An observational study in Acute Respiratory Failure and Invasive Mechanical Ventilation, sponsored by Ankara University. Status unknown at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-07-31.
Sponsored by Ankara University · Observational
The study aims to research the values of mechanical power, driving pressure, and elastic power in predicting the duration of mechanical ventilation in critically ill patients undergoing invasive mechanical ventilation. This will help determine which patients may be considered for early extubation, which patients should wait for extubation, and the patients where extubation is anticipated to be prolonged, attention should be paid to initiating preparations for alternative treatment methods like tracheostomy early.
Due to acute respiratory failure, mechanical ventilation support is provided to over 20 million patients worldwide. Therefore, various studies are being conducted to prevent ventilation-associated lung injury in patients receiving invasive mechanical ventilation, especially in conditions such as acute respiratory distress syndrome (ARDS).
Initially, protective mechanical ventilation studies have shown that keeping plateau pressure (Pplat), reflecting static compliance, below 30 cmH2O along with low tidal volume reduces all-cause mortality. Subsequent studies have defined driving pressure as Pplato-PEEP, suggesting that keeping driving pressure below 15 cmH2O may reduce excessive strain on healthy lung tissue and the development of ventilator-associated lung injury.
In 2016, Gattinoni and colleagues defined mechanical power as the power applied by the ventilator to the entire respiratory system per minute during mechanical ventilation, prompting research into the relationship between mechanical power and mortality, particularly in ARDS.
Mechanical power consists of three components: energy delivered with each breath when PEEP is applied, energy applied to overcome airway resistance, and elastic energy delivered with each tidal breath.
Finally, Yongpeng Xie and colleagues hypothesized that elastic power, normalized by compliance, has a more significant relationship with mortality in ARDS patients. Studies on mechanical power, driving pressure, and elastic power typically focus on values measured on the first day of intubation and are predominantly conducted in ARDS patients.
By including all patients under invasive mechanical ventilation in the study, the importance of measuring and monitoring mechanical ventilator parameters (mechanical power, driving pressure, and elastic power) at 0th, 24th, and 48th hours to predict extubation within the first week is being determined. This aims to identify when early extubation should be considered, when extubation should be delayed, and to prepare for alternative treatment options like tracheostomy in cases where extubation might be prolonged.
1,675 studies on the registry are indexed under Respiratory Insufficiency; 300 are open to participants now.
This study's planned enrollment of 100 is close to the median of 100 across 556 observational studies indexed under Respiratory Insufficiency.
Browse Respiratory Insufficiency studies →Ankara University is the lead sponsor of 318 studies on the registry; 65 are open to participants now.
Counted across the registry records on this site, refreshed daily.
All patients who have recently been intubated for acute respiratory failure and admitted to participating ICUs will be screened and included in the study if eligible.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
extubation time
time patients will be extubated after intubation
Time frame: seven days
mortality
28 day mortality
Time frame: 28 days
acute renal failure
Number of patients who developed acute kidney injury according to KDIGO guidelines
Time frame: one month
ICU/ hospital length of stay
ICU/ hospital length of stay
Time frame: three months
Plan to share: Undecided
Started Apr 2024 (actual). Primary completion is estimated for Jan 2025, 9 months after the start.
Of 271 non-industry observational studies under Respiratory Insufficiency, half reached primary completion within 21 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 49. This study's planned 9 months is below that.
Counting every sponsor, half of 288 studies reached it within 21 months; a quarter within 11 and three quarters within 44.
How these figures are worked out, and which studies are left out of them.
This study is status unknown, as verified in Jul 2024. You cannot join it, but the record below documents what was studied.
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