An observational study in Cholecystitis in Cirrhotic Patients, sponsored by Assiut University. Not yet recruiting. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2025-01-16.
Sponsored by Assiut University · Observational
To assess the outcome of posterior wall sparing of laparoscopic cholecystectomy in cirrhotic patients in Assuit university hospitals and El Rajhi hospital.
Cholelithiasis is found in about one third of patients with liver cirrhosis and about twice as much as in the overall population. Predisposing factors for that include functional gallbladder alterations (reduced motility and decreased emptying), reduction in bile acidity, increased unconjugated bilirubin secretion, increased levels of estrogen, and increased intravascular haemolysis due to hypersplenism. Symptomatic biliary stones in patients with liver cirrhosis are associated with higher morbidity and mortality rates than those in patients with a non-cirrhotic liver. laparoscopic cholecystectomy is the gold standard for the treatment of most of gallbladder problems because of its several advantages over open cholecystectomy including shorter convalescence period and hospital stay. Furthermore, considering its safety, it is the gold-standard procedure in selected patients with symptomatic cholelithiasis and hepatic cirrhosis, especially Child-Pugh score A and B patients. Separation of posterior wall of the gallbladder from the liver bed in cirrhotic individuals is difficult and risky during a laparoscopic cholecystectomy surgery because of high-risk gall bladder bed due to fibrosis and tortuous, dilated vessels there so the strategy is leaving the posterior wall intact with the liver and the remnant mucosa was removed either by mucosectomy in patients with acute cholecystitis or by electro fulguration in those with chronic cholecystitis.
266 studies on the registry are indexed under Cholecystitis; 46 are open to participants now.
This study's planned enrollment of 60 is below the median of 200 across 90 observational studies indexed under Cholecystitis.
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60 cirrhotic patients age from 18 to 60 years who were admitted for cholecystectomy
Exclusion Criteria:
To assess the outcome of posterior wall sparing of laparoscopic cholecystectomy in cirrhotic patient
Procedure: laparoscopic cholecystectomy
Posterior wall sparing of laparoscopic cholecystectomy in cirrhotic patients
Intra and Post-operative haemorrhage
Time frame: Surgery then 2 days follow up
Postoperative bile leak
Time frame: Surgery then 1 week follow up
Changes of liver function tests
AST, ALT, Billirubin
Time frame: Surgery then 1 week follow up
Worsening of ascites
Time frame: Surgery then 1 week follow up
Port site infection
Time frame: Surgery then 1 week folow up
Operative time
Time frame: From the end of induction of anasthesia to the closure of port site incisions
Postoperative hospital stay
Time frame: surgery then up to 1 week hospital stay before discharge
No study locations are listed for this record.
Plan to share: Undecided
This study is not yet recruiting, as verified in Oct 2024. You cannot join it, but the record below documents what was studied.
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Assiut University