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RecruitingNCT06735027Updated Jan 8, 2026

Corticosteroid Injection Versus Nerve Block

An interventional study of intraarticular corticosteroid injection (IACI) and suprascapular nerve block (SSNB) in Glenohumeral Arthritis and Rotator Cuff Arthropathy, sponsored by University of Minnesota. Recruiting at 1 site in United States. Open to participants aged 18 Years to 99 Years. Per ClinicalTrials.gov, last updated 2026-01-08.

Sponsored by University of Minnesota · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Started Jan 2025; still recruiting 1 year 9 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
18 Years to 99 Years
Sex
All
01

Study summary

The purpose of this study is to evaluate conservative pain relief measures for patients suffering from glenohumeral arthritis or rotator cuff arthropathy. Conservative management of osteoarthritis is often first line treatment, and while a corticosteroid injection is frequently used, suprascapular nerve blocks have not often been described as an analgesic option in this population.

02

Conditions studied

  • Glenohumeral Arthritis
  • Rotator Cuff Arthropathy

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Keywords

  • osteoarthritis
  • glenohumeral arthritis
  • rotator cuff arthropathy
  • corticosteroid injection
  • suprascapular nerve block
03

In context

Osteoarthritis

4,398 studies on the registry are indexed under Osteoarthritis; 582 are open to participants now.

This study's planned enrollment of 40 is below the median of 70 across 3,440 interventional studies indexed under Osteoarthritis.

Browse Osteoarthritis studies →

Lead sponsor

University of Minnesota is the lead sponsor of 1,184 studies on the registry; 195 are open to participants now.

Of its 132 completed or terminated interventional studies of FDA-regulated products, 91 (69%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 99 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • diagnosis of glenohumeral osteoarthritis, rheumatoid arthritis, or rotator cuff arthropathy who are being offered injection

Exclusion criteria

Exclusion Criteria:

  • uncontrolled diabetes (patients will be excluded if no HbA1c within a year or if it is 8 or greater"
  • known allergy to steroid or anesthetic
  • pregnant women
  • prisoners
  • patients with diminished capacity to consent to participation
  • children under 18 years of age
  • non-English speakers
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Investigator, Outcomes assessor)
Enrollment
40 participants (estimated)

Study arms

  • Experimental
    intraarticular methylprednisolone acetate injection (IACI)

    Patients with glenohumeral osteoarthritis, rheumatoid arthritis, or rotator cuff arthropathy who are poor surgical candidates or who are not interested in pursuing surgery randomized to intraarticular corticosteroid injection (IACI).

    Other: intraarticular corticosteroid injection (IACI)

  • Experimental
    suprascapular nerve block (SSNB) with bupivacaine and triamcinolone

    Patients with glenohumeral osteoarthritis, rheumatoid arthritis, or rotator cuff arthropathy who are poor surgical candidates or who are not interested in pursuing surgery randomized to suprascapular nerve block (SSNB)

    Other: suprascapular nerve block (SSNB)

Interventions

  • Otherintraarticular corticosteroid injection (IACI)

    The patient will be in a seated position. Correct patient, laterality, and procedure will be performed during the timeout. Ultrasound guidance will be used to identify the glenohumeral joint. The injection site will then be disinfected with an alcohol wipe. A 21, 22, or 23-gauge needle (depending on provider preference) will be advanced into the glenohumeral joint under direct ultrasound visualization. After entry into the glenohumeral joint, a negative aspiration will be performed. At that time, up to 1 mL of 40mg/mL methylprednisolone acetate will be injected be injected into the joint space.

  • Othersuprascapular nerve block (SSNB)

    The patient will be in a seated position. Correct patient, laterality, and procedure will be performed during the timeout. Ultrasound guidance will be used to identify the suprascapular nerve in its path at the suprascapular notch. After disinfection of the injection site with alcohol, anatomic landmarks for SSNB as described by Dangoisse et al. \[10\] will be marked with a marking pen. Ultrasound will be utilized to guide the tip of a 21, 22, or 23 gauge (depending on provider preference) needle to the floor of the suprascapular fossa while avoiding neurovascular structures. At that time, a mixture of up to 10 mL of 0.5% bupivacaine and 20 mg triamcinolone will be slowly injected to fill the fascial contents of the suprascapular fossa under direct ultrasound guidance.

06

What researchers measure

Primary outcomes

  1. change in visual analog scale (VAS) for pain

    a validated continuous scale assessment for pain

    Time frame: preintervention, 24 hours, 3 days, 1 month, and 3 months postintervention

  2. single assessment numerical evaluation (SANE) of the shoulder

    a validated tool providing a numerical score from 0-100 that assess shoulder function as subjectively reported by the subject. A higher score indicates superior shoulder function.

    Time frame: preintervention, 24 hours, 3 days, 1 month, and 3 months postintervention

  3. Oxford shoulder score (OSS)

    a validated patient-reported outcome measure used to assess shoulder pain and functional disability. Possible scores range from 0-48 with higher scores indicating superior better shoulder function.

    Time frame: preintervention, 24 hours, 3 days, 1 month, and 3 months postintervention

  4. American shoulder and elbow surgeons (ASES) score

    a validated survey with possible scores from 0-100 that assesses shoulder function as reported by the subject. A higher score indicates superior shoulder function.

    Time frame: preintervention, 24 hours, 3 days, 1 month, and 3 months postintervention

07

Study locations

1 of 1 sites recruiting
  • University of Minnesota
    Minneapolis, Minnesota 55414, United States
    • Allison Rao · Contact
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 8, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06735027
Lead sponsor
University of Minnesota
Responsible party
Sponsor
First posted
Dec 16, 2024
Start date
Jan 2, 2025
Primary completion
Jan 2, 2027 (estimated)
Completion
Jan 2, 2027 (estimated)
Last update
Jan 8, 2026

Study contacts

Allison Rao
Contact
rao00149@umn.edu
608-445-0545
Allison Rao, MD
principal investigator · University of Minnesota

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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