An observational study in Aortic Stenosis, sponsored by Yale University. Enrolling by invitation at 3 sites in United States. Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2026-05-08.
Sponsored by Yale University · Observational
This study will evaluate the validity of a digital biomarker score for precision risk stratification among older adults with aortic sclerosis or mild aortic stenosis (AS) at three US health systems.
985 studies on the registry are indexed under Aortic Valve Stenosis; 283 are open to participants now.
This study's planned enrollment of 210 is close to the median of 200 across 424 observational studies indexed under Aortic Valve Stenosis.
Browse Aortic Valve Stenosis studies →Yale University is the lead sponsor of 1,725 studies on the registry; 299 are open to participants now.
Of its 210 completed or terminated interventional studies of FDA-regulated products, 126 (60%) have results posted.
Counted across the registry records on this site, refreshed daily.
US adults aged 65 and older with an echocardiogram within the prior 2-3 years that showed aortic sclerosis without stenosis or mild aortic stenosis (AS).
Exclusion Criteria:
All study participants will undergo a clinical transthoracic echocardiogram (TTE) performed by certified echocardiography technicians. The TTE includes standard transthoracic examination with acquisition of B-mode, color and spectral Doppler images and videos in line with standard echocardiographic guidelines.
Annualized change in AV Vmax in m/sec/years
The primary outcome measure is the annualized change in AV Vmax in m/sec/years, defined as the absolute difference between the value on the enrollment and baseline echocardiogram measurement, divided by the time difference between the studies.
Time frame: From baseline TTE to TTE performed at enrollment
Plan to share: Yes — A de-identified dataset will be made available following publication of primary results.
Supporting information: Study protocol, Sap, Icf, Analytic code
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