CClinicalTrials.gg
Enrolling by invitationNCT06610240Peri-RUpdated Nov 13, 2024

Perioperative Treatment Outcomes of Early NSCLC

An observational study in NSCLC, sponsored by Shanghai Chest Hospital. Enrolling by invitation at 1 site in China. Per ClinicalTrials.gov, last updated 2024-11-13.

Sponsored by Shanghai Chest Hospital · Observational

From the registry’s dates

  • Primary completion was expected by May 2025, 1 year 4 months ago, but the record still lists the study as enrolling by invitation.
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
500
Sex
All
01

Study summary

This is an observational study evaluating the clinical characteristics, treatment patterns, and clinical outcomes of perioperative NSCLC patients receiving different treatment strategies. According to the inclusion and exclusion criteria, perioperative NSCLC patients admitted to the study center from January 1, 2020, to one year after the study initiation will be retrospectively screened and collected.

02

Conditions studied

  • NSCLC

Keywords

  • NSCLC;
  • perioperative treatment
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In context

Lead sponsor

Shanghai Chest Hospital is the lead sponsor of 194 studies on the registry; 94 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

stage I-III NSCLC under different perioperative treatment

Inclusion criteria

  • Stage I-III NSCLC patients confirmed by histological or cytological examination based on the 8th edition of the AJCC staging system.
  • Patients who have undergone radical lung cancer surgery.
  • Patients who have received neoadjuvant treatment before radical lung cancer surgery, including chemotherapy, targeted therapy, or immunotherapy both alone or combined.

Exclusion criteria

Exclusion Criteria:

  • Patients with other previous malignancies, except those who achieved complete remission at least two years before radical lung cancer surgery and did not require additional treatment.
  • Patients with incomplete key baseline and treatment information,including clinical stage, pathological type, neoadjuvant treatment, pathological response, imaging response after neoadjuvant.
  • Patients included in anti-tumor drug intervention or unblinded clinical trials, in which the treatment being administered is unknown.
  • Prior surgery, radiotherapy or systemic therapy for NSCLC, including radiofrequency ablation, etc.
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
500 participants (estimated)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. event-free survival

    the time from randomization to any progression of disease precluding surgery, progression or recurrence of disease after surgery, progression of disease in the absence of surgery, or death from any cause;

    Time frame: From date of diagnosis until the date of first documented progression, recurrence or date of death from any cause, whichever came first, assessed up to 36 months

  2. overall survival

    from diagnosis to death

    Time frame: From date of diagnosis until the date of death from any cause, whichever came first, assessed up to 60 months

Secondary outcomes

  1. R0 resection rate

    margin negative resection

    Time frame: usually 1 week after surgery

  2. major pathological response

    viable tumor cell less than 10%

    Time frame: usually 1 week after surgery

  3. p-CR

    no viable tumor cells was observed

    Time frame: usually 1 week after surgery

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Study locations

1 site
  • Zhong Hua
    Shanghai, Shanghai 200030, China
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References and documents

Individual participant data

Plan to share: Undecided — we need to further analyze the data

No publications or documents are linked to this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 13, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06610240
Lead sponsor
Shanghai Chest Hospital
Responsible party
Hua Zhong (professor, Shanghai Chest Hospital) — Principal investigator
First posted
Sep 24, 2024
Start date
Nov 1, 2024
Primary completion
May 31, 2025 (estimated)
Completion
Oct 31, 2025 (estimated)
Last update
Nov 13, 2024

Study contacts

Zhong Dr., MD
study chair · Shanghai Chest Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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No contact was published for this record. The registry link below has the sponsor’s details.

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