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CompletedNCT06525233Updated Jul 29, 2024

Interval Aerobic Training and Continious Training

An observational study in Coronary Artery Disease and Exercise Addiction, sponsored by Istanbul Medipol University Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 40 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-07-29.

Sponsored by Istanbul Medipol University Hospital · Observational

Study type
Observational
Model
Case-crossover
Time perspective
Prospective
Enrollment
40
Ages
40 Years to 80 Years
Sex
All
01

Study summary

This research is comparing the effects of interval and continuous training which are the two types of aerobic training on persons' life quality and exercise capacity on coronary artery disease patients.

Read the detailed description

The participants are diagnosed coronary artery disease aged between 40- 80 and have no mental and physical disability to take part in research. The participants' demographic infos and clinical story were recorded. To evaluate exercise capacity we used the symptom-limited exercise test (ETT) and six minute walking test (6DYT). We evaluate the life quality by using Short Form-36 (SF-36).

All those evaluation tests are done before and after training. Participants are randomly divided into two groups, the first group took part in interval aerobic training (AAE) while the other group was joining in continuous training (SAE) three times a week during 6 weeks. In both groups, significant changes were found in ETT, test time and 6 DYT scores after the rehabilitation program (p\<0,05). But only AAE group have important statistical values comparing to SAE group on test time and 6DYT scores. After training SAE group showed significant statistical change in every SF-36 parameter, while AAE group showing significant values except energy/fatigue. AAE group have statistically significant changes comparing to SAE group on that parameters; physical function, role limitations due to physical function, role limitations due to emotional function and general health (p\<0,05). Consequently AAE is much more tolerable comparing to SAE and AAE is considered more effective in increasing some parameters. On the other hand, we observed that both training types can be used in cardiac rehabilitation safely.

02

Conditions studied

  • Coronary Artery Disease
  • Exercise Addiction

Keywords

  • continious training
  • interval training
03

In context

Coronary Artery Disease

5,676 studies on the registry are indexed under Coronary Artery Disease; 958 are open to participants now.

This study's enrollment of 40 is below the median of 335 across 1,978 observational studies indexed under Coronary Artery Disease.

Browse Coronary Artery Disease studies →

Lead sponsor

Istanbul Medipol University Hospital is the lead sponsor of 365 studies on the registry; 59 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
40 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Name-Surname, age, sex, body-weight index, educational status, married/single/divorced, job and clinical background (If has any surgery and myocardial infarction)

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • diagnosed coronary artery disease
  • aged between 40-80
  • over %55 ejection fraction

Exclusion criteria

Exclusion Criteria:

  • mental and physical disability
  • unstable angina pectoris
  • thrombophlebitis
05

Study design

Observational model
Case-crossover
Time perspective
Prospective
Enrollment
40 participants (actual)
Target follow-up
6 Weeks
Patient registry
Yes

Groups and cohorts

  • Treatment

    humans that diagnosed as coronary artery disease, joined two aerobic exercise groups. One of this group includes interval exercise and the other one includes continuous exercise.

    Other: Physiotherapy and rehabilitation

Interventions

  • OtherPhysiotherapy and rehabilitation

    The aerobic exercise is very crucial part of cardiac rehabilitation. This study compares the effects of interval and continuous training which are the two types of aerobic training on persons' life quality and exercise capacity diagnosed coronary artery disease patients.

06

What researchers measure

Primary outcomes

  1. the effect of intermittent and continuous aerobic exercise on exercise capacity

    we used the symptom-limited exercise test and six minute walking test (6DYT). All evaluation tests are done before and after training. Participants were into randomised two groups: interval aerobic training (AAE) and continuous aerobic training (SAE). Training lasted three times a week during 6 weeks. In both groups, significant changes were found in evaluation tests scores after the rehabilitation program (p\<0,05). But only AAE group have important statistical difference comparing to SAE group on test time and 6DYT scores.

    Time frame: 30 minutes 3 times a week during 6 weeks

Secondary outcomes

  1. the effect of intermittent and continuous aerobic exercise on life quality

    The participants have no mental and physical disability to join in research. The participants' demographic infos and clinical story were recorded.We evaluate the life quality by using Short Form-36 (SF-36). All evaluation tests are done before and after training. Participants were into randomised two groups: interval aerobic training (AAE) and continuous aerobic training (SAE).After training SAE group showed significant statistical change in every SF-36 parameter, while AAE group showing significant values except energy/fatigue. AAE group have statistically significant changes comparing to SAE group on that parameters; physical function, role limitations due to physical function, role limitations due to emotional function and general health (p\<0,05). Consequently AAE is much more tolerable comparing to SAE and AAE is considered more effective in increasing some parameters. On the other hand, we observed that both training types can be used in cardiac rehabilitation safely.

    Time frame: 30 minutes 3 times a week during 6 weeks

07

Study locations

1 site
  • Physiotherapy and Rehabilitation Center
    Bursa, Turkey (Türkiye)
08

References and documents

Publications

  • Yalcin G, Mutluay F. The effect of interval and continuous aerobic training on exercise capacity and health-related quality of life in people with coronary artery DISEASE: A randomized controlled trial. Respir Med. 2026 Feb;252:108634. doi: 10.1016/j.rmed.2026.108634. Epub 2026 Jan 4. PubMed 41494581 ↗

Individual participant data

Plan to share: Yes — Cardiac rehabilitation is very popular at nowadays and which type exercise good on cardiac rehabilitation is not known exactly

Supporting information: Clinical study report

Time frame: 2 years

Access criteria: karacaoglugulay@gmail.com

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from May 2018 to primary completion in Apr 2019, 10 months.

Of 726 non-industry observational studies under Coronary Artery Disease, half reached primary completion within 48 months of starting (the median), counting those still running; a quarter within 23 and three quarters within 122. This study's 10 months is below that.

Counting every sponsor, half of 857 studies reached it within 43 months; a quarter within 22 and three quarters within 88.

How these figures are worked out, and which studies are left out of them.

Registered
Aug 17, 2019
First posted
Jul 29, 2024
StartActual
May 5, 2018
Primary completionActual
Apr 2, 2019
CompletionActual
May 20, 2019
Last update
Jul 29, 2024
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jul 29, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06525233
Responsible party
gulay karacaoglu (Dr., Istanbul Medipol University Hospital) — Principal investigator
First posted
Jul 29, 2024
Start date
May 5, 2018
Primary completion
Apr 2, 2019
Completion
May 20, 2019
Last update
Jul 29, 2024

Study contacts

Fatma Mutluay
study director · medipol univercity

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Jul 2024. You cannot join it, but the record below documents what was studied.

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