An interventional study of Laparoscopic Presacral Neurectomy and Fluoroscopically guided Superior Hypogastric Plexus Neurolysis in Pain, Chronic, sponsored by Zagazig University. Active, not recruiting at 1 site in Egypt. Open to female participants aged 21 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-05-06.
Sponsored by Zagazig University · Not applicable, Interventional, and Treatment
Chronic pelvic pain remains a challenging disorder to treat because of the complexities of pain sensation and unclear etiology. Standard medical and surgical treatments seldom prove effective at improving quality of life and pain intensity among affected women.
Chronic pelvic pain remains a challenging disorder to treat because of the complexities of pain sensation and unclear etiology. Standard medical and surgical treatments seldom prove effective at improving quality of life and pain intensity among affected women. The current study will investigate whether Laparoscopic Presacral Neurectomy or Fluoroscopically Guided Superior Hypogastric Plexus Neurolysis is more effective for treating chronic pelvic pain.
2,928 studies on the registry are indexed under Chronic Pain; 699 are open to participants now.
This study's enrollment of 62 is close to the median of 60 across 2,160 interventional studies indexed under Chronic Pain.
Browse Chronic Pain studies →Zagazig University is the lead sponsor of 447 studies on the registry; 75 are open to participants now.
Of its 5 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
The patients will undergo Laparoscopic Presacral Neurectomy under general anesthesia.
Procedure: Laparoscopic Presacral Neurectomy
The patients will receive fluoroscopically guided Superior Hypogastric Plexus Neurolysis with Radiofrequency of the Sacral Roots 2,3,4.
Procedure: Fluoroscopically guided Superior Hypogastric Plexus Neurolysis
Laparoscopy will be performed under general anesthesia. Then, nerve plexuses will be identified and freed from their underlying tissue, which contains the left common iliac and middle sacral veins. This will be followed by cauterization and cutting of the nerve plexuses.
The patients will receive fluoroscopically guided Superior Hypogastric Plexus Neurolysis using 3 mL of 75% ethanol and Radiofrequency of the Sacral nerve Roots 2-4.
Visual analogue pain score
The percentage of patients who achieved \> 50% decline in their Visual analogue pain score "from the baseline value" before intervention at the end of the first month.
Time frame: At the end of the first month after the procedure.
Daily analgesic requirements
Daily analgesic requirements at the end of the first 2 weeks, 1st month, 2nd month, 3rd month, and 6th month after the procedure.
Time frame: At the end of the first 2 weeks, 1st month, 2nd month, 3rd month, and 6th month after the procedure.
Associated adverse events
Any related adverse events "e.g. hypotension, bleeding or neurological deficits" in the first month after the procedure.
Time frame: At the end of the first month after the procedure.
This study is active, not recruiting, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
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Zagazig University