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CompletedNCT06695403Updated Jun 16, 2026

Telerehabilitation Versus Supervised Pilates Training in Lipedema Women

An interventional study of Pilates Exercise in Lipedema, sponsored by Cairo University. Completed at 1 site in Egypt. Open to female participants aged 35 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-06-16.

Sponsored by Cairo University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
60
Allocation
Not applicable
Ages
35 Years to 45 Years
Sex
Female
01

Study summary

  1. Pilates Exercise: The Pilates method is a low-intensity form of movement based on body control, which works the body in a complete way, promoting physical and mental health. PET is different when compared to traditional exercises, which, in turn, tend to isolate the working muscles and have specific training approaches using repetitive motions.
  2. Telerehabilitation: Telehealth is emerging as a key method for delivering essential healthcare. Primary care research suggests that telehealth is acceptable and has potential to overcome geographical barriers for individuals needing many times rehabilitation by eliminating the need for extensive and costly travel
  3. Diet approach: A customized low-carbohydrate high-fat (LCHF) restricted caloric diet in women with lipedema will be used for 12 weeks. The LCHF diet may be a valuable nutritional strategy for lipedema and overweight/obese women, reducing inflammatory status with a beneficial effect on weight, glucose profile the concentration of triglycerides and HDL
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Conditions studied

  • Lipedema

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03

In context

Lipedema

85 studies on the registry are indexed under Lipedema; 32 are open to participants now.

This study's enrollment of 60 is above the median of 35 across 42 interventional studies indexed under Lipedema.

Browse Lipedema studies →

Lead sponsor

Cairo University is the lead sponsor of 4,941 studies on the registry; 1,458 are open to participants now.

Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
35 Years to 45 Years
Sexes eligible
Female
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Sixty female patients diagnosed with lipedema.
  2. Their ages will range from 35-45 years old.
  3. Patients diagnosed with lipedema ≥ 5 years.
  4. Patients with grade 2 and 3 lipedema.
  5. Patients with type 2 and 3 lipedema.
  6. Patients with ≥ 25 kg/m2
  7. All patients will be clinically stable.

Exclusion criteria

Exclusion Criteria:

Patient with any of the following will be excluded from the study:

  1. Patients with lower limb edematous diseases such as lymphedema or chronic venous insufficiency.
  2. Patients with history of previous liposuction.
  3. Patients with asymmetrical lower limbs.
  4. Patients with history of bariatric surgeries.
  5. Patients on weight loss medications.
  6. Patients any medical condition prohibiting exercise (cardiac pacemakers, diabetes mellitus, uncontrolled hypertension, and congestive heart failure)
  7. Pregnant females.
  8. Patients with ≥ 40 kg/m2 (morbid obese).
  9. Cancer patients (patients on chemotherapy, immunotherapy radiopathy).
  10. Infectious diseases (/AIDS, , and Tuberculosis).
  11. Chronic inflammatory disease such as Sjogren's syndrome
  12. Patients with neurological disorders: stroke and epilepsy.
Terms in these criteria, in plain language(4)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

BMI (body mass index)

Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.

What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.

HIV

The human immunodeficiency virus, which weakens the immune system.

Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.

Hepatitis C tests

Hepatitis C is a virus that infects the liver. An HCV antibody test can stay positive after an infection has cleared (and is occasionally positive without one); an HCV RNA test shows whether the virus is there now.

After treatment, hepatitis C counts as cured when HCV RNA is still undetectable 12 weeks or more after the treatment ended. Studies often accept people cured this way.

Autoimmune disease

A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.

Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
60 participants (actual)

Study arms

  • Experimental
    Pilates Exercise (supervised versus telerehabilitation)

    1. Pilates Exercise: The Pilates method is a low-intensity form of movement based on body control, which works the body in a complete way, promoting physical and mental health. PET is different when compared to traditional exercises, which, in turn, tend to isolate the working muscles and have specific training approaches using repetitive motions. 2. Telerehabilitation: Telehealth is emerging as a key method for delivering essential healthcare. Primary care research suggests that telehealth is acceptable and has potential to overcome geographical barriers for individuals needing many times rehabilitation by eliminating the need for extensive and costly travel

    Procedure: Pilates Exercise

Interventions

  • ProcedurePilates Exercise

    1. Pilates Exercise: The Pilates method is a low-intensity form of movement based on body control, which works the body in a complete way, promoting physical and mental health. PET is different when compared to traditional exercises, which, in turn, tend to isolate the working muscles and have specific training approaches using repetitive motions. 2. Telerehabilitation: Telehealth is emerging as a key method for delivering essential healthcare. Primary care research suggests that telehealth is acceptable and has potential to overcome geographical barriers for individuals needing many times rehabilitation by eliminating the need for extensive and costly travel 3. Diet approach: A customized low-carbohydrate high-fat (LCHF) restricted caloric diet in women with lipedema will be used for 12 weeks. The LCHF diet may be a valuable nutritional strategy for lipedema and overweight/obese women, reducing inflammatory status with a beneficial effect on weight, glucose profile the concentration of

06

What researchers measure

Primary outcomes

  1. Six minutes walk test

    Procedures for the 6 minute walk test will be adopted from the American Thoracic Society (ATS) guidelines . 6 minute walk test is used to assess exercise tolerance

    Time frame: 12 weeks

Secondary outcomes

  1. World Health Organization's Quality of Life BREF questionnaire (QOL-BREF ).

    The World Health Organization (WHO) has defined quality of life as "an individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns". Recently, many general instruments have been used to measure QOL in different groups (e.g., patients, workers, population and so on). One of these instruments is the World Health Organization Quality of Life BREF questionnaire (WHOQOL-BREF) questionnaire which captures many subjective aspects of QOL

    Time frame: 12 weeks

  2. Limb Circumference

    Limb Circumference: These measurements of definite points diameter in lower extremities using tape measurement are also used to predict progression and as follow up instrument

    Time frame: 12 weeks

  3. Body mass index (MBI)

    Body mass index (MBI) is used as an indicator for weight reduction

    Time frame: 12 weeks

07

Study locations

1 site
  • Faculty of physical therapy
    Cairo, Egypt 3753450, Egypt
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References and documents

Individual participant data

Plan to share: Yes

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 16, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06695403
Lead sponsor
Cairo University
Responsible party
Safaa Salem Salem Shetawy (Assistant Lecturer of Physical Therapy, Cairo University) — Principal investigator
First posted
Nov 19, 2024
Start date
Nov 10, 2024
Primary completion
Mar 1, 2026
Completion
Mar 1, 2026
Last update
Jun 16, 2026

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jun 2024. You cannot join it, but the record below documents what was studied.

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