An interventional study of Periodontal Indices in Peridontal Disease and Aging, sponsored by Istanbul Medipol University Hospital. Completed at 1 site in Turkey. Open to participants aged 26 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-10-10.
Sponsored by Istanbul Medipol University Hospital · Not applicable, Interventional, and Diagnostic
Aging leads to a decline in physiological functions and increases the risk of chronic diseases. Periodontitis is a chronic inflammatory disease that causes progressive destruction of the tissues supporting the teeth. Taurine, an amino acid with anti-inflammatory and antioxidant effects, might impact both periodontitis and aging. This study investigated taurine, SIRT1, and TNF-α levels in saliva and blood of 66 healthy people in different age groups, with or without periodontal disease. The findings showed that young people with healthy periodontal status had higher levels of taurine and SIRT1 compared to others. TNF-α, a marker of inflammation, was linked to the severity of periodontitis and may help identifying it in younger individuals. Overall, higher TNF-α levels are associated with periodontal inflammation, while taurine levels decrease with age-related inflammation.
1,635 studies on the registry are indexed under Periodontitis; 327 are open to participants now.
This study's enrollment of 66 is above the median of 45 across 1,191 interventional studies indexed under Periodontitis.
Browse Periodontitis studies →Istanbul Medipol University Hospital is the lead sponsor of 350 studies on the registry; 58 are open to participants now.
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Exclusion Criteria:
Diagnostic Test: Periodontal Indices
Diagnostic Test: Periodontal Indices
Diagnostic Test: Periodontal Indices
Diagnostic Test: Periodontal Indices
Saliva, serum and periodontal indexes were obtained from patients
Also known as: Salivary Flow Rate, TNF-α Levels, SIRT1 Levels, Taurine Levels
Taurine
Taurine levels in saliva and serum were measured
Time frame: 12 Weeks
SIRT1
SIRT1 levels in saliva and serum were measured
Time frame: 12 Weeks
TNF-α
TNF-α levels in saliva and serum were measured
Time frame: 12 Weeks
Plan to share: No — Due to patients data privacy
No publications or documents are linked to this record.
This study is completed, as verified in Oct 2024. You cannot join it, but the record below documents what was studied.
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Istanbul Medipol University Hospital