An interventional study of Micro-Western Array in Knee Osteoarthritis, sponsored by China Medical University Hospital. Recruiting at 1 site in Taiwan. Open to participants aged 50 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-08-14.
Sponsored by China Medical University Hospital · Not applicable, Interventional, and Basic science
In the previous study "Using omics technology to explore the mechanism of acupuncture treatment of different acupoints of knee osteoarthritis: a randomized controlled trial (CMUH109-REC3-113)", we found that acupuncture for knee osteoarthritis(KOA) significantly reduces inflammation, apoptosis, and metabolism-related serum protein profiles. However, due to the lack of serum protein data from the control group, it is impossible to establish standard values for comparison. To analyze the protein expression in the serum of KOA control group subjects, we also measured the spectral energy values of the radial artery pulse wave obtained from the pulse sphygmograph and the meridian energy values obtained from Ryodoraku. The results obtained can be compared with previous studies, thus this experiment was designed.
4,398 studies on the registry are indexed under Osteoarthritis; 582 are open to participants now.
This study's planned enrollment of 50 is below the median of 70 across 3,440 interventional studies indexed under Osteoarthritis.
Browse Osteoarthritis studies →China Medical University Hospital is the lead sponsor of 464 studies on the registry; 116 are open to participants now.
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Exclusion Criteria:
Monitoring the stability of protein expression, pulse wave and meridian energy in the serum of the KOA control group (participants without knee pain).
Device: Micro-Western Array
The subjects first took the energy measurement of the pulse sphygmograph and Ryodoraku, rested for 20 minutes, and then repeated the measurements again. In order to comply with the acupuncture treatment course was 5 weeks in the previous study, we have two blood draw point. Each subject's blood was drawn for the first time, and then for the second time in 5 weeks later. Each subject drew 10ml of blood each time. The blood samples are analyzed by Micro-Western Array (MWA) and Enzyme-linked immunosorbent assay (ELISA) to obtain the serum protein content value of healthy individuals.
Also known as: Enzyme-linked immunosorbent assay, pulse sphygmograph, Ryodoraku
Micro-Western Array and Enzyme-linked immunosorbent assay
Obtaining the serum protein content value
Time frame: the first and the fifth weeks
pulse sphygmograph and Ryodoraku
the energy measurement of pulse and meridians
Time frame: the first and the fifth weeks
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China Medical University Hospital