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Active, not recruitingNCT06467877Updated Dec 9, 2024

Causes, Characteristics and Treatment of Hypercalcemia in the Emergency Room of a German Hospital

An observational study in Hypercalcemia, sponsored by University of Cologne. Active, not recruiting at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-12-09.

Sponsored by University of Cologne · Observational

Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
200
Ages
18 Years and older
Sex
All
01

Study summary

Patients with hypercalcemia were identified in the patient population of a German emergency department during a 11 year time period and studied regarding reproducibility of elevated calcium values, causes of hypercalcemia, symptoms. acute renal injury, mortality and treatment response.

Read the detailed description

Patients, who presented to the emergency department of a tertiary German hospital with a total calcium of ≥2.65 mmol/l between January 2010 and March 2021, was retrospectively studied. From the electronic patient records we analyzed if the elevated calcium values were reproducible in follow-up measurements, identified the cause of hypercalcemia, listed the symptoms, investigated a correlation between calcium and creatinine values to study acute renal injury directly due to hypercalcemia, calculated the mortality rate stratified by the calcium value on presentation and studied the treatment response regarding lowering calcium values by different treatments.

02

Conditions studied

  • Hypercalcemia

Keywords

  • hypercalcemia
  • calcium
  • emergency room
  • mortality
03

In context

Hypercalcemia

47 studies on the registry are indexed under Hypercalcemia; 8 are open to participants now.

This study's enrollment of 200 is close to the median of 185 across 13 observational studies indexed under Hypercalcemia.

Browse Hypercalcemia studies →

Lead sponsor

University of Cologne is the lead sponsor of 203 studies on the registry; 26 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients reporting to the Emergency Room of the University Hospital Cologne and recieved a determination of the total calcium level

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Age > 18 years
  • Total calcium ≥ 2.65 mmol/l
  • Female and male

Exclusion criteria

Exclusion Criteria:

  • Age \< 18 years
  • Total calcium \< 2.65 mmol/
05

Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
200 participants (actual)
Patient registry
No

Groups and cohorts

  • Retrospective Chart Review

    Group includes patient with hypercalcemia ≥2.65 mmol/l, who reported to the emergency room of a tertiary hospital

06

What researchers measure

Primary outcomes

  1. Development of total calcium values

    Overview of total calcium values within 5 days

    Time frame: 5 days after enrollment

Secondary outcomes

  1. Reproducibility of elevated calcium values

    Determination of cause of hypercalcemia, of symptoms, of treatment response. In dependence of hospital stay, kann be determined later than 5 days after enrollment

    Time frame: 5 days after enrollment

  2. Correlation creatinine calcium

    Determination of correlation between calcium and creatinine.

    Time frame: 5 days after enrollment

  3. Mortality

    occurence of death within of 5 days after enrollment

    Time frame: 5 days after enrollment

07

Study locations

1 site
  • Department II of Internal Medicine,University of Cologne
    Cologne, 50937, Germany
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 9, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06467877
Responsible party
Volker Burst (Prof. Dr. med., University of Cologne) — Principal investigator
First posted
Jun 21, 2024
Start date
Jan 1, 2010
Primary completion
Mar 31, 2021
Completion
Dec 31, 2025 (estimated)
Last update
Dec 9, 2024

Study contacts

Volker Burst, MD
principal investigator · University Hospital of Cologne

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is active, not recruiting, as verified in Dec 2024. You cannot join it, but the record below documents what was studied.

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