A Prospective, Open-label, Single-arm Phase II Clinical Study of Fruquintinib Combined With S-1 for the Treatment of Metastatic Colorectal Cancer.

1. Fully understand this study and voluntarily sign the informed consent form;
2. Age ≥18 years, gender not limited;
3. Confirmed advanced metastatic colorectal adenocarcinoma by histopathological examination;

4. Patients have previously received at least one line of standard therapy containing fluorouracil, oxaliplatin, and irinotecan, and have progressed or are intolerant.

   • Each line of treatment must include one or more chemotherapy drugs for a duration of ≥1 cycle;
   • Adjuvant/neoadjuvant therapy is allowed. If recurrence or metastasis occurs during or within 6 months after completion of adjuvant/neoadjuvant therapy, it is considered a failure of first-line chemotherapy for progressive disease;
   • Prior use of chemotherapy combined with cetuximab or bevacizumab in antitumor treatment regimens is allowed;
5. At least one measurable lesion (RECIST 1.1 criteria);
6. ECOG performance status 0-1;
7. Expected survival time ≥12 weeks;

8. Within 14 days before enrollment, the function of major organs must meet the following requirements (no use of any blood components and cell growth factors within 14 days before enrollment):

   • Absolute neutrophil count ≥1.5×10\^9/L;
   • Platelet count ≥80×10\^9/L;
   • Hemoglobin ≥8g/dL;
   • Total bilirubin \<1.5 times the upper limit of normal (ULN);
   • ALT and AST \<2.5 times ULN (\<5 times ULN for patients with liver metastasis);
   • Serum creatinine ≤1 times ULN;
   • Endogenous creatinine clearance rate >50ml/min;
9. Women of childbearing age or men with partners who wish to have children must use effective contraceptive measures;
10. Agree to provide blood samples.

Exclusion Criteria:

1. Have previously received treatment with fruquintinib or other anti-VEGFR (vascular endothelial growth factor receptor) inhibitors such as apatinib, regorafenib, and anlotinib;
2. Have previously received treatment with tegafur;
3. Have participated in another drug clinical trial within four weeks before enrollment and received at least one dose of medication, or have received other systemic antitumor treatments, including chemotherapy, signal transduction inhibitors, hormone therapy, and immunotherapy within four weeks before enrollment;
4. Patients currently have diseases or conditions that affect drug absorption, or patients are unable to orally take fruquintinib;
5. Patients currently have active gastric and duodenal ulcers, ulcerative colitis, and other gastrointestinal diseases, or have active bleeding from unresected tumors, or other conditions that may cause gastrointestinal bleeding or perforation as judged by the investigator;
6. Have active bleeding or bleeding tendencies;
7. Have uncontrollable malignant pleural effusion, ascites, or pericardial effusion (defined as not effectively controlled by diuretics or puncture as judged by the investigator);

8. Have a history of severe cardiovascular and cerebrovascular diseases:

   • Cerebral vascular accidents (except for lacunar infarction, minor cerebral ischemia, or transient cerebral ischemic attacks), myocardial infarction, unstable angina, poorly controlled arrhythmias (including QTc interval for males ≥ 450ms, females ≥ 470ms) (QTc interval calculated using the Fridericia formula) within 6 months before the first dose of the study drug;
   • New York Heart Association (NYHA) heart function classification > II or left ventricular ejection fraction (LVEF) \< 50%;
9. Have had other malignancies in the past 5 years, except for skin basal cell or squamous cell carcinoma after radical surgery, or cervical carcinoma in situ;
10. Have clinically uncontrolled active infections, such as acute pneumonia, active hepatitis B or C (history of hepatitis B virus infection not under drug control, HBV DNA ≥1×10\^4 copies/mL or >2000 IU/mL);
11. Have clinically symptomatic central nervous system metastases and/or meningeal carcinomatosis;
12. Patients currently have uncontrolled hypertension with medication, defined as: systolic blood pressure ≥150 mmHg and/or diastolic blood pressure ≥100 mmHg after taking antihypertensive drugs;
13. Urinalysis indicates urinary protein ≥2+, and re-examined 24-hour urinary protein quantity >1.0g;
14. Pregnant (positive pregnancy test before medication) or breastfeeding women;
15. The investigator judges that there are clinically significant severe electrolyte abnormalities, or the investigator believes that the patient is unsuitable for participation in this clinical study for other reasons.