An interventional study of Postpartum NEST-Rural Program (Hospital based service model) in Health Care Utilization, sponsored by Wake Forest University Health Sciences. Recruiting at 1 site in United States. Open to female participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-28.
Sponsored by Wake Forest University Health Sciences · Not applicable, Interventional, and Health services research
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Among 133 studies in Patient Acceptance of Health Care with a site in United States — 23 open to participants now, 35 under way, 1 of them phase 3. Patient Acceptance of Health Care · United States.
Among the 133 studies in Patient Acceptance of Health Care with a site in United States, this one is the 18th largest by planned enrollment of the 108 interventional ones that give a count, is one of 13 that started in 2024, is one of 99 with no phase, reaches primary completion later than 27 of the 34 other live ones, and was the 120th registered.
308 studies on the registry are indexed under Patient Acceptance of Health Care; 53 are open to participants now.
Browse Patient Acceptance of Health Care studies →23 of the 133 studies in Patient Acceptance of Health Care with a site in United States are open now. Recruiting first, the newest first:
VA Office of Research and Development · Sites in United States
Ages 18+
Northwestern University · Sites in United States
Healthy volunteers
Cedars-Sinai Medical Center · Sites in United States
Ages 18–99
Andrea Wallace · Sites in United States
Ages 18+ · Healthy volunteers
North Carolina State University · Sites in United States
Ages 8–64 · Healthy volunteers
A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →
Of the 34 Patient Acceptance of Health Care studies recruiting now, 22 (65%) set no upper age limit and 9 (26%) stop at 75 or younger; 11 take children under 18; 16 take healthy volunteers.
This study: 18 Years and older · female · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
133 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 1 · Phase 2 2 · Phase 3 5 · Phase 4 2
First in 1998; this study’s year is marked. 13 started in 2024.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 1,300 is above the median of 201 across 217 interventional studies indexed under Patient Acceptance of Health Care.
Median enrollment 262 across the 108 interventional studies, 646 across the 24 observational. Of the 90 that completed or were terminated, 34 (38%) have results posted.
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2 of 133 have an industry lead sponsor. The 10 most frequent:
Wake Forest University Health Sciences is the lead sponsor of 1,351 studies on the registry; 200 are open to participants now.
Of its 332 completed or terminated interventional studies of FDA-regulated products, 251 (76%) have results posted.
Wake Forest University Health Sciences has 1 study filed under Patient Acceptance of Health Care — fewer than ten, so there is no comparison to draw.
13 of the studies in Patient Acceptance of Health Care with a site in United States that are under way reach primary completion within a year, 1 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07217145Phase 3University of UtahPREVENT HPV -Related Cancers Trial | 2026-11 |
| NCT05558332University of California, IrvineYouth Nominated Support Team | 2026-11 |
| NCT05605054Victoria D. OjedaUCSD RELINK: Connecting Adults To Supportive Services | 2026-12-31 |
| NCT06019377Portland State UniversityIntervention to Enhance Coping and Help-seeking Among Youth in Foster Care | 2026-12-31 |
| NCT07542769Northwestern UniversityChoice and Autonomy in Learning Mindfulness for Pediatric Residents | 2026-12-31 |
Add all 13 to your calendar (.ics) → With an account.
Among the 133 studies in Patient Acceptance of Health Care with a site in United States, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This study was designed to evaluate the implementation of the Nurse Education and Support Team (NEST) Program for postpartum women who reside in 5 rural counties in North Carolina. Overarching Hypothesis: Mothers and infants residing in rural communities, randomized to the NEST-Rural care model over the 3-year course of the project will: 1. Receive more coordinated care for addressing social, mental and physical health needs. 2. Experience fewer postpartum hospital readmissions and decreased utilization of emergency departments (ED) for healthcare. 3. Experience higher adherence to American College of Obstetricians and Gynecologists (ACOG) and American Academy of Pediatrics (AAP) guidelines for preventive care, including recently updated ongoing postpartum care, serial well-child visits and vaccinations compared to those assigned to usual care. This group will be compared to those assigned to usual care,
This is a Randomized Control Trial (RCT) designed study evaluating the implementation of the Nurse Education and Support Team (NEST) Program for postpartum women who reside in 5 rural counties (Davie, Davidson, Yadkin, Wilkes and Stokes counties) in North Carolina. The study cohort will be for all mothers residing in these rural counties and delivering their infant(s) in the Atrium Health Wake Forest Baptist Birth Center. It is anticipated that 1,300 mother-infant dyads will be enrolled and randomized to either usual care [visit 4-6 weeks postpartum] (\~650) or NEST-Rural care (\~650).
The NEST model is unique in that it supports both maternal and infant health, with an emphasis on using strategies aligned with evidence-based guidelines for postpartum and infant healthcare. Another important feature of NEST is integration of service delivery in the healthcare system. This integration facilitates reaching mother-infant dyads and bi-directional communication with the mother's and infant's healthcare providers to enable appropriate, timely healthcare. For example, as part of NEST, mothers are discharged from the hospital with a remote blood pressure monitor. Blood pressures are transmitted to a service hub through an app that is downloaded onto her phone prior to hospital discharge. The hub alerts the healthcare team, which follows-up with her to determine appropriate care.
Randomization to NEST-Rural services will include 3-5 nurse encounters with mothers and their infants in the postpartum period, postpartum remote blood pressure monitoring, breastfeeding support, infant weight checks, linking mothers and infants to needed social, behavioral, and health-related resources, and integration of service delivery with healthcare providers. Services will initiate in the postpartum hospital unit, with a NEST Coordinator introducing the program and identifying and making referrals and/or providing resources for emergent needs (e.g. pack-n-play, diapers), and offering and scheduling a follow-up nurse visit (home or telehealth-based, depending on needs) 2-3 weeks postpartum. Up to two additional nurse and/or social worker home/virtual visits will be provided, depending on the family's needs. At six weeks postpartum, the NEST Coordinator will contact the family to inquire whether any referrals were made and assess for continuing gaps in support. Following nurse encounters, a note will be sent to the mother's and infant's healthcare providers. If acute concerns are identified, the nurse will contact the provider immediately for additional care.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Postpartum women randomized to this group will receive the usual postpartum care from an Obstetrics provider and the following NEST-Rural Program: * Information about services and resources available in your community * A blood pressure monitor. * Access to the Babyscripts smartphone app. * A nurse visit(s) at home or via telehealth. * A visit(s) from a Family Outreach Specialist, if needed. * A follow-up phone call from a Coordinator in about 6 weeks
Other: Postpartum NEST-Rural Program (Hospital based service model)
Postpartum women randomized to this group will receive the usual postpartum care from an Obstetrics provider and the following: * Information about services and resources available in your community * A follow-up phone call from a Coordinator in about 6 weeks
NEST-Rural services will include 3-5 nurse encounters and, if indicated, up to 3 social work encounters with mothers and their infants in the postpartum period, postpartum remote blood pressure monitoring, breastfeeding support, infant weight checks, linking mothers and infants to needed social, behavioral, and health-related resources, and integration of service delivery with healthcare providers.
Median number of hospital readmissions - Maternal
Number of hospital readmissions in the 4th trimester
Time frame: Baseline through 30 days postpartum
Median number of hospital readmissions - Maternal
Number of hospital readmissions in the 4th trimester
Time frame: Baseline through 90 days postpartum
Median number of encounters for urgent or emergent care - Maternal
Number of visits to Urgent Care or the Emergency Room in the 4th trimester
Time frame: Baseline through 30 days postpartum
Median number of encounters for urgent or emergent care - Maternal
To determine number of visits to Urgent Care or the Emergency Room in the 4th trimester
Time frame: Baseline through 90 days postpartum
Proportion of women that attend recommended postpartum visits
Percentage of women that attended recommended visits to their obstetrician after delivery.
Time frame: Baseline through 90 days postpartum
Median number of hospital readmissions - Infant
Number of hospital readmissions after birth following hospital discharge.
Time frame: Baseline through 30 days postpartum
Median number of hospital readmissions - Infant
Number of hospital readmissions after birth following hospital discharge.
Time frame: Baseline through 90 days postpartum
Median number of encounters for urgent or emergent care - Infant
Number of visits to Urgent Care or the Emergency Room following hospital discharge.
Time frame: Baseline through 30 days postpartum
Median number of encounters for urgent or emergent care - Infant
Number of visits to Urgent Care or the Emergency Room following hospital discharge.
Time frame: Baseline through 90 days postpartum
Proportion of infants receiving a visit with an ambulatory care provider
Percentage of infants that attended recommended visits to their pediatric care provider within 21 days following hospital discharge
Time frame: Baseline through 21 days postpartum
Proportion of infants that received >/= 4 well-child care visits with an ambulatory care provider
Percentage of infants that attended recommended visits to their pediatric care provider within the first 9 months following hospital discharge
Time frame: Baseline through 274 days postpartum
Median number of days with >/= 1 remote blood pressure obtained - Maternal
Number of days that patients checked and remotely reported their blood pressure readings following hospital discharge.
Time frame: Baseline through 21 days postpartum
Proportion of women with a diagnosis of hypertensive disorders of pregnancy with at least one blood pressure obtained
Percentage of women diagnosed with hypertensive disorders that checked and remotely reported at least one blood pressure reading.
Time frame: Baseline through 10 days postpartum
Proportion of women with preeclampsia with severe features with at least one blood pressure obtained
Percentage of women with preeclampsia with severe features checked and remotely reported at least one blood pressure reading.
Time frame: Baseline through 3 days postpartum
Proportion of women exceeding 3 days length of stay in hospital after delivery
Percentage of women that remain hospitalized for more than 3 days following delivery.
Time frame: Baseline through date of hospital discharge
Median length of stay for hospital readmissions after delivery
Number of days mothers are readmitted and remain hospitalized after delivery.
Time frame: Baseline through 90 days postpartum
Proportion of women that attend a follow-up encounter with their primary care physician
Percentage of women that have a follow-up visit with their primary care physician within the first year after giving birth.
Time frame: Baseline through 365 days postpartum
Proportion of women who receive a nurse home visit
Percentage of women who receive a nurse home visit within 30 days of discharge
Time frame: Baseline through 30 days postpartum
Proportion of women eligible for an in-person home visit that received the in-person nurse visit
Percentage of women eligible for an in-person nurse home visit that received the in-person home visit.
Time frame: Baseline through 30 days postpartum
Proportion of women eligible for an in-person social work home visit that received the in-person social work visit
Percentage of women eligible for an in-person social work home visit that received the in-person social work visit
Time frame: Baseline through 45 days postpartum
Median number of hospital readmissions - Maternal
Number of hospital readmissions within the first 2 years following delivery
Time frame: Baseline through 365 days postpartum
Median number of hospital readmissions - Maternal
Number of hospital readmissions within the first 2 years following delivery
Time frame: Baseline through 730 days postpartum
Proportion of women scheduled for a mood check provider visit who received a mood check provider visit
Number of women scheduled for a mood check visit and attended their mood check visit within 21 days of discharge after delivery
Time frame: Baseline through 21 days postpartum
Proportion of infants that received recommended immunizations
Percentage of infants that received 3 hepatitis B, 2-3 rotavirus (depending on which one is given), 3 diphtheria/tetanus/pertussis, 3 haemophilus influenzae type B, 3 pneumococcal conjugate vaccines, 3 inactivated polio, and 1 flu vaccine within the first 9 months after discharge
Time frame: Baseline through Day 274
Proportion of infants exclusively receiving breastmilk at nurse encounter
Percentage of infants exclusively breastfeeding at the time of the nurse home visit within the first 3 weeks after discharge.
Time frame: Baseline through Day 21
Proportion of infants receiving any amount of breastmilk at nurse encounter
Percentage of infants receiving any breastmilk at the time of the nurse home visit within the first 3 weeks after discharge
Time frame: Baseline through Day 21
Median number of hospital readmissions - Infant
Number of hospital readmissions within the first 2 years following discharge.
Time frame: Baseline through day 365
Median number of hospital readmissions - Infant
Number of hospital readmissions within the first 2 years following discharge.
Time frame: Baseline through day 730
Plan to share: No
No publications or documents are linked to this record.
Started Dec 2024 (actual). Primary completion is estimated for Oct 2027, 34 months after the start.
Of 151 non-industry interventional studies with no phase under Patient Acceptance of Health Care, half reached primary completion within 19 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 35. This study's planned 34 months is above that.
Counting every sponsor, half of 154 studies reached it within 19 months; a quarter within 8 and three quarters within 34.
Since we started tracking on Sep 25, 2026, the dates moved once, on Sep 28, 2026: primary completion Jun 2027 → Oct 2027 and completion Dec 2029 → Oct 2029.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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