An interventional study of wall squat and passive stretching in Hypertension, sponsored by Chinese University of Hong Kong. Completed at 1 site in Hong Kong. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-12-16.
Sponsored by Chinese University of Hong Kong · Not applicable, Interventional, and Treatment
Background: Isometric resistance exercises (IREs) have great potential to improve blood pressure (BP) control.
Methods: This is a pilot randomized controlled trial that will involve 50 patients with hypertension (HT) who do not meet the current physical activity guidelines defined by the World Health Organization. Participants will be randomly assigned in a 1:1 ratio using stratified and blocked randomization to either the IRE (wall squat) group or stretching exercise (active control) group. A well-structured, widely accepted, and validated 24-week wall squat program (2 minutes per exercise, 2 minutes of rest between sets, and 3 sessions per week) will be implemented, as it has been commonly used in previous research. All patients will be followed up for 24 weeks. Control group will receive exact same treatment except that IRE is replaced by frequency-matched and time-matched stretching exercise. The primary outcome measure will be rate of recruitment. Secondary outcomes will include BP parameters from 24-hour ambulatory BP monitoring
6,689 studies on the registry are indexed under Hypertension; 965 are open to participants now.
This study's enrollment of 50 is below the median of 90 across 4,995 interventional studies indexed under Hypertension.
Browse Hypertension studies →Chinese University of Hong Kong is the lead sponsor of 1,419 studies on the registry; 487 are open to participants now.
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Exclusion Criteria:
wall squat exercise. Each exercise session will contain 4 sets of 2-minute wall squat isometric holds with 2 minutes of rest between each set (approximately 14 minutes per session in total), and a total of 3 sessions will be arranged every week (with ideally 48 h between exercises)
Behavioral: wall squat
A frequency-matched (3x/week) and time-matched (\~14 minutes each session) passive static stretching exercise will be used
Behavioral: passive stretching
self-learnt wall squat exercise to be conducted for totally 24 weeks
time-matched passive stretching exercise to be conducted for totally 24 weeks
rate of recruitment
number of people recruited per month
Time frame: through study completion, an average of 1 year
Blood pressure parameters
24-hour, daytime and nighttime blood pressure from 24-hour ambulatory systolic and diastolic blood pressure measurement
Time frame: 24-week after recruitment
Carotid-femoral pulse wave velocity
analysed by applanation tonometry using SphygmoCor (AtCor Medical Pty Ltd) with the accompanying SphygmoCor Software Suite (SphygmoCor System)
Time frame: 24-week after recruitment
flow-mediated velocity (FMD)
FMD will be performed using a high-resolution linear artery transducer couple with a software (FMD suite, Quipu, Italy) that automatically detect and measure the brachial artery diameter and will be performed according to international guidelines
Time frame: 24-week after recruitment
Plan to share: Yes
No publications or documents are linked to this record.
This study is completed, as verified in Nov 2025. You cannot join it, but the record below documents what was studied.
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Chinese University of Hong Kong