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RecruitingNCT06707441TTSS/TRISS/ERUpdated Mar 4, 2026

Thorax vs. Trauma Injury Severity Scores as Outcome Predictors in Chest Trauma

An observational study in Chest Trauma, sponsored by Al-Nahrain University. Recruiting at 1 site in Iraq. Open to participants aged 16 Years and older. Per ClinicalTrials.gov, last updated 2026-03-04.

Sponsored by Al-Nahrain University · Observational

From the registry’s dates

  • Started Jan 2025; still recruiting 1 year 9 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
150
Ages
16 Years and older
Sex
All
01

Study summary

The goal of this observational study is to compare the predictive utility of the Thorax Trauma Severity Score (TTSS) and the Trauma and Injury Severity Score (TRISS) in determining outcomes among patients presenting with chest trauma to the emergency room. The main questions it aims to answer are:

Does the TTSS provide a more accurate prediction of patient outcomes (e.g., mortality, ICU admission) than the TRISS? Are there specific patient subgroups where one score is more effective than the other?

Participants will:

Have their chest trauma severity assessed using both TTSS and TRISS during their emergency room admission.

Have their clinical outcomes (e.g., mortality, ICU admission, length of hospital stay) monitored throughout their hospital stay.

Read the detailed description

Trauma is a significant cause of mortality and morbidity around the world. Approximately 10% of the burden of disease in adults is due to traumatic injuries. Trauma can lead to serious consequences, including disabilities, psychosocial burdens, and increased mortality among the actively working population. Cardiopulmonary arrest, unplanned admissions to intensive care units, and nosocomial infections are some complications faced by trauma patients admitted to trauma centers. The estimated mortality rate for hospitalized trauma patients is 11%. The in-hospital mortality rate for trauma patients who undergo cardiopulmonary resuscitation (CPR) is 92.7%. Trauma-related mortality and morbidity depend on injury severity, diagnostic delays, and the time taken to reach a medical facility. Timely evaluation, effective post-trauma care, and appropriate triage can significantly reduce long-term mortality and morbidity among trauma patients, with rapid assessment of trauma severity being crucial for the primary triage of multiple trauma patients.

Trauma scoring systems are essential tools in the medical field for evaluating the severity of injuries and predicting patient outcomes. Two notable scoring systems are the Thorax Trauma Severity Score (TTSS) and the Trauma and Injury Severity Score (TRISS), each serving unique purposes in assessing thoracic injuries and overall trauma severity. The TTSS was developed to provide a comprehensive assessment of thoracic injuries by incorporating both anatomical and physiological parameters. It specifically focuses on various aspects of chest trauma, including:

Age of the patient Ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2) Presence of pleural injuries Lung contusions Rib fractures The scoring system ranges from 0 to 25 points, where higher scores indicate more severe injuries and worse prognoses. Research has shown that a TTSS score of 7 or above is highly predictive of morbidity and mortality, achieving 100% sensitivity and 97.73% specificity for poor outcomes in isolated thoracic trauma cases. The TRISS is another critical scoring system used to evaluate overall injury severity across multiple body regions. It is based on the Injury Severity Score (ISS), which categorizes injuries according to their anatomical location using the Abbreviated Injury Scale (AIS). The ISS is calculated by taking the highest AIS scores from the three most severely injured body regions, squaring them, and summing these values.

Despite their utility, both TTSS and TRISS have limitations, especially when applied to diverse patient populations. The TTSS may not adequately account for the severity of injuries outside the thoracic region, which can significantly impact patient outcomes. For instance, a study highlighted that in patients with an Injury Severity Score (ISS) greater than 15, only 44% had a TTSS above 8, indicating that critical extra-thoracic injuries were not reflected in the TTSS scoring. Older patients or those with comorbidities may present with less obvious thoracic injuries that the TTSS fails to identify. This oversight can lead to underestimating the risk of complications or mortality, as older individuals often have a higher propensity for severe outcomes despite seemingly minor trauma. The TISS may not capture specific details related to chest trauma effectively. This limitation is crucial in regions with variable healthcare infrastructure, like Iraq, where injury mechanisms and patient demographics can differ widely. The TRISS's general approach may overlook critical factors that influence trauma severity in these populations.

This study seeks to address the specific needs of the Iraqi healthcare system by comparing the TTSS and TRISS as predictive tools for chest trauma outcomes in emergency settings. The aim is to identify which scoring system is more reliable and practical for use in Iraq, considering the unique challenges faced by emergency departments, such as high patient volumes and resource constraints. The research fills a critical gap in the literature by providing data specific to Iraq, where comparative analyses of these scoring systems are lacking. Insights gained from this study could inform local protocols, enhance triage efficiency, and improve patient outcomes in Iraqi emergency departments .

02

Conditions studied

  • Chest Trauma

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Keywords

  • TTSS
  • ER
  • TRISS
03

In context

Thoracic Injuries

72 studies on the registry are indexed under Thoracic Injuries; 18 are open to participants now.

This study's planned enrollment of 150 is close to the median of 150 across 32 observational studies indexed under Thoracic Injuries.

Browse Thoracic Injuries studies →

Lead sponsor

Al-Nahrain University is the lead sponsor of 26 studies on the registry; 20 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
16 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

The study population will consist of adult patients (18 years and older) who present to the Emergency Department (ER) of Al-Kadhimiya Teaching Hospital with chest trauma. This population will be classified based on the severity of their injuries, ranging from minor to critical, and include both blunt and penetrating trauma cases.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients with chest injuries that require clinical assessment using the Thorax Trauma Severity Score (TTSS) and the Trauma Injury Severity Score (TISS) within 6 hours of admission.
  • Patients (or their legal guardians) must provide for participation in the study. This ensures ethical standards are maintained.
  • Patients presenting with thoracic injuries, including rib fractures, pulmonary contusions, pneumothorax, hemothorax, and other chest-related injuries. This will include both isolated chest trauma and trauma with multiple injuries

Exclusion criteria

Exclusion Criteria:

  • Patients younger than 16 years.
  • Patients with chest injuries caused by conditions unrelated to trauma, such as spontaneous pneumothorax, infections, or other medical conditions (e.g., non-traumatic rib fractures or cancer).
  • Patients with severe co-morbidities (e.g., terminal illnesses, advanced stages of cancer, or end-stage organ failure) that would significantly affect outcomes unrelated to the chest trauma.
  • Patients with pre-existing severe neurological conditions or other comorbidities that would interfere with trauma assessment and clinical management (e.g., severe brain injury, vegetative state).
  • Patients or their legal representatives who refuse consent for participation in the study.
  • Pregnant women due to potential risks associated with trauma and interventions during pregnancy.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
150 participants (estimated)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. In hospital mortality

    Mortality (death) during hospitalization.

    Time frame: In-Hospital Phase (average of 7-10 days through discharge)

  2. Accuracy Assessment of Thorax Trauma Severity Score (TTSS)

    Range: from 0 to 25, with higher scores indicating more severe thoracic trauma.

    Time frame: the first 6 hours after ER admission

  3. Accuracy Assessment of Trauma and Injury Severity Score (TRISS)

    Range: 0 (represents a 0% probability of survival) to 1 (represents a 100% probability of survival), with higher scores indicating greater trauma severity.

    Time frame: the first 6 hours after ER admission

Secondary outcomes

  1. Length of Hospitalization

    Description: The total duration of a patient's stay in the hospital, measured from the date of admission to the date of discharge. This includes all days spent in general wards, intensive care units (ICU), and other hospital departments as part of their treatment course.

    Time frame: Up to discharge, an average of 7-10 days

  2. Rate of admission to the intensive care unit (ICU)

    The requirement for admission to the intensive care unit (ICU) is determined by the presence of severe clinical deterioration, significant complications, or the need for advanced monitoring and life-support measures.

    Time frame: Up to discharge, an average of 7-10 days

07

Study locations

1 of 1 sites recruiting
  • College of Medicine - Al-Nahrain University
    Baghdad, Iraq
    Recruiting
    • Yaser aamer Eisa Alhaibi, Assistant professor · Contactyaseraamer@nahrainuniv.edu.iq · 009647705051684
    • Abdulillah R. Khamees · Principal investigator
    • Ghefar Hmaydoosh, MD · Sub investigator
    • Ghadeer mohammed, MD · Sub investigator
    • Ibrahim Moqbel, Student · Sub investigator
    • Ali R. Turki, Student · Sub investigator
    • Abdullah ali ghareeb, MBBCH · Sub investigator
    • Sajjad sadiq salman, Lecturer · Sub investigator
    • Salim K. Hajwal, Lecturer · Sub investigator
08

References and documents

Publications

  • Indurkar SK Sr, Ghormade PS, Akhade S, Sarma B. Use of the Trauma and Injury Severity Score (TRISS) as a Predictor of Patient Outcome in Cases of Trauma Presenting in the Trauma and Emergency Department of a Tertiary Care Institute. Cureus. 2023 Jun 14;15(6):e40410. doi: 10.7759/cureus.40410. eCollection 2023 Jun. PubMed 37456404 ↗
  • Zahran, M.R., Elwahab, A.A.E.M.A., El Nasr, M.M.A. et al. Evaluation of the predictive value of thorax trauma severity score (TTSS) in thoracic-traumatized patients. Cardiothorac Surg 28, 3 (2020). https://doi.org/10.1186/s43057-020-0015-7
  • Imhoff BF, Thompson NJ, Hastings MA, Nazir N, Moncure M, Cannon CM. Rapid Emergency Medicine Score (REMS) in the trauma population: a retrospective study. BMJ Open. 2014 May 2;4(5):e004738. doi: 10.1136/bmjopen-2013-004738. PubMed 24793256 ↗
  • Karajizadeh M, Nasiri M, Yadollahi M, Zolfaghari AH, Pakdam A. Mortality Prediction from Hospital-Acquired Infections in Trauma Patients Using an Unbalanced Dataset. Healthc Inform Res. 2020 Oct;26(4):284-294. doi: 10.4258/hir.2020.26.4.284. Epub 2020 Oct 31. PubMed 33190462 ↗
  • Konesky KL, Guo WA. Revisiting traumatic cardiac arrest: should CPR be initiated? Eur J Trauma Emerg Surg. 2018 Dec;44(6):903-908. doi: 10.1007/s00068-017-0875-6. Epub 2017 Nov 25. PubMed 29177620 ↗
  • Mulvey HE, Haslam RD, Laytin AD, Diamond CA, Sims CA. Unplanned ICU Admission Is Associated With Worse Clinical Outcomes in Geriatric Trauma Patients. J Surg Res. 2020 Jan;245:13-21. doi: 10.1016/j.jss.2019.06.059. Epub 2019 Aug 5. PubMed 31394403 ↗
  • Todd KH, Lee T, Hoffman JR. The effect of ethnicity on physician estimates of pain severity in patients with isolated extremity trauma. JAMA. 1994 Mar 23-30;271(12):925-8. PubMed 8120961 ↗
  • Mondello S, Cantrell A, Italiano D, Fodale V, Mondello P, Ang D. Complications of trauma patients admitted to the ICU in level I academic trauma centers in the United States. Biomed Res Int. 2014;2014:473419. doi: 10.1155/2014/473419. Epub 2014 Jun 3. PubMed 24995300 ↗
  • Ramos-Pascua LR. Complications and trauma sequelae. Injury. 2018 Sep;49 Suppl 2:S1-S2. doi: 10.1016/j.injury.2018.06.045. Epub 2018 Jul 7. No abstract available. PubMed 30097308 ↗
  • Haagsma JA, Graetz N, Bolliger I, Naghavi M, Higashi H, Mullany EC, Abera SF, Abraham JP, Adofo K, Alsharif U, Ameh EA, Ammar W, Antonio CA, Barrero LH, Bekele T, Bose D, Brazinova A, Catala-Lopez F, Dandona L, Dandona R, Dargan PI, De Leo D, Degenhardt L, Derrett S, Dharmaratne SD, Driscoll TR, Duan L, Petrovich Ermakov S, Farzadfar F, Feigin VL, Franklin RC, Gabbe B, Gosselin RA, Hafezi-Nejad N, Hamadeh RR, Hijar M, Hu G, Jayaraman SP, Jiang G, Khader YS, Khan EA, Krishnaswami S, Kulkarni C, Lecky FE, Leung R, Lunevicius R, Lyons RA, Majdan M, Mason-Jones AJ, Matzopoulos R, Meaney PA, Mekonnen W, Miller TR, Mock CN, Norman RE, Orozco R, Polinder S, Pourmalek F, Rahimi-Movaghar V, Refaat A, Rojas-Rueda D, Roy N, Schwebel DC, Shaheen A, Shahraz S, Skirbekk V, Soreide K, Soshnikov S, Stein DJ, Sykes BL, Tabb KM, Temesgen AM, Tenkorang EY, Theadom AM, Tran BX, Vasankari TJ, Vavilala MS, Vlassov VV, Woldeyohannes SM, Yip P, Yonemoto N, Younis MZ, Yu C, Murray CJ, Vos T. The global burden of injury: incidence, mortality, disability-adjusted life years and time trends from the Global Burden of Disease study 2013. Inj Prev. 2016 Feb;22(1):3-18. doi: 10.1136/injuryprev-2015-041616. Epub 2015 Dec 3. PubMed 26635210 ↗
  • GBD 2021 Causes of Death Collaborators. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2024 May 18;403(10440):2100-2132. doi: 10.1016/S0140-6736(24)00367-2. Epub 2024 Apr 3. PubMed 38582094 ↗
  • Lafta RK, Al-Nuaimi MA. National perspective on in-hospital emergency units in Iraq. Qatar Med J. 2013 Nov 1;2013(1):19-27. doi: 10.5339/qmj.2013.4. eCollection 2013. PubMed 25003053 ↗
  • Donaldson RI, Shanovich P, Shetty P, Clark E, Aziz S, Morton M, Hasoon T, Evans G. A survey of national physicians working in an active conflict zone: the challenges of emergency medical care in Iraq. Prehosp Disaster Med. 2012 Apr;27(2):153-61. doi: 10.1017/S1049023X12000519. Epub 2012 May 17. PubMed 22591705 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 4, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06707441
Lead sponsor
Al-Nahrain University
Responsible party
Abdulillah R. Khamees (Principal Investigator, Al-Nahrain University) — Principal investigator
First posted
Nov 27, 2024
Start date
Jan 20, 2025
Primary completion
Dec 10, 2026 (estimated)
Completion
Dec 20, 2026 (estimated)
Last update
Mar 4, 2026

Study contacts

Abdulillah R. Khamees
Contact
allaabed987@ced.nahrainuniv.edu.iq
+9647838571013
Yaser aamer Eisa Alhaibi, Assistant professor
study director · College Of Medicine - Nahrain University

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

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