An interventional study of Medication Reviews and Deprescribing in Medication Overuse, Deprescriptions and Polypharmacy, sponsored by University of Crete. Active, not recruiting at 1 site in Greece. Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2026-02-09.
Sponsored by University of Crete · Not applicable, Interventional, and Other
Polypharmacy is a common and growing public health concern across healthcare settings worldwide and is associated with an increased risk of inappropriate prescribing and adverse drug events. Deprescribing-defined as the supervised withdrawal of potentially inappropriate medications using structured tools and clinical judgment-has been proposed as a strategy to improve prescribing safety. In Greece, formal initiatives and evidence evaluating deprescribing interventions in primary care remain limited.
This study is a cluster randomized controlled trial evaluating the effect of an educational intervention for general practitioners (GPs) on prescribing safety in primary care. Participating GPs are randomized in an approximately 1:1 ratio to an intervention or control arm. GPs in the intervention arm receive structured education and training on medication review and deprescribing, including the use of validated deprescribing tools such as the Beers Criteria. GPs in the control arm provide usual care and do not receive any educational intervention.
Patients receiving care from participating GPs are recruited, and prescribing outcomes are assessed at the patient level. The primary outcome is change in prescription medications following the intervention, comparing patients cared for by GPs in the intervention arm versus those cared for by GPs in the control arm.
9 studies on the registry are indexed under Prescription Drug Overuse; none are open to participants now.
Browse Prescription Drug Overuse studies →University of Crete is the lead sponsor of 23 studies on the registry; 6 are open to participants now.
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Exclusion Criteria:
An educational intervention and training in deprescribing algorithms and deprescribing tools ( Beers Criteria) will be provided to the general practitioners caring for the patients selected in the intervention arm.
Other: Medication Reviews and Deprescribing
No educational intervention will be provided to the general practitioners of the selected patients.
General Practitioners will be given training and education in deprescribing algorithms and the conduction of medication reviews with the use of validated deprescribing tools such as the Beers Criteria.
Potentially Inappropriate Medication
Determine if there is reduction in potentially Inappropriate medication after a deprescribing education intervention
Time frame: 1 years
Number of medications
Determine if there is reduction in number of medications after a deprescribing education intervention
Time frame: 1 year
Plan to share: No — All the data that will be collected, will be retained only during the period needed for the aims of this research. Technical and organizational measures will be taken in order to minimize potential loss, destruction or corruption of the data.After the completion of the thesis , all the data will be destroyed.
No publications or documents are linked to this record.
Ran from Nov 2024 to primary completion in Dec 2025, 13 months.
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This study is active, not recruiting, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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University of Crete