
36 participants (actual)

Study arms

  • Experimental
    PNF exercises and Body weight supported treadmill gait training

    PNF exercises and Body weight supported treadmill gait training

    Other: PNF exercises and Body weight supported treadmill gait training

  • Active comparator
    Gait training without PNF

    Treadmil gait training and Routine physical therapy

    Other: Body weight supported treadmill gait training and Routine physical therapy

Interventions

  • OtherPNF exercises and Body weight supported treadmill gait training

    PNF Exercises: .Proprioceptive neuromuscular facilitation exercises include D1 Flexion and D1 Extension of lower limb ,D2 flexion D2 extension of lower limb .rhythmic initiation ,hold relax ,pelvic pattern and contract relax technique . subjects will perform each exercise for 30sec with resting interval of 30 to 60 seconds Will be provided after completion of each exercise. 3 sessions will be held per week, For 8 weeks Gait training: Body weight supported treadmill gait training for 20 minutes 3 sessions per week. In total all PNF exercises with gait training will be held for 40-45 minutes.

  • OtherBody weight supported treadmill gait training and Routine physical therapy

    Body Weight Supported Treadmill Training (BWSTT): This will include body weight supported treadmill gait training. 10 % BWSTT or 20% BWSTT. The session will of 20 minutes .3 sessions will be Held per week. Routine physical therapy: Stretching and strengthening of lower extremities In total all BWSTT along with routine physical therapy protocol will be held for 40-45minutes .3 sessions will be held per week.

06

What researchers measure

Primary outcomes

  1. Berg balance scale

    The Berg Balance Scale (BBS) is a test that measures a person's balance abilities by asking them to perform 14 simple tasks, such as standing, sitting, reaching, and turning. The test is scored on a scale from 0 to 56, with higher scores indicating better balance. The BBS is used to assess people who have balance impairments due to various conditions, such as stroke, Parkinson's disease, osteoarthritis, or inner ear problems. The BBS has been shown to have good reliability and validity for measuring balance in Ho The reliability and validity of this test is 0.95 or 95%

    Time frame: 4 weeks

  2. Time up and go Test

    from baseline :The Time Up and Go (TUG) test is a simple and quick test that measures a person's functional mobility and fall risk. The test involves standing up from a chair, walking 10 feet, turning around, walking back, and sitting down again, while timing how long it takes to complete the task. The TUG test is used to evaluate people who have balance impairments due to various conditions, such as aging, stroke, Parkinson's disease, or vestibular disorders. The TUG test also has some limitations. The reliability of this test is 0.97 to o.99.

    Time frame: 4 weeks

  3. Modified Barthel index

    The Barthel Index is a scale used to measure an individual's ability to perform activities of daily living. The Reliability of MBI is 0.73 to 0.77. It is often employed in healthcare settings to evaluate functional independence, guide rehabilitation plans, and monitor progress in patients. there are 10 items, each scored from 0 to 2 or 3 points, The total score ranges from 0 to 20 or 25, with higher scores indicating greater independence. The 10 items are: Bowel control Bladder control Grooming Toilet using Feeding Transfer (bed to chair and back) Mobility Dressing Stairs Bathing

    Time frame: 4 weeks

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Study locations

1 site
  • Arthritis and spine care , Lahore General hospital
    Lahore, Punjab 54000, Pakistan
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References and documents

Publications

  • Mazhar T, Jameel A, Sharif F, Asghar M. Effects of conventional physical therapy with and without proprioceptive neuromuscular facilitation on balance, gait, and function in patients with Parkinson's disease. J Pak Med Assoc. 2023 Jun;73(6):1280-1283. doi: 10.47391/JPMA.6710. PubMed 37427630 ↗
  • Giardini M, Nardone A, Godi M, Guglielmetti S, Arcolin I, Pisano F, Schieppati M. Instrumental or Physical-Exercise Rehabilitation of Balance Improves Both Balance and Gait in Parkinson's Disease. Neural Plast. 2018 Mar 7;2018:5614242. doi: 10.1155/2018/5614242. eCollection 2018. PubMed 29706993 ↗
  • Alexandre de Assis IS, Luvizutto GJ, Bruno ACM, Sande de Souza LAP. The Proprioceptive Neuromuscular Facilitation Concept in Parkinson Disease: A Systematic Review and Meta-Analysis. J Chiropr Med. 2020 Sep;19(3):181-187. doi: 10.1016/j.jcm.2020.07.003. Epub 2020 Dec 15. PubMed 33362441 ↗
  • Mak MKY, Wong-Yu ISK. Exercise for Parkinson's disease. Int Rev Neurobiol. 2019;147:1-44. doi: 10.1016/bs.irn.2019.06.001. Epub 2019 Jun 27. PubMed 31607351 ↗
  • Pelicioni PHS, Menant JC, Latt MD, Lord SR. Falls in Parkinson's Disease Subtypes: Risk Factors, Locations and Circumstances. Int J Environ Res Public Health. 2019 Jun 23;16(12):2216. doi: 10.3390/ijerph16122216. PubMed 31234571 ↗
  • Mirelman A, Bonato P, Camicioli R, Ellis TD, Giladi N, Hamilton JL, Hass CJ, Hausdorff JM, Pelosin E, Almeida QJ. Gait impairments in Parkinson's disease. Lancet Neurol. 2019 Jul;18(7):697-708. doi: 10.1016/S1474-4422(19)30044-4. Epub 2019 Apr 8. PubMed 30975519 ↗
  • Nonnekes J, Nieuwboer A. Towards Personalized Rehabilitation for Gait Impairments in Parkinson's Disease. J Parkinsons Dis. 2018;8(s1):S101-S106. doi: 10.3233/JPD-181464. PubMed 30584154 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 23, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06789133
Lead sponsor
Riphah International University
Responsible party
Sponsor
First posted
Jan 23, 2025
Start date
Feb 1, 2024
Primary completion
Oct 1, 2024
Completion
Nov 1, 2024
Last update
Jan 23, 2025

Study contacts

Arnab Altaf, MSDPT
principal investigator · Riphah International University

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jan 2025. You cannot join it, but the record below documents what was studied.

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