An interventional study of self-monitoring of breath acetone and lifestyle-intervention via LIM-App in Overweight and Obese Volunteers, sponsored by West German Center of Diabetes and Health. Active, not recruiting at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-10.
Sponsored by West German Center of Diabetes and Health · Not applicable, Interventional, and Supportive care
Among 149 studies in Overweight with a site in Germany — 38 open to participants now, 60 under way, 34 of them phase 3. Overweight · Germany.
Among the 149 studies in Overweight with a site in Germany, this one is the 120th largest by planned enrollment of the 141 interventional ones that give a count, is one of 25 that started in 2025, is one of 52 with no phase, reaches primary completion later than 29 of the 59 other live ones, and was the 91st registered.
3,599 studies on the registry are indexed under Overweight; 852 are open to participants now.
Browse Overweight studies →38 of the 149 studies in Overweight with a site in Germany are open now. Recruiting first, the newest first:
Eli Lilly and Company · Sites in Germany, United States, Brazil and 7 more countries
Novo Nordisk A/S · Sites in Germany
Boehringer Ingelheim · Sites in Germany
German Diabetes Center · Sites in Germany
Buchinger Wilhelmi Development & Holding GmbH · Sites in Germany
A study can be open while its sites in Germany have not opened yet or have stopped. Only those recruiting at a site in Germany →
Of the 529 Overweight studies recruiting now, 158 (30%) set no upper age limit and 343 (65%) stop at 75 or younger; 62 take children under 18; 204 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
149 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 26 · Phase 2 10 · Phase 3 48 · Phase 4 6
First in 2004; this study’s year is marked. 25 started in 2025.
This study's planned enrollment of 42 is below the median of 78 across 3,120 interventional studies indexed under Overweight.
Median enrollment 137 across the 141 interventional studies, 275 across the 8 observational. Of the 81 that completed or were terminated, 13 (16%) have results posted.
This tab as a report to print or save as PDF → With an account.
97 of 149 have an industry lead sponsor. The 10 most frequent:
West German Center of Diabetes and Health is the lead sponsor of 18 studies on the registry; 1 is open to participants now.
West German Center of Diabetes and Health has 7 studies filed under Overweight — fewer than ten, so there is no comparison to draw.
24 of the studies in Overweight with a site in Germany that are under way reach primary completion within a year, 12 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06914895Phase 3Eli Lilly and CompanyA Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight | 2026-11 |
| NCT06858839Phase 3AmgenEvaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight | 2027-01-21 |
| NCT06858878Phase 3AmgenEfficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight | 2027-01-21 |
| NCT07220642Phase 3Novo Nordisk A/SWeight Loss in People Living With Overweight or Obesity Following Treatment With Cagrilintide | 2027-05-11 |
| NCT06993792Phase 3Eli Lilly and CompanyA Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes | 2027-08 |
Among the 149 studies in Overweight with a site in Germany, from their registry updates:
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The goal of this clinical trial is to learn if lifestyle intervention with information about ketosis state supports weight reduction in overweight adults.
Researchers will compare an App-based lifestyle intervention with self-monitoring of breath acetone vs. lifestyle intervention alone.
Participants will:
Get a lifestyle intervention via the LIM-App for 12 months. Report body weight.
Background: Overweight and obesity are an increasing problem. Therefore, the Low-Insulin-Method was developed to support overweight and obese people in weight loss.
Method: In a randomized controlled clinical trial, the effect of the lifestyle intervention program 'Low-Insulin-Method', delivered by the Low-Insulin-App including low-carb diet, physical activity, self monitoring of weight, and self-monitoring of breath acetone (SMBA) is examined compared to a control group without information about ketosis level. Weight change will be compared after 3 and 12 months.
Objective: The aim is to develop a training and counseling program for overweight or obese individuals with diabetes risk or type 2 diabetes, which can be used both for primary and for tertiary prevention of overweight-related diseases.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
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Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
lifestyle intervention including information about ketosis level
Other: self-monitoring of breath acetone · Other: lifestyle-intervention via LIM-App
lifestyle intervention without information about ketosis level
Other: lifestyle-intervention via LIM-App
Participants perform self-monitoring of braeth acetone in order to get information about their ketosis state.
Participants are offered a lifestyle intervention via LIM-App.
body weight
body weight in kg
Time frame: 3 months
body weight
body weight in kg
Time frame: 12 months
Plan to share: No — upon request
No publications or documents are linked to this record.
Started Jan 2025 (actual). Primary completion is estimated for Dec 2027, 35 months after the start.
Of 1,300 non-industry interventional studies with no phase under Overweight, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 38. This study's planned 35 months is above that.
Counting every sponsor, half of 1,411 studies reached it within 17 months; a quarter within 8 and three quarters within 38.
How these figures are worked out, and which studies are left out of them.
This study is active, not recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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West German Center of Diabetes and Health