An interventional study of Low-intensity extracorporeal shock wave in Diabetic Nephropathy, sponsored by South Valley University. Not yet recruiting. Open to participants aged 40 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-07-01.
Sponsored by South Valley University · Not applicable, Interventional, and Treatment
In our thesis, we will compare the effectiveness of low-intensity shock wave versus acetylcholine iontophoresis as a possible new therapy for microcirculation changes in type 2 diabetic neuropathy
Methods: A group of 80 patients (male and female) diagnosed with type 2 diabetes mellitus, was included in the study. Their age ranged from 40-60 years. Patients randomly will be divided into two groups: Study groups (A) 40 patients with type 2 diabetes mellitus with clinically proven peripheral neuropathy. And study group (B) 40 patients with type 2 diabetes mellitus with clinically proven peripheral neuropathy. They were selected from South Valley University Hospitals. Group A received low-intensity extracorporeal shock wave therapy Li-ESWT (3 Hz, 0.09 mJ/mm2, 300 pulses), for two sessions per week for six weeks. Study group (B) received iontophoresis by acetylcholine current intensity of 3 to 5 mA. Check skin every 3-5 minutes for signs of skin irritation with (15) min for three sessions per week for four weeks. Nitric oxide level and the electrophysiology (EMG) of peripheral nerves and muscles were measured pre and post-treatment.
617 studies on the registry are indexed under Diabetic Neuropathies; 91 are open to participants now.
This study's planned enrollment of 80 is close to the median of 73 across 510 interventional studies indexed under Diabetic Neuropathies.
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Exclusion Criteria:
Study group A will receive low-intensity extracorporeal shock wave therapy Li-ESWT (3 Hz, 0.09 mJ/mm2, 300 pulses), for two sessions per week for six weeks. Nitric oxide level and the electrophysiology (EMG) of peripheral nerves and muscles were measured pre and post-treatment.
Device: Low-intensity extracorporeal shock wave
Study group (B) will receive iontophoresis by acetylcholine current intensity of 3 to 5 mA. Check skin every 3-5 minutes for signs of skin irritation with (15) min for three sessions per week for six weeks. Nitric oxide level and the electrophysiology (EMG) of peripheral nerves and muscles were measured pre and post-treatment.
Device: Low-intensity extracorporeal shock wave
Acetylcholine iontophoresis• The Iontophoresis comprises of electric impulses from a low voltage galvanic current stimulation unit to drive ions (Ach) (1%) into soft tissue structures.
Also known as: Device, ASTAR Swit 33, 43-382 dual-channel Stimulator (Bielsko-Biata, Poland) 230V-, 50/60 HZ, max 70 W, 100VA, was used.
Electrophysiological investigations of peripheral nerves (latency, amplitude and velocity of peripheral nerves)
Electrophysiological investigations of peripheral nerves were measured pre and post treatment for both groups (latency, amplitude and velocity of peripheral nerves)
Time frame: Six weeks
Nitric oxide laboratories for measurement of nitric oxide level
Nitric oxide laboratories for measurement of nitric oxide level were measured pre and post treatment for both groups.
Time frame: Six weeks
No study locations are listed for this record.
Plan to share: Undecided — After publication
This study is not yet recruiting, as verified in Jun 2024. You cannot join it, but the record below documents what was studied.
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South Valley University