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RecruitingNCT06571552APHERCOAGUpdated Oct 20, 2026

Coagulation Disorders Secondary to Two Plasmapheresis Techniques (Double Filtration Plasmapheresis vs. PFS). Descriptive Pilot Study.

An interventional study of Single Plasma Exchange followed by Double Filtration Plasmapheresis in Hyperfibrinogenemia and Hemostatic Disorder, sponsored by Centre Hospitalier Universitaire de Nīmes. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-20.

Sponsored by Centre Hospitalier Universitaire de Nīmes · Not applicable, Interventional, and Health services research

From the registry’s dates

  • Started Dec 2024; still recruiting 1 year 10 months later.
Updated Oct 20, 2026Primary completion movedStudy completion moved+2 moreGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
6
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

Therapeutic plasmapheresis causes changes in haemostasis by purifying many of the circulating factors involved. Few reliable data are available on these changes and most studies are limited to coagulation factor assays before and after the session, with little data documenting the kinetics of regeneration of these factors. It is recognized that haemostasis disorders caused by therapeutic apheresis must be corrected in cases of active bleeding. However the methods of correcting these disorders are debatable. Finally, it is unclear when changes in haemostasis associated with coagulation factor deficiency should be corrected. Haemostasis is probably not based solely on the level of blood fibrinogen, but it is most often its threshold that is used to trigger replacement therapy to prevent a supposed risk of haemorrhage. No studies are available on the kinetics of haemostasis disorders and the risk of haemorrhage following a therapeutic plasmapheresis session, according to session type and fibrinogen level at the end of the session. The hypothesis of this research is that the link between fibrinogen level and thrombin generation capacity, post therapeutic plasmapheresis, will enable us to better assess the risk of haemorrhage and propose preventive measures.

Read the detailed description

Therapeutic plasmapheresis causes changes in haemostasis by purifying many of the circulating factors involved. Some data are available on changes in circulating haemostasis factors with the Single Plasma Exchange technique and the Double Filtration Plasmapheresis; however, most often these studies are carried out in specific clinical situations where other haemostasis disorders may be present, such as severe renal failure. Furthermore, in these studies, assessment of changes in haemostasis is often limited to coagulation factor assays before and after the session, with little data documenting the kinetics of regeneration of these factors, whose molecular weight and half-life vary widely. To date, there is no clear consensus/recommendation on the management of haemostasis disorders secondary to therapeutic apheresis. The need to correct haemostasis disorders caused by therapeutic apheresis also appears to be consensual in cases of active bleeding.The methods of correcting haemostasis disorders can also be discussed between infusion of coagulation factor and fresh frozen plasma. Finally, apart from these clinical situations, it is not clear when changes in haemostasis associated with coagulation factor deficiency should be corrected. There are no studies available on the kinetics of haemostasis disorders and the risk of haemorrhage following a therapeutic plasmapheresis session, depending on the type of session and the fibrinogen level at the end of the session. The hypothesis of our research is that the existence of a link between fibrinogen level and thrombin generation capacity, post therapeutic plasmapheresis, will enable us to better assess the risk of haemorrhage and to propose preventive measures.

02

Conditions studied

  • Hyperfibrinogenemia
  • Hemostatic Disorder

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Keywords

  • Double Filtration Plasmapheresis
  • Single Plasma Exchange
03

In context

Hemostatic Disorders

361 studies on the registry are indexed under Hemostatic Disorders; 65 are open to participants now.

This study's planned enrollment of 6 is below the median of 60 across 171 interventional studies indexed under Hemostatic Disorders.

Browse Hemostatic Disorders studies →

Lead sponsor

Centre Hospitalier Universitaire de Nīmes is the lead sponsor of 595 studies on the registry; 90 are open to participants now.

Browse Centre Hospitalier Universitaire de Nīmes studies →

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients without renal failure treated with chronic therapeutic plasmapheresis with a minimum treatment interval of 10 days and who can be treated with single plasma exchange (SPE) or double filtration plasmapheresis (DFPP) in accordance with the international recommendations.
  • Therapeutic plasmapheresis with regional citrate anticoagulation.
  • Patients over 18 years of age.
  • Patient affiliated to or benefiting from a social security scheme.
  • Free, informed and written consent, signed by the participant and the investigator (at the latest on the day of inclusion and before any examination required by the research).

Exclusion criteria

Exclusion Criteria:

  • Patients treated with oral anticoagulants or anti- agents.
  • Patients treated for hypercholesterolaemia or hypertriglyceridaemia; hyperviscosity, acquired haemophilia or nephrotic syndrome.
  • Indication for substitution with fresh frozen plasma (FFP) for the treatment of the disease.
  • Patient in an exclusion period determined by another study.
  • Patient under court protection, guardianship or curatorship.
  • Patient unable to give consent.
  • Patient for whom it is impossible to give informed information.
  • Pregnant or breast-feeding patients.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Platelets

Blood cells that help blood clot. Too few raises the risk of bleeding and bruising. A usual adult range is about 150–400 × 10⁹/L (150,000–400,000 per µL); each lab has its own reference range.

05

Study design

Phase
Not applicable
Primary purpose
Health services research
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
6 participants (estimated)

Study arms

  • Active comparator
    Patients benefitting from Single Plasma Exchange followed by Double Filtration Plasmapheresis

    For the patients in this group, the first cycle (T1) will consist of Single Plasma Exchange and the second cycle (T2) of Double Filtration Plasmapheresis.

    Procedure: Single Plasma Exchange followed by Double Filtration Plasmapheresis

  • Active comparator
    Patients benefitting from Double Filtration Plasmapheresis followed by Single Plasma Exchange

    For the patients in this group, the first cycle (T1) will consist of Double Filtration Plasmapheresis and the second cycle (T2) of Single Plasma Exchange.

    Procedure: Single Plasma Exchange followed by Double Filtration Plasmapheresis

Interventions

  • ProcedureSingle Plasma Exchange followed by Double Filtration Plasmapheresis

    Double Filtration Plasmapheresis followed by Single Plasma Exchange

06

What researchers measure

Primary outcomes

  1. Determination of fibrinogen levels before the first plasmapheresis session with single plasma exchange

    Clauss functional method, g/L

    Time frame: Day 0, before the session

  2. Determination of fibrinogen levels with Génésia® before the first plasmapheresis session with single plasma exchange

    Automated thrombin generation test on Génésia®.

    Time frame: Day 0, before the session

  3. Determination of fibrinogen levels after the first plasmapheresis session with single plasma exchange

    Clauss functional method, g/L

    Time frame: Day 0, end of session

  4. Determination of fibrinogen levels with Génésia® after the first plasmapheresis session with single plasma exchange

    Automated thrombin generation test on Génésia®.

    Time frame: Day 0, end of session

  5. Determination of fibrinogen levels after the plasmapheresis session with single plasma exchange

    Clauss functional method, g/L

    Time frame: Day 0, 1 hour after the session

  6. Determination of fibrinogen levels with Genesia® after the plasmapheresis session with single plasma exchange

    Automated thrombin generation test on Génésia®.

    Time frame: Day 0, 1 hour after the session

  7. Determination of fibrinogen levels after the plasmapheresis session with single plasma exchange

    Clauss functional method, g/L

    Time frame: Day 0, 4 hours after the session

  8. Determination of fibrinogen levels with Genesia® after the plasmapheresis session with single plasma exchange

    Automated thrombin generation test on Génésia®.

    Time frame: Day 0, 4 hours after the session

  9. Determination of fibrinogen levels before the plasmapheresis session with single plasma exchange

    Clauss functional method, g/L

    Time frame: Day 1

  10. Determination of fibrinogen levels with Genesia® before the plasmapheresis session with single plasma exchange

    Automated thrombin generation test on Génésia®.

    Time frame: Day 1

  11. Determination of fibrinogen levels before the plasmapheresis session with single plasma exchange

    Clauss functional method, g/L

    Time frame: Day 3

  12. Determination of fibrinogen levels with Genesia® before the plasmapheresis session with single plasma exchange

    Automated thrombin generation test on Génésia®.

    Time frame: Day 3

  13. Determination of fibrinogen levels after the plasmapheresis session with single plasma exchange

    Clauss functional method, g/L

    Time frame: Month 1, Day 1, 1 hour after the session

  14. Determination of fibrinogen levels with Genesia® after the plasmapheresis session with single plasma exchange

    Automated thrombin generation test on Génésia®.

    Time frame: Month 1, Day 1, 1 hour after the session

  15. Determination of fibrinogen levels after the plasmapheresis session with single plasma exchange

    Clauss functional method, g/L

    Time frame: Month 1, Day 4, 4 hours after the session

  16. Determination of fibrinogen levels with Genesia® after the plasmapheresis session with single plasma exchange

    Automated thrombin generation test on Génésia®.

    Time frame: Month 1, Day 4, 4 hours after the session

  17. Determination of fibrinogen levels after the plasmapheresis session with single plasma exchange

    Clauss functional method, g/L

    Time frame: Month 1, Day 3

  18. Determination of fibrinogen levels with Genesia® after the plasmapheresis session with single plasma exchange

    Automated thrombin generation test on Génésia®.

    Time frame: Month 1, Day 3

  19. Determination of fibrinogen levels before the first plasmapheresis session with double filtration plasmapheresis

    Clauss functional method, g/L

    Time frame: Day 0, before the session

  20. Determination of fibrinogen levels with Génésia® before the first plasmapheresis session with double filtration plasmapheresis

    Automated thrombin generation test on Génésia®.

    Time frame: Day 0, before the session

  21. Determination of fibrinogen levels after the first plasmapheresis session with double filtration plasmapheresis

    Clauss functional method, g/L

    Time frame: Day 0, end of session

  22. Determination of fibrinogen levels with Génésia® after the first plasmapheresis session with double filtration plasmapheresis

    Automated thrombin generation test on Génésia®.

    Time frame: Day 0, end of session

  23. Determination of fibrinogen levels after the first plasmapheresis session with double filtration plasmapheresis

    Clauss functional method, g/L

    Time frame: Day 0, 1 hour after the session

  24. Determination of fibrinogen levels with Génésia® after the first plasmapheresis session with double filtration plasmapheresis

    Automated thrombin generation test on Génésia®.

    Time frame: Day 0, 1 hour after the session

  25. Determination of fibrinogen levels after the first plasmapheresis session with double filtration plasmapheresis

    Clauss functional method, g/L

    Time frame: Day 0, 4 hours after the session

  26. Determination of fibrinogen levels with Génésia® after the first plasmapheresis session with double filtration plasmapheresis

    Automated thrombin generation test on Génésia®.

    Time frame: Day 0, 4 hours after the session

  27. Determination of fibrinogen levels before the plasmapheresis session with double filtration plasmapheresis

    Clauss functional method, g/L

    Time frame: Day 1

  28. Determination of fibrinogen levels with Génésia® before the plasmapheresis session with double filtration plasmapheresis

    Automated thrombin generation test on Génésia®.

    Time frame: Day 1

  29. Determination of fibrinogen levels before the plasmapheresis session with double filtration plasmapheresis

    Clauss functional method, g/L

    Time frame: Day 3

  30. Determination of fibrinogen levels with Génésia® before the plasmapheresis session with double filtration plasmapheresis

    Automated thrombin generation test on Génésia®.

    Time frame: Day 3

  31. Determination of fibrinogen levels after the plasmapheresis session with double filtration plasmapheresis

    Clauss functional method, g/L

    Time frame: Month 1, Day 1, 1 hour after the session

  32. Determination of fibrinogen levels with Génésia® after the plasmapheresis session with double filtration plasmapheresis

    Automated thrombin generation test on Génésia®.

    Time frame: Month 1, Day 1, 1 hour after the session

  33. Determination of fibrinogen levels after the plasmapheresis session with double filtration plasmapheresis

    Clauss functional method, g/L

    Time frame: Month 1, Day 1, 4 hours after the session

  34. Determination of fibrinogen levels with Génésia® after the plasmapheresis session with double filtration plasmapheresis

    Automated thrombin generation test on Génésia®.

    Time frame: Month 1, Day 1, 4 hours after the session

  35. Determination of fibrinogen levels after the plasmapheresis session with double filtration plasmapheresis

    Clauss functional method, g/L

    Time frame: Month 1, Day 3

  36. Determination of fibrinogen levels with Génésia® after the plasmapheresis session with double filtration plasmapheresis

    Automated thrombin generation test on Génésia®.

    Time frame: Month 1, Day 3

Secondary outcomes

  1. Complete blood count before the plasmapheresis session with single plasma exchange : White blood cells

    Quantitative, per microliter

    Time frame: Day 0, Hour 0

  2. Complete blood count after the plasmapheresis session with single plasma exchange : White blood cells

    Quantitative, per microliter

    Time frame: Day 0, Hour 1

  3. Complete blood count after the plasmapheresis session with single plasma exchange : White blood cells

    Quantitative, per microliter

    Time frame: Day 0, Hour 4

  4. Complete blood count after the plasmapheresis session with single plasma exchange : White blood cells

    Quantitative, per microliter

    Time frame: Day 1

  5. Complete blood count after the plasmapheresis session with single plasma exchange : White blood cells

    Quantitative, per microliter

    Time frame: Day 3

  6. Complete blood count before the plasmapheresis session with single plasma exchange : Red blood cells

    Quantitative, per microliter

    Time frame: Day 0, Hour 0

  7. Complete blood count after the plasmapheresis session with single plasma exchange : Red blood cells

    Quantitative, per microliter

    Time frame: Day 0, Hour 1

  8. Complete blood count after the plasmapheresis session with single plasma exchange : Red blood cells

    Quantitative, per microliter

    Time frame: Day 0, Hour 4

  9. Complete blood count after the plasmapheresis session with single plasma exchange : Red blood cells

    Quantitative, per microliter

    Time frame: Day 1

  10. Complete blood count after the plasmapheresis session with single plasma exchange : Red blood cells

    Quantitative, per microliter

    Time frame: Day 3

  11. Complete blood count before the plasmapheresis session with single plasma exchange : Hemoglobin

    Quantitative, grams per liter

    Time frame: Day 0, Hour 0

  12. Complete blood count after the plasmapheresis session with single plasma exchange : Hemoglobin

    Quantitative, grams per liter

    Time frame: Day 0, Hour 1

  13. Complete blood count after the plasmapheresis session with single plasma exchange : Hemoglobin

    Quantitative, grams per liter

    Time frame: Day 0, Hour 4

  14. Complete blood count after the plasmapheresis session with single plasma exchange : Hemoglobin

    Quantitative, grams per liter

    Time frame: Day 1

  15. Complete blood count after the plasmapheresis session with single plasma exchange : Hemoglobin

    Quantitative, grams per liter

    Time frame: Day 3

  16. Complete blood count before the plasmapheresis session with single plasma exchange : Platelets

    Quantitative, %

    Time frame: Day 0, Hour 0

  17. Complete blood count after the plasmapheresis session with single plasma exchange : Platelets

    Quantitative, %

    Time frame: Day 0, Hour 1

  18. Complete blood count after the plasmapheresis session with single plasma exchange : Platelets

    Quantitative, %

    Time frame: Day 0, Hour 4

  19. Complete blood count after the plasmapheresis session with single plasma exchange : Platelets

    Quantitative, %

    Time frame: Day 1

  20. Complete blood count after the plasmapheresis session with single plasma exchange : Platelets

    Quantitative, %

    Time frame: Day 3

  21. Complete blood count before the plasmapheresis session with single plasma exchange : Neutrophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 0

  22. Complete blood count after the plasmapheresis session with single plasma exchange : Neutrophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 1

  23. Complete blood count after the plasmapheresis session with single plasma exchange : Neutrophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 4

  24. Complete blood count after the plasmapheresis session with single plasma exchange : Neutrophils

    Quantitative, per microliter

    Time frame: Day 1

  25. Complete blood count after the plasmapheresis session with single plasma exchange : Neutrophils

    Quantitative, per microliter

    Time frame: Day 3

  26. Complete blood count before the plasmapheresis session with single plasma exchange : Lymphocytes

    Quantitative, per microliter

    Time frame: Day 0, Hour 0

  27. Complete blood count after the plasmapheresis session with single plasma exchange : Lymphocytes

    Quantitative, per microliter

    Time frame: Day 0, Hour 1

  28. Complete blood count after the plasmapheresis session with single plasma exchange : Lymphocytes

    Quantitative, per microliter

    Time frame: Day 0, Hour 4

  29. Complete blood count after the plasmapheresis session with single plasma exchange : Lymphocytes

    Quantitative, per microliter

    Time frame: Day 1

  30. Complete blood count after the plasmapheresis session with single plasma exchange : Lymphocytes

    Quantitative, per microliter

    Time frame: Day 3

  31. Complete blood count before the plasmapheresis session with single plasma exchange : Monocytes

    Quantitative, per microliter

    Time frame: Day 0, Hour 0

  32. Complete blood count after the plasmapheresis session with single plasma exchange : Monocytes

    Quantitative, per microliter

    Time frame: Day 0, Hour 1

  33. Complete blood count after the plasmapheresis session with single plasma exchange : Monocytes

    Quantitative, per microliter

    Time frame: Day 0, Hour 4

  34. Complete blood count after the plasmapheresis session with single plasma exchange : Monocytes

    Quantitative, per microliter

    Time frame: Day 1

  35. Complete blood count after the plasmapheresis session with single plasma exchange : Monocytes

    Quantitative, per microliter

    Time frame: Day 3

  36. Complete blood count before the plasmapheresis session with single plasma exchange : Eosinophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 0

  37. Complete blood count after the plasmapheresis session with single plasma exchange : Eosinophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 1

  38. Complete blood count after the plasmapheresis session with single plasma exchange : Eosinophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 4

  39. Complete blood count after the plasmapheresis session with single plasma exchange : Eosinophils

    Quantitative, per microliter

    Time frame: Day 1

  40. Complete blood count after the plasmapheresis session with single plasma exchange : Eosinophils

    Quantitative, per microliter

    Time frame: Day 3

  41. Complete blood count before the plasmapheresis session with single plasma exchange : Basophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 0

  42. Complete blood count after the plasmapheresis session with single plasma exchange : Basophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 1

  43. Complete blood count after the plasmapheresis session with single plasma exchange : Basophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 4

  44. Complete blood count after the plasmapheresis session with single plasma exchange : Basophils

    Quantitative, per microliter

    Time frame: Day 1

  45. Complete blood count after the plasmapheresis session with single plasma exchange : Basophils

    Quantitative, per microliter

    Time frame: Day 3

  46. Complete blood count before the plasmapheresis session with single plasma exchange : Hematocrit

    Quantitative, %

    Time frame: Day 0, Hour 0

  47. Complete blood count after the plasmapheresis session with single plasma exchange : Hematocrit

    Quantitative, %

    Time frame: Day 0, Hour 1

  48. Complete blood count after the plasmapheresis session with single plasma exchange : Hematocrit

    Quantitative, %

    Time frame: Day 0, Hour 4

  49. Complete blood count after the plasmapheresis session with single plasma exchange : Hematocrit

    Quantitative, %

    Time frame: Day 1

  50. Complete blood count after the plasmapheresis session with single plasma exchange : Hematocrit

    Quantitative, %

    Time frame: Day 3

  51. Complete blood count before the plasmapheresis session with single plasma exchange : Mean Corpuscular Volume

    Quantitative, %

    Time frame: Day 0, Hour 0

  52. Complete blood count after the plasmapheresis session with single plasma exchange : Mean Corpuscular Volume

    Quantitative, %

    Time frame: Day 0, Hour 1

  53. Complete blood count after the plasmapheresis session with single plasma exchange : Mean Corpuscular Volume

    Quantitative, %

    Time frame: Day 0, Hour 4

  54. Complete blood count after the plasmapheresis session with single plasma exchange : Mean Corpuscular Volume

    Quantitative, %

    Time frame: Day 1

  55. Complete blood count after the plasmapheresis session with single plasma exchange : Mean Corpuscular Volume

    Quantitative, %

    Time frame: Day 4

  56. Complete blood count before the plasmapheresis session with single plasma exchange : Mean Corpuscular Hemoglobin

    Quantitative, in pg

    Time frame: Day 0, Hour 0

  57. Complete blood count after the plasmapheresis session with single plasma exchange : Mean Corpuscular Hemoglobin

    Quantitative, in pg

    Time frame: Day 0, Hour 1

  58. Complete blood count after the plasmapheresis session with single plasma exchange : Mean Corpuscular Hemoglobin

    Quantitative, in pg

    Time frame: Day 0, Hour 4

  59. Complete blood count after the plasmapheresis session with single plasma exchange : Mean Corpuscular Hemoglobin

    Quantitative, in pg

    Time frame: Day 1

  60. Complete blood count after the plasmapheresis session with single plasma exchange : Mean Corpuscular Hemoglobin

    Quantitative, in pg

    Time frame: Day 3

  61. Complete blood count before the plasmapheresis session with single plasma exchange : Mean Corpuscular Hemoglobin Concentration

    Quantitative, in g/L

    Time frame: Day 0, Hour 0

  62. Complete blood count after the plasmapheresis session with single plasma exchange : Mean Corpuscular Hemoglobin Concentration

    Quantitative, in g/L

    Time frame: Day 0, Hour 1

  63. Complete blood count after the plasmapheresis session with single plasma exchange : Mean Corpuscular Hemoglobin Concentration

    Quantitative, in g/L

    Time frame: Day 0, Hour 4

  64. Complete blood count after the plasmapheresis session with single plasma exchange : Mean Corpuscular Hemoglobin Concentration

    Quantitative, in g/L

    Time frame: Day 1

  65. Complete blood count after the plasmapheresis session with single plasma exchange : Mean Corpuscular Hemoglobin Concentration

    Quantitative, in g/L

    Time frame: Day 3

  66. Serum albumin before the plasmapheresis session with single plasma exchange

    Quantitative, in g/dL

    Time frame: Day 0, Hour 0

  67. Serum albumin after the plasmapheresis session with single plasma exchange

    Quantitative, in g/dL

    Time frame: Day 0, Hour 1

  68. Serum albumin after the plasmapheresis session with single plasma exchange

    Quantitative, in g/dL

    Time frame: Day 0, Hour 4

  69. Serum albumin after the plasmapheresis session with single plasma exchange

    Quantitative, in g/dL

    Time frame: Day 1

  70. Serum albumin after the plasmapheresis session with single plasma exchange

    Quantitative, in g/dL

    Time frame: Day 3

  71. Prothrombin Time Test and International Normalized Ratio (PT/INR) before the plasmapheresis session with single plasma exchange

    In seconds

    Time frame: Day 0, Hour 0

  72. Prothrombin Time Test and International Normalized Ratio (PT/INR) after the plasmapheresis session with single plasma exchange

    In seconds

    Time frame: Day 0, Hour 1

  73. Prothrombin Time Test and International Normalized Ratio (PT/INR) after the plasmapheresis session with single plasma exchange

    In seconds

    Time frame: Day 0, Hour 4

  74. Prothrombin Time Test and International Normalized Ratio (PT/INR) after the plasmapheresis session with single plasma exchange

    In seconds

    Time frame: Day 1

  75. Prothrombin Time Test and International Normalized Ratio (PT/INR) after the plasmapheresis session with single plasma exchange

    In seconds

    Time frame: Day 3

  76. Factors VIII, IX, XI and XII before the plasmapheresis session with single plasma exchange

    By 1-stage APTT-based Factor assay, in seconds

    Time frame: Day 0, Hour 0

  77. Factors VIII, IX, XI and XII after the plasmapheresis session with single plasma exchange

    By 1-stage APTT-based Factor assay, in seconds

    Time frame: Day 0, Hour 1

  78. Factors VIII, IX, XI and XII after the plasmapheresis session with single plasma exchange

    By 1-stage APTT-based Factor assay, in seconds

    Time frame: Day 0, Hour 4

  79. Factors VIII, IX, XI and XII after the plasmapheresis session with single plasma exchange

    By 1-stage APTT-based Factor assay, in seconds

    Time frame: Day 1

  80. Factors VIII, IX, XI and XII after the plasmapheresis session with single plasma exchange

    By 1-stage APTT-based Factor assay, in seconds

    Time frame: Day 3

  81. Factors X, V and II [Prothrombin] before the plasmapheresis session with single plasma exchange

    Prothrombin assay, in seconds

    Time frame: Day 0, Hour 0

  82. Factors X, V and II [Prothrombin] after the plasmapheresis session with single plasma exchange

    Prothrombin assay, in seconds

    Time frame: Day 0, Hour 1

  83. Factors X, V and II [Prothrombin] after the plasmapheresis session with single plasma exchange

    Prothrombin assay, in seconds

    Time frame: Day 0, Hour 4

  84. Factors X, V and II [Prothrombin] after the plasmapheresis session with single plasma exchange

    Prothrombin assay, in seconds

    Time frame: Day 1

  85. Factors X, V and II [Prothrombin] after the plasmapheresis session with single plasma exchange

    Prothrombin assay, in seconds

    Time frame: Day 3

  86. D-dimers and circulating soluble fibrin monomers before the plasmapheresis session with single plasma exchange

    By enzyme-linked immunosorbent assay (ELISA) method

    Time frame: Day 0, Hour 0

  87. D-dimers and circulating soluble fibrin monomers after the plasmapheresis session with single plasma exchange

    By enzyme-linked immunosorbent assay (ELISA) method

    Time frame: Day 0, Hour 1

  88. D-dimers and circulating soluble fibrin monomers after the plasmapheresis session with single plasma exchange

    By enzyme-linked immunosorbent assay (ELISA) method

    Time frame: Day 0, Hour 4

  89. D-dimers and circulating soluble fibrin monomers after the plasmapheresis session with single plasma exchange

    By enzyme-linked immunosorbent assay (ELISA) method

    Time frame: Day 1

  90. D-dimers and circulating soluble fibrin monomers after the plasmapheresis session with single plasma exchange

    By enzyme-linked immunosorbent assay (ELISA) method

    Time frame: Day 3

  91. Platelet function test before the plasmapheresis session with single plasma exchange

    ADP/collagen and adrenalin/collagen cartridges.

    Time frame: Day 0, Hour 0

  92. Platelet function test after the plasmapheresis session with single plasma exchange

    ADP/collagen and adrenalin/collagen cartridges.

    Time frame: Day 0, Hour 1

  93. Platelet function test after the plasmapheresis session with single plasma exchange

    ADP/collagen and adrenalin/collagen cartridges.

    Time frame: Day 0, Hour 4

  94. Platelet function test after the plasmapheresis session with single plasma exchange

    ADP/collagen and adrenalin/collagen cartridges.

    Time frame: Day 1

  95. Platelet function test after the plasmapheresis session with single plasma exchange

    ADP/collagen and adrenalin/collagen cartridges.

    Time frame: Day 3

  96. von Willebrand factor (vWF) activity - ristocetin cofactor test before the plasmapheresis session with single plasma exchange

    Binding to platelet membrane glycoprotein Ib

    Time frame: Day 0, Hour 0

  97. von Willebrand factor (vWF) activity - ristocetin cofactor test after the plasmapheresis session with single plasma exchange

    Binding to platelet membrane glycoprotein Ib

    Time frame: Day 0, Hour 1

  98. von Willebrand factor (vWF) activity - ristocetin cofactor test after the plasmapheresis session with single plasma exchange

    Binding to platelet membrane glycoprotein Ib

    Time frame: Day 0, Hour 4

  99. von Willebrand factor (vWF) activity - ristocetin cofactor test after the plasmapheresis session with single plasma exchange

    Binding to platelet membrane glycoprotein Ib

    Time frame: Day 1

  100. von Willebrand factor (vWF) activity - ristocetin cofactor test after the plasmapheresis session with single plasma exchange

    Binding to platelet membrane glycoprotein Ib

    Time frame: Day 3

  101. Thrombin generation test on Génésia® before the plasmapheresis session with single plasma exchange (hemorrhagic exploration version)

    Triggered by 1 pM tissue factor

    Time frame: Day 0, Hour 0

  102. Thrombin generation test on Génésia® after the plasmapheresis session with single plasma exchange (hemorrhagic exploration version)

    Triggered by 1 pM tissue factor

    Time frame: Day 0, Hour 1

  103. Thrombin generation test on Génésia® after the plasmapheresis session with single plasma exchange (hemorrhagic exploration version)

    Triggered by 1 pM tissue factor

    Time frame: Day 0, Hour 4

  104. Thrombin generation test on Génésia® after the plasmapheresis session with single plasma exchange (hemorrhagic exploration version)

    Triggered by 1 pM tissue factor

    Time frame: Day 1

  105. Thrombin generation test on Génésia® after the plasmapheresis session with single plasma exchange (hemorrhagic exploration version)

    Triggered by 1 pM tissue factor

    Time frame: Day 3

  106. Automated thrombin generation test on Génésia® before the plasmapheresis session with single plasma exchange

    Triggered by 5 pM tissue factor with response to purified thrombomodulin (thrombotic exploration version)

    Time frame: Day 0, Hour 0

  107. Automated thrombin generation test on Génésia® after the plasmapheresis session with single plasma exchange

    Triggered by 5 pM tissue factor with response to purified thrombomodulin (thrombotic exploration version)

    Time frame: Day 0, Hour 1

  108. Automated thrombin generation test on Génésia® after the plasmapheresis session with single plasma exchange

    Triggered by 5 pM tissue factor with response to purified thrombomodulin (thrombotic exploration version)

    Time frame: Day 0, Hour 4

  109. Automated thrombin generation test on Génésia® after the plasmapheresis session with single plasma exchange

    Triggered by 5 pM tissue factor with response to purified thrombomodulin (thrombotic exploration version)

    Time frame: Day 1

  110. Automated thrombin generation test on Génésia® after the plasmapheresis session with single plasma exchange

    Triggered by 5 pM tissue factor with response to purified thrombomodulin (thrombotic exploration version)

    Time frame: Day 3

  111. Complete blood count before the double filtration plasmapheresis session : White blood cells

    Quantitative, per microliter

    Time frame: Day 0, Hour 0

  112. Complete blood count after the double filtration plasmapheresis session : White blood cells

    Quantitative, per microliter

    Time frame: Day 0, Hour 1

  113. Complete blood count after the double filtration plasmapheresis session : White blood cells

    Quantitative, per microliter

    Time frame: Day 0, Hour 4

  114. Complete blood count after the double filtration plasmapheresis session : White blood cells

    Quantitative, per microliter

    Time frame: Day 1

  115. Complete blood count after the double filtration plasmapheresis session : White blood cells

    Quantitative, per microliter

    Time frame: Day 3

  116. Complete blood count before the double filtration plasmapheresis session : Red blood cells

    Quantitative, per microliter

    Time frame: Day 0, Hour 0

  117. Complete blood count after the double filtration plasmapheresis session : Red blood cells

    Quantitative, per microliter

    Time frame: Day 0, Hour 1

  118. Complete blood count after the double filtration plasmapheresis session : Red blood cells

    Quantitative, per microliter

    Time frame: Day 0, Hour 4

  119. Complete blood count after the double filtration plasmapheresis session : Red blood cells

    Quantitative, per microliter

    Time frame: Day 1

  120. Complete blood count after the double filtration plasmapheresis session : Red blood cells

    Quantitative, per microliter

    Time frame: Day 4

  121. Complete blood count before the double filtration plasmapheresis session : Hemoglobin

    Quantitative, per microliter

    Time frame: Day 0, Hour 0

  122. Complete blood count after the double filtration plasmapheresis session : Hemoglobin

    Quantitative, per microliter

    Time frame: Day 0, Hour 1

  123. Complete blood count after the double filtration plasmapheresis session : Hemoglobin

    Quantitative, per microliter

    Time frame: Day 0, Hour 4

  124. Complete blood count after the double filtration plasmapheresis session : Hemoglobin

    Quantitative, per microliter

    Time frame: Day 1

  125. Complete blood count after the double filtration plasmapheresis session : Hemoglobin

    Quantitative, per microliter

    Time frame: Day 3

  126. Complete blood count before the double filtration plasmapheresis session : Platelets

    Quantitative, %

    Time frame: Day 0, Hour 0

  127. Complete blood count after the double filtration plasmapheresis session : Platelets

    Quantitative, %

    Time frame: Day 0, Hour 1

  128. Complete blood count after the double filtration plasmapheresis session : Platelets

    Quantitative, %

    Time frame: Day 0, Hour 4

  129. Complete blood count after the double filtration plasmapheresis session : Platelets

    Quantitative, %

    Time frame: Day 1

  130. Complete blood count after the double filtration plasmapheresis session : Platelets

    Quantitative, %

    Time frame: Day 3

  131. Complete blood count before the double filtration plasmapheresis session : Neutrophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 0

  132. Complete blood count after the double filtration plasmapheresis session : Neutrophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 1

  133. Complete blood count after the double filtration plasmapheresis session : Neutrophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 4

  134. Complete blood count after the double filtration plasmapheresis session : Neutrophils

    Quantitative, per microliter

    Time frame: Day 1

  135. Complete blood count after the double filtration plasmapheresis session : Neutrophils

    Quantitative, per microliter

    Time frame: Day 3

  136. Complete blood count before the double filtration plasmapheresis session : Lymphocytes

    Quantitative, per microliter

    Time frame: Day 0, Hour 0

  137. Complete blood count after the double filtration plasmapheresis session : Lymphocytes

    Quantitative, per microliter

    Time frame: Day 0, Hour 1

  138. Complete blood count after the double filtration plasmapheresis session : Lymphocytes

    Quantitative, per microliter

    Time frame: Day 0, Hour 4

  139. Complete blood count after the double filtration plasmapheresis session : Lymphocytes

    Quantitative, per microliter

    Time frame: Day 1

  140. Complete blood count after the double filtration plasmapheresis session : Lymphocytes

    Quantitative, per microliter

    Time frame: Day 3

  141. Complete blood count before the double filtration plasmapheresis session : Monocytes

    Quantitative, per microliter

    Time frame: Day 0, Hour 0

  142. Complete blood count after the double filtration plasmapheresis session : Monocytes

    Quantitative, per microliter

    Time frame: Day 0, Hour 1

  143. Complete blood count after the double filtration plasmapheresis session : Monocytes

    Quantitative, per microliter

    Time frame: Day 0, Hour 4

  144. Complete blood count after the double filtration plasmapheresis session : Monocytes

    Quantitative, per microliter

    Time frame: Day 1

  145. Complete blood count after the double filtration plasmapheresis session : Monocytes

    Quantitative, per microliter

    Time frame: Day 3

  146. Complete blood count before the double filtration plasmapheresis session : Eosinophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 0

  147. Complete blood count after the double filtration plasmapheresis session : Eosinophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 1

  148. Complete blood count after the double filtration plasmapheresis session : Eosinophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 4

  149. Complete blood count after the double filtration plasmapheresis session : Eosinophils

    Quantitative, per microliter

    Time frame: Day 1

  150. Complete blood count after the double filtration plasmapheresis session : Eosinophils

    Quantitative, per microliter

    Time frame: Day 3

  151. Complete blood count before the double filtration plasmapheresis session : Basophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 0

  152. Complete blood count after the double filtration plasmapheresis session : Basophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 1

  153. Complete blood count after the double filtration plasmapheresis session : Basophils

    Quantitative, per microliter

    Time frame: Day 0, Hour 4

  154. Complete blood count after the double filtration plasmapheresis session : Basophils

    Quantitative, per microliter

    Time frame: Day 1

  155. Complete blood count after the double filtration plasmapheresis session : Basophils

    Quantitative, per microliter

    Time frame: Day 3

  156. Complete blood count before the double filtration plasmapheresis session : Hematocrit

    Quantitative, %

    Time frame: Day 0, Hour 0

  157. Complete blood count after the double filtration plasmapheresis session : Hematocrit

    Quantitative, %

    Time frame: Day 0, Hour 1

  158. Complete blood count after the double filtration plasmapheresis session : Hematocrit

    Quantitative, %

    Time frame: Day 0, Hour 4

  159. Complete blood count after the double filtration plasmapheresis session : Hematocrit

    Quantitative, %

    Time frame: Day 1

  160. Complete blood count after the double filtration plasmapheresis session : Hematocrit

    Quantitative, %

    Time frame: Day 3

  161. Complete blood count before the double filtration plasmapheresis session : Mean Corpuscular Volume

    Quantitative, fL

    Time frame: Day 0, Hour 0

  162. Complete blood count after the double filtration plasmapheresis session : Mean Corpuscular Volume

    Quantitative, fL

    Time frame: Day 0, Hour 1

  163. Complete blood count after the double filtration plasmapheresis session : Mean Corpuscular Volume

    Quantitative, fL

    Time frame: Day 0, Hour 4

  164. Complete blood count after the double filtration plasmapheresis session : Mean Corpuscular Volume

    Quantitative, fL

    Time frame: Day 1

  165. Complete blood count after the double filtration plasmapheresis session : Mean Corpuscular Volume

    Quantitative, fL

    Time frame: Day 3

  166. Complete blood count before the double filtration plasmapheresis session : Mean Corpuscular Hemoglobin

    Quantitative, pg

    Time frame: Day 0, Hour 0

  167. Complete blood count after the double filtration plasmapheresis session : Mean Corpuscular Hemoglobin

    Quantitative, pg

    Time frame: Day 0, Hour 1

  168. Complete blood count after the double filtration plasmapheresis session : Mean Corpuscular Hemoglobin

    Quantitative, pg

    Time frame: Day 0, Hour 4

  169. Complete blood count after the double filtration plasmapheresis session : Mean Corpuscular Hemoglobin

    Quantitative, pg

    Time frame: Day 1

  170. Complete blood count after the double filtration plasmapheresis session : Mean Corpuscular Hemoglobin

    Quantitative, pg

    Time frame: Day 3

  171. Complete blood count before the double filtration plasmapheresis session : Mean Corpuscular Hemoglobin Concentration

    Quantitative, g/L

    Time frame: Day 0, Hour 0

  172. Complete blood count after the double filtration plasmapheresis session : Mean Corpuscular Hemoglobin Concentration

    Quantitative, g/L

    Time frame: Day 0, Hour 1

  173. Complete blood count after the double filtration plasmapheresis session : Mean Corpuscular Hemoglobin Concentration

    Quantitative, g/L

    Time frame: Day 0, Hour 4

  174. Complete blood count after the double filtration plasmapheresis session : Mean Corpuscular Hemoglobin Concentration

    Quantitative, g/L

    Time frame: Day 1

  175. Complete blood count after the double filtration plasmapheresis session : Mean Corpuscular Hemoglobin Concentration

    Quantitative, g/L

    Time frame: Day 3

  176. Serum albumin before the double filtration plasmapheresis session.

    Quantitative, g/L

    Time frame: Day 0, Hour 0

  177. Serum albumin after the double filtration plasmapheresis session.

    Quantitative, g/L

    Time frame: Day 0, Hour 1

  178. Serum albumin after the double filtration plasmapheresis session.

    Quantitative, g/L

    Time frame: Day 0, Hour 4

  179. Serum albumin after the double filtration plasmapheresis session.

    Quantitative, g/L

    Time frame: Day 1

  180. Serum albumin after the double filtration plasmapheresis session.

    Quantitative, g/L

    Time frame: Day 3

  181. Prothrombin Time Test and International Normalized Ratio (PT/INR) before the double filtration plasmapheresis session.

    In seconds

    Time frame: Day 0, Hour 0

  182. Prothrombin Time Test and International Normalized Ratio (PT/INR) after the double filtration plasmapheresis session.

    In seconds

    Time frame: Day 0, Hour 1

  183. Prothrombin Time Test and International Normalized Ratio (PT/INR) after the double filtration plasmapheresis session.

    In seconds

    Time frame: Day 0, Hour 4

  184. Prothrombin Time Test and International Normalized Ratio (PT/INR) after the double filtration plasmapheresis session.

    In seconds

    Time frame: Day 1

  185. Prothrombin Time Test and International Normalized Ratio (PT/INR) after the double filtration plasmapheresis session.

    In seconds

    Time frame: Day 3

  186. Factors VIII, IX, XI and XII before the double filtration plasmapheresis session.

    1-stage APTT-based Factor assay

    Time frame: Day 0, Hour 0

  187. Factors VIII, IX, XI and XII after the double filtration plasmapheresis session.

    1-stage APTT-based Factor assay

    Time frame: Day 0, Hour 1

  188. Factors VIII, IX, XI and XII after the double filtration plasmapheresis session.

    1-stage APTT-based Factor assay

    Time frame: Day 0, Hour 4

  189. Factors VIII, IX, XI and XII after the double filtration plasmapheresis session.

    1-stage APTT-based Factor assay

    Time frame: Day 1

  190. Factors VIII, IX, XI and XII after the double filtration plasmapheresis session.

    1-stage APTT-based Factor assay

    Time frame: Day 3

  191. Factors X, V and II [Prothrombin] before the double filtration plasmapheresis session.

    Prothrombin assay, in seconds

    Time frame: Day 0, Hour 0

  192. Factors X, V and II [Prothrombin] after the double filtration plasmapheresis session.

    Prothrombin assay, in seconds

    Time frame: Day 0, Hour 1

  193. Factors X, V and II [Prothrombin] after the double filtration plasmapheresis session.

    Prothrombin assay, in seconds

    Time frame: Day 0, Hour 4

  194. Factors X, V and II [Prothrombin] after the double filtration plasmapheresis session.

    Prothrombin assay, in seconds

    Time frame: Day 1

  195. Factors X, V and II [Prothrombin] after the double filtration plasmapheresis session.

    Prothrombin assay, in seconds

    Time frame: Day 3

  196. D-dimers and circulating soluble fibrin monomers before the double filtration plasmapheresis session.

    By enzyme-linked immunosorbent assay (ELISA) method

    Time frame: Day 0, Hour 0

  197. D-dimers and circulating soluble fibrin monomers after the double filtration plasmapheresis session.

    By enzyme-linked immunosorbent assay (ELISA) method

    Time frame: Day 0, Hour 1

  198. D-dimers and circulating soluble fibrin monomers after the double filtration plasmapheresis session.

    By enzyme-linked immunosorbent assay (ELISA) method

    Time frame: Day 0, Hour 4

  199. D-dimers and circulating soluble fibrin monomers after the double filtration plasmapheresis session.

    By enzyme-linked immunosorbent assay (ELISA) method

    Time frame: Day 1

  200. D-dimers and circulating soluble fibrin monomers after the double filtration plasmapheresis session.

    By enzyme-linked immunosorbent assay (ELISA) method

    Time frame: Day 3

  201. Platelet function test before the double filtration plasmapheresis session.

    ADP/collagen and adrenalin/collagen cartridges

    Time frame: Day 0, Hour 0

  202. Platelet function test after the double filtration plasmapheresis session.

    ADP/collagen and adrenalin/collagen cartridges

    Time frame: Day 0, Hour 1

  203. Platelet function test after the double filtration plasmapheresis session.

    ADP/collagen and adrenalin/collagen cartridges

    Time frame: Day 0, Hour 4

  204. Platelet function test after the double filtration plasmapheresis session.

    ADP/collagen and adrenalin/collagen cartridges

    Time frame: Day 1

  205. Platelet function test after the double filtration plasmapheresis session.

    ADP/collagen and adrenalin/collagen cartridges

    Time frame: Day 3

  206. von Willebrand factor (vWF) activity - ristocetin cofactor test before the double filtration plasmapheresis session.

    Binding to platelet membrane glycoprotein Ib

    Time frame: Day 0, Hour 0

  207. von Willebrand factor (vWF) activity - ristocetin cofactor test after the double filtration plasmapheresis session.

    Binding to platelet membrane glycoprotein Ib

    Time frame: Day 0, Hour 1

  208. von Willebrand factor (vWF) activity - ristocetin cofactor test after the double filtration plasmapheresis session.

    Binding to platelet membrane glycoprotein Ib

    Time frame: Day 0, Hour 4

  209. von Willebrand factor (vWF) activity - ristocetin cofactor test after the double filtration plasmapheresis session.

    Binding to platelet membrane glycoprotein Ib

    Time frame: Day 1

  210. von Willebrand factor (vWF) activity - ristocetin cofactor test after the double filtration plasmapheresis session.

    Binding to platelet membrane glycoprotein Ib

    Time frame: Day 3

  211. Automated thrombin generation test on Génésia® before the plasmapheresis session with single plasma exchange (hemorrhagic exploration version)

    Triggered by 1 pM tissue factor

    Time frame: Day 0, Hour 0

  212. Automated thrombin generation test on Génésia® after the plasmapheresis session with single plasma exchange (hemorrhagic exploration version)

    Triggered by 1 pM tissue factor

    Time frame: Day 0, Hour 1

  213. Automated thrombin generation test on Génésia® after the plasmapheresis session with single plasma exchange (hemorrhagic exploration version)

    Triggered by 1 pM tissue factor

    Time frame: Day 0, Hour 4

  214. Automated thrombin generation test on Génésia® after the plasmapheresis session with single plasma exchange (hemorrhagic exploration version)

    Triggered by 1 pM tissue factor

    Time frame: Day 1

  215. Automated thrombin generation test on Génésia® after the plasmapheresis session with single plasma exchange (hemorrhagic exploration version)

    Triggered by 1 pM tissue factor

    Time frame: Day 3

  216. Automated thrombin generation test on Génésia® before the plasmapheresis session with single plasma exchange (thrombotic exploration version)

    Triggered by 5 pM tissue factor with response to purified thrombomodulin

    Time frame: Day 0, Hour 0

  217. Automated thrombin generation test on Génésia® after the plasmapheresis session with single plasma exchange (thrombotic exploration version)

    Triggered by 5 pM tissue factor with response to purified thrombomodulin

    Time frame: Day 0, Hour 1

  218. Automated thrombin generation test on Génésia® after the plasmapheresis session with single plasma exchange (thrombotic exploration version)

    Triggered by 5 pM tissue factor with response to purified thrombomodulin

    Time frame: Day 0, Hour 4

  219. Automated thrombin generation test on Génésia® after the plasmapheresis session with single plasma exchange (thrombotic exploration version)

    Triggered by 5 pM tissue factor with response to purified thrombomodulin

    Time frame: Day 1

  220. Automated thrombin generation test on Génésia® after the plasmapheresis session with single plasma exchange (thrombotic exploration version)

    Triggered by 5 pM tissue factor with response to purified thrombomodulin

    Time frame: Day 3

  221. Plasma Bank

    Storage of unused tube ends

    Time frame: Before Day 0, hour 0

  222. Plasma Bank

    Storage of unused tube ends

    Time frame: Day 0, hour1

  223. Plasma Bank

    Storage of unused tube ends

    Time frame: Day 0, hour 4

  224. Plasma Bank

    Storage of unused tube ends

    Time frame: Day 1

  225. Plasma Bank

    Storage of unused tube ends

    Time frame: Day 3

  226. Plasma Bank

    Storage of unused tube ends

    Time frame: After end of session Day 0, H0

Other outcomes

  1. Gender of patients

    Recorded as Male, Female, Nonbinary

    Time frame: Day 0, Hour 0

  2. Age of patients

    Recorded in years

    Time frame: Day 0, Hour 0

  3. Weight of patients

    Recorded in kilos

    Time frame: Day 0, Hour 0

  4. Height of patients

    Recorded in centimeters

    Time frame: Day 0, Hour 0

  5. Diagnostic history of patients

    The patients' diagnostic history will be recorded

    Time frame: Day 0, Hour 0

  6. Patient's apheresis protocol

    The apheresis protocol used, and parameters related to plasmapheresis will be recorded

    Time frame: Day 0, Hour 0

07

Study locations

1 of 1 sites recruiting
08

Updates

1 registry update since Sep 25, 2026
Sites
1 site added, 1 site removed
Show site
  • CHU de Nîmes · Nîmes, France
Show 1 removed
  • CHU de Nîmes · Nîmes, France
Oct 20, 2026
Primary completion
Jun 2025→Dec 17, 2026
Oct 20, 2026
Study completion
Jun 2026→Feb 2, 2027
Oct 20, 2026
Show all 1 update
  1. Oct 20, 2026
    1 site added, 1 site removed
    Show site
    • CHU de Nîmes · Nîmes, France
    Show 1 removed
    • CHU de Nîmes · Nîmes, France
    Primary completion Jun 2025→Dec 17, 2026
    Study completion Jun 2026→Feb 2, 2027
    + 2 other changes: verification date and index terms

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

09

Registry details

Key details

Study ID
NCT06571552
Lead sponsor
Centre Hospitalier Universitaire de Nīmes
Responsible party
Sponsor
First posted
Aug 26, 2024
Start date
Dec 17, 2024
Primary completion
Dec 17, 2026 (estimated)
Completion
Feb 2, 2027 (estimated)
Last update
Oct 20, 2026

Study contacts

Olivier MORANNE, Professor
Contact
olivier.moranne@chu-nimes.fr
+334.66.68.31.49
Anissa MEGZARI
Contact
drc@chu-nimes.fr
+33466684236
Emilie PAMBRUN, Docteur
principal investigator · Nîmes University Hospital
Sylvie BOUVIER, Docteur
principal investigator · Nîmes University Hospital
Jean-Christophe GRIS, Professor
principal investigator · Nîmes University Hospital
Mathieu FORTIER
principal investigator · Nîmes University Hospital

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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