An interventional study of AI-based physiotherapy and Conventional physiotherapy in Oral Cancer, sponsored by National Taiwan University Hospital. Recruiting at 2 sites in Taiwan. Open to participants aged 20 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-04-03.
Sponsored by National Taiwan University Hospital · Not applicable, Interventional, and Treatment
This study examines the effects of AI-based physiotherapy on oral function, shoulder function, whole-body physical function, and quality of life in oral cancer patients. One hundred patients will be recruited before surgery, chemotherapy, or radiotherapy and randomly assigned to an experimental group receiving 12 weeks of AI-guided physiotherapy or a control group receiving usual care. Both groups will perform jaw, neck, and shoulder exercises, with the experimental group using a mobile app to monitor progress. Assessments at baseline, pre-intervention, and 3 months post-intervention will measure maximal in the maximum interincisal opening (MIO), joint range of motion (ROM), pain, endurance (e.g., 6-minute walk test), upper extremity function, and quality of life.
This study examines the effects of AI-based physiotherapy on oral function (e.g., mouth opening), shoulder function (e.g., shoulder joint range of motion and upper extremity function), whole-body physical function (e.g., 6-minute walk test), and health-related quality of life. 100 newly diagnosed oral cancer patients will be recruited before surgery, chemotherapy, or radiotherapy and randomly assigned to two groups. The experimental group will receive AI-based physiotherapy for 12 weeks, including postural correction exercises guided by AI technology, while the control group will receive usual care. Both groups will perform jaw, neck, and shoulder exercises, with the experimental group using a mobile app to monitor progress and record their exercise diaries. Assessments at baseline, pre-intervention, and 3 months post-intervention will measure the maximum interincisal opening (MIO), joint range of motion (ROM), pain, endurance, and upper extremity function using the Disabilities of the Arm, Shoulder, and Hand (DASH) scores, and quality of life using the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30).
377 studies on the registry are indexed under Mouth Neoplasms; 126 are open to participants now.
This study's planned enrollment of 100 is above the median of 65 across 265 interventional studies indexed under Mouth Neoplasms.
Browse Mouth Neoplasms studies →National Taiwan University Hospital is the lead sponsor of 2,563 studies on the registry; 569 are open to participants now.
Of its 11 completed or terminated interventional studies of FDA-regulated products, 2 (18%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
AI-based physiotherapy
Behavioral: AI-based physiotherapy · Behavioral: Scar management
Usual care
Behavioral: Conventional physiotherapy · Behavioral: Scar management
jaw, neck, shoulder ROM exercises, and scapular-focused exercises guided by AI technology, 30 minutes of intervention, once a week, and a total of 12 weeks
jaw, neck, shoulder ROM exercises, and scapular-focused exercises, 30 minutes of intervention, once a week, and a total of 12 weeks
scar massage and jaw-mobilizing exercises combined with devices or depressors
Change from baseline in maximal mouth opening
Average maximal mouth opening measured 3 times in mm
Time frame: baseline, pre-intervention, 3-months post-intervention
Change from baseline in shoulder joint range of motion
Average range of motion of shoulder abduction measured 3 times in degrees
Time frame: baseline, pre-intervention, 3-months post-intervention
Change from baseline in function on Disabilities of the Arm, Shoulder, and Hand outcome questionnaire
A total scale from 1 to 100. Higher scores indicate greater disability.
Time frame: baseline, pre-intervention, 3-months post-intervention
Change from baseline in health-related function on EORTC QLQ-C30 questionnaire
A total scale from 1 to 100. Higher scores indicate greater function.
Time frame: baseline, pre-intervention, 3-months post-intervention
Change from baseline in whole-body physical function on 6-minute walk test
Walking distance measured in meters.
Time frame: baseline, pre-intervention, 3-months post-intervention
Change from baseline in shoulder pain
Visual analog scale from 0 to 10. Higher scores indicate most pain.
Time frame: baseline, pre-intervention, 3-months post-intervention
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National Taiwan University Hospital