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Active, not recruitingNCT06697730SIPARIO-1Updated Mar 27, 2026

Study of the Incidence and Prognosis of Intrahospital Acute Kidney Injury

An observational study in Acute Kidney Injury, sponsored by Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico. Active, not recruiting at 1 site in Italy. Per ClinicalTrials.gov, last updated 2026-03-27.

Sponsored by Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
43,000
Sex
All
01

Study summary

The goal of this observational study is to investigate the epidemiology of acute kidney injury in hospitalized patients. The main question it aims to answer is: how frequent is the development of acute kidney injury in patients who are hospitalized? Data from participants will be retrospectively collected from medical charts.

02

Conditions studied

  • Acute Kidney Injury

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Keywords

  • acute kidney injury
  • hospitalized
03

In context

Acute Kidney Injury

1,595 studies on the registry are indexed under Acute Kidney Injury; 371 are open to participants now.

This study's planned enrollment of 43,000 is above the median of 150 across 773 observational studies indexed under Acute Kidney Injury.

Browse Acute Kidney Injury studies →

Lead sponsor

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico is the lead sponsor of 214 studies on the registry; 71 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

The study population consists of all patients admitted to the reference hospital during the indicated time frame; in particular, all patients for whom sufficient data are available to establish the presence or absence of a diagnosis of AKI will be considered.

Inclusion criteria

  • Patients hospitalised from 01/01/2019 to 31/12/2023
  • Availability of a Hospital Discharge Form
  • At least one serum creatinine (sCr) determination available

Exclusion criteria

Exclusion Criteria:

  • Day-hospital admission
  • Discharge after an emergency room admission without hospital admission
  • Stage IV and V CKD
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
43,000 participants (estimated)
Patient registry
No

Groups and cohorts

  • Hospitalized Patients

    All patients hospitalized from 01/01/2019 to 12/31/2023.

06

What researchers measure

Primary outcomes

  1. Incidence of intra-hospital Acute Kidney Injury

    Time frame: From 01/01/2019 to 12/31/2023

Secondary outcomes

  1. Incidence of Acute Kidney Injury in different hospital wards

    Time frame: From 01/01/2019 to 12/31/2023

  2. Association between Acute Kidney Injury development and major discharge diagnoses

    Time frame: From 01/01/2019 to 12/31/2023

  3. Rate of re-hospitalisation in Acute Kidney Injury (AKI) and non-AKI patients

    Time frame: From 01/01/2019 to 12/31/2023

  4. Intra-hospital mortality rate in patients who developed AKI compared to those who did not

    Time frame: From 01/01/2019 to 12/31/2023

  5. Incidence of AKI associated with thrombotic microangiopathy

    Comparison between hospital discharge forms and presumptive diagnosis formulated by parametric algorithms based on haematochemical tests performed during hospitalisation

    Time frame: From 01/01/2019 to 12/31/2023

07

Study locations

1 site
  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
    Milan, 20122, Italy
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 27, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06697730
Lead sponsor
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Responsible party
Sponsor
First posted
Nov 20, 2024
Start date
Nov 25, 2025
Primary completion
Dec 2026 (estimated)
Completion
Dec 2027 (estimated)
Last update
Mar 27, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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