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CompletedNCT06786598Updated Jan 28, 2025

The Effect of Body Mass Index and Total Cholesterol Levels on Histopathological Grading in Breast Cancer Patients

An interventional study of Cholesterol in Breast Cancer, sponsored by Latakia University. Completed at 1 site in Syria. Open to female participants. Per ClinicalTrials.gov, last updated 2025-01-28.

Sponsored by Latakia University · Not applicable, Interventional, and Other

From the registry’s dates

  • Registered 2 years after the study started (first participant enrolled Jan 2023, registered Jan 2025).
Phase
Not applicable
Study type
Interventional
Enrollment
85
Allocation
Not applicable
Sex
Female
01

Study summary

Breast cancer is a widespread cancer that affects high percentiles of women worldwide.The development and aggressiveness of breast cancer cells can be evaluated depending on the histopathological grading which reflects the degree of differentiation. Several factors related to lifestyle can impact the development of breast cancer. Obesity is an important factor that received the attention in recent years. The using of body mass index(BMI) is still the common method for identifying obesity which is defined when having 30kg/m² or more. Previous epidemiological and clinical studies found that obesity was correlated with advanced breast cancer especially in postmenopausal patients . Also, the changes in cholesterol levels can influence breast cancer risk in the context of obesity. The findings of other studies is still controversial; many studies revealed that elevated total cholesterol levels could increase breast cancer risk while others found to have no effect. Due to the possibility of previous factors' effect on breast cancer progression, we purposed in this study to assess the association of BMI and total cholesterol with histopathological grading according to menopausal status among a group of breast cancer patients in Syria

02

Conditions studied

  • Breast Cancer

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03

In context

Breast Neoplasms

12,828 studies on the registry are indexed under Breast Neoplasms; 2,923 are open to participants now.

This study's enrollment of 85 is above the median of 72 across 9,498 interventional studies indexed under Breast Neoplasms.

Browse Breast Neoplasms studies →

Lead sponsor

Latakia University is the lead sponsor of 20 studies on the registry; 5 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
Female
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

all participants after ensurement that all their clinical and demoghraphical data are completed

Exclusion criteria

Exclusion Criteria:

metabolic syndromes, as well as patients with statin therapy and hormonal replacement treatment.

05

Study design

Phase
Not applicable
Primary purpose
Other
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
85 participants (actual)

Study arms

  • Experimental
    cholesterol titration

    Diagnostic Test: Cholesterol

Interventions

  • Diagnostic testCholesterol

    Qimica/kit

06

What researchers measure

Primary outcomes

  1. Evaluating The effect of body mass index and total cholesterol levels on histopathological grading in breast cancer patients

    Time frame: baseline

  2. Assessing the body mass index between patients via dividing weight(in killogram) by height (in meter squared)

    Time frame: baseline

07

Study locations

1 site
  • Tishreen university
    Latakia, Syria
08

References and documents

Publications

  • Llaverias G, Danilo C, Mercier I, Daumer K, Capozza F, Williams TM, Sotgia F, Lisanti MP, Frank PG. Role of cholesterol in the development and progression of breast cancer. Am J Pathol. 2011 Jan;178(1):402-12. doi: 10.1016/j.ajpath.2010.11.005. Epub 2010 Dec 23. PubMed 21224077 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 28, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06786598
Lead sponsor
Latakia University
Responsible party
Sponsor
First posted
Jan 22, 2025
Start date
Jan 1, 2023
Primary completion
Sep 1, 2023
Completion
Oct 1, 2023
Last update
Jan 28, 2025

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Dec 2024. You cannot join it, but the record below documents what was studied.

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Discussion

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