An interventional study of Infrabony defects will be filled with a volume-stable collagen matrix (VCMX) and Infrabony defects will be filled treated with a deproteinized bovine bone mineral with 10% collagen in Periodontal Diseases, sponsored by University of Bern. Recruiting at 1 site in Switzerland. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-10-06.
Sponsored by University of Bern · Not applicable, Interventional, and Treatment
To compare the healing of intrabony periodontal defects treated with either open flap debridement and a volume-stable collagen matrix (VCMX) or a deproteinized bovine bone mineral with 10% collagen. The results will shed light on the clinical potential of VCMX in regenerative periodontal surgery and help to develop new treatment strategies.
830 studies on the registry are indexed under Periodontal Diseases; 188 are open to participants now.
This study's planned enrollment of 80 is above the median of 45 across 530 interventional studies indexed under Periodontal Diseases.
Browse Periodontal Diseases studies →University of Bern is the lead sponsor of 207 studies on the registry; 47 are open to participants now.
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Inclusion Criteria
The periodontal infrabony defect will be opened by a papilla preservation flap, the root surface will be thoroughly cleaned with hand instruments and ultrasonic scalers, then the bony defect will be filled with a volume-stable collagen matrix (VCMX) only.
Device: Infrabony defects will be filled with a volume-stable collagen matrix (VCMX)
The periodontal infrabony defect will be opened by a flap, the root surface will be thoroughly cleaned with hand instruments and ultrasonic scalers, then the bony defect will be filled with deproteinized bovine bone mineral with 10% collagen.
Device: Infrabony defects will be filled treated with a deproteinized bovine bone mineral with 10% collagen
Infrabony defects will be filled with a volume-stable collagen matrix
Also known as: VCMX
Infrabony defects will be filled with with a deproteinized bovine bone mineral with 10% collagen
Also known as: DBBM
Clinical attachment level (CAL) change
Clinical attachment level (CAL) change in mm: the distance from the cemento-enamel junction to the bottom of the clinical periodontal pocket is being measured
Time frame: 12 months
Microbiological analysis
Quantification of the concentration of host-derived biomarkers (interleukin-1beta (IL-1b), IL-10, matrix-metalloproteinase- 8(MMP-8)) and periodontal bacterial species by means of gingival crevicular fluid and the biofilm sampling
Time frame: 1, 3, 12 weeks
Bleeding on probing (BoP)
Assessment of number of bleeding spots (percentage 0-100%) upon gentle probing of PPD at each test and control tooth site
Time frame: Baseline, 12 months
Pocket probing depth (PPD)
With a periodontal probe with mm markings, the distance between the gingival margin and the bottom of the pocket will be measured
Time frame: Baseline, 12 months
Plan to share: No
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