ClinicalTrials.gg
Not yet recruitingNCT06476080Updated Jun 27, 2024

Ultrasound Guided Serratus Anterior Versus Erector Spinae Block in Pain Alleviation in Acute Herpes Zoster

An interventional study of ultrasound guided erector spine block and Serratus anterior block in Acute Herpes Zoster Neuropathy, sponsored by Minia University. Not yet recruiting. Open to participants aged 30 Years to 75 Years. Per ClinicalTrials.gov, last updated 2024-06-27.

Sponsored by Minia University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Apr 2025, 1 year 6 months ago, but the record still lists the study as not yet recruiting.
Phase
Not applicable
Study type
Interventional
Enrollment
120
Allocation
Randomized
Ages
30 Years to 75 Years
Sex
All
01

Study summary

Acute herpes zoster pain is very severe . Conventional analgesics may be of no value. Regional blocks may play a role

02

Conditions studied

  • Acute Herpes Zoster Neuropathy

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03

In context

Herpes Zoster

299 studies on the registry are indexed under Herpes Zoster; 55 are open to participants now.

This study's planned enrollment of 120 is below the median of 160 across 247 interventional studies indexed under Herpes Zoster.

Browse Herpes Zoster studies →

Lead sponsor

Minia University is the lead sponsor of 370 studies on the registry; 117 are open to participants now.

Of its 6 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
30 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Adult population between 30 and 75 years old.
  • Unilateral painful thoracic herpetic eruption of less than one week duration.
  • VAS more than or equal 4, persistent pain in spite of proper antiviral and analgesic therapy, (800 mg oral acyclovir, 5 times per day, for one week), pregabalin 300 mg per day, acetaminophen 1000 mg per day, topical calamine lotion).

Exclusion criteria

Exclusion Criteria:

  • Diabetic patients.
  • Painful herpetic eruptive vesicles more than one week.
  • Abdominal herpetic eruptions.
  • Non-compliant on anti-viral (bulbar palsy for example).
  • Co- or radiotherapy.
  • therapy > 5 mg prednisolone or its equivalent.
  • Infections or hematoma at site of injection.
  • Coagulopathy (chronic kidney or liver disease, clopidogrel use).
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Cancer (malignancy)

Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.

Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.

Corticosteroids (steroids)

Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.

Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
120 participants (estimated)

Study arms

  • No intervention
    Control group

    800 mg acyclovir, 5 times / day, orally administered, for one week, acetaminophen 1000 mg per day, topical calamine lotion)

  • Active comparator
    Erector spinae group

    800 mg acyclovir, 5 times / day, orally administered, for one week, acetaminophen 1000 mg per day, topical calamine lotion)+ 25 ml bupivacaine 0.25% plus 8 mg dexamethasone

    Procedure: ultrasound guided erector spine block

  • Active comparator
    Serratus anterior group

    800 mg acyclovir, 5 times / day, orally administered, for one week, acetaminophen 1000 mg per day, topical calamine lotion)+ 25 ml bupivacaine 0.25% plus 8 mg dexamethasone

    Procedure: Serratus anterior block

Interventions

  • Procedureultrasound guided erector spine block

    Ultrasound guided thoracic erector spinae block

  • ProcedureSerratus anterior block

    Ultrasound guided serratus anterior block

06

What researchers measure

Primary outcomes

  1. pain score

    Visual analogue scale from 0 to 10. 0= NO pain, 1-3=mild tolerable pain, 4-6= moderate pain, 7-10= severe untearable pain.

    Time frame: immediate after injection, 1 week, 1, 3 months

Secondary outcomes

  1. Number of patients with pain recurrence

    Number of patients in need for re-injection

    Time frame: 1 week, 1, and 3 months

  2. analgesic consumption

    total amount dose of analgesics used

    Time frame: 1 week, 1, and 3 months

  3. Incidence of treatment related adverse events

    hypotension, bradyarrhythmia, hematoma

    Time frame: immediately after injection

07

Study locations

No study locations are listed for this record.

08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Start is estimated for Jul 2024; primary completion for Apr 2025, 9 months later.

Of 34 interventional studies with no phase under Herpes Zoster, half reached primary completion within 13 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 24. This study's planned 9 months is below that.

How these figures are worked out, and which studies are left out of them.

Registered
Jun 15, 2024
First posted
Jun 26, 2024
StartEst.
Jul 5, 2024
Primary completionEst.
Apr 15, 2025
CompletionEst.
Apr 15, 2025
Last update
Jun 27, 2024
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Jun 27, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06476080
Lead sponsor
Minia University
Responsible party
Mina Maher (Ass professor anesthesia and pain, Minia University) — Principal investigator
First posted
Jun 26, 2024
Start date
Jul 5, 2024 (estimated)
Primary completion
Apr 15, 2025 (estimated)
Completion
Apr 15, 2025 (estimated)
Last update
Jun 27, 2024

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Jun 2024. You cannot join it, but the record below documents what was studied.

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