An observational study in Ventricular Remodeling and Myocardial Infarction, Anterior Wall, sponsored by The First Affiliated Hospital with Nanjing Medical University. Recruiting at 1 site in China. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2024-06-18.
Sponsored by The First Affiliated Hospital with Nanjing Medical University · Observational
This study is designed to evaluate the efficacy and safety of Recombinant Human Brain Natriuretic Peptide (rhBNP) in improving ventricular remodeling and cardiac function after acute anterior myocardial infarction undergoing percutaneous coronary intervention. 100 patients with acute anterior myocardial infarction after primary Percutaneous Coronary Intervention (pPCI) are randomly assigned 1:1 to rhBNP group(n=50) and control group(n=50) with follow-up of 24 weeks. Both groups are treated with standard therapy of AAMI, with the rhBNP group intravenous dripping rhBNP after pPCI for 3 days and the control group treated with placebo at the same time. The primary endpoint is the change in N terminal pro-B-type natriuretic peptide（NT-proBNP ）and cardiac troponin T(cTnT) level.The secondary endpoint is the change in 24-week echocardiographic including left ventricle ejection fraction (LVEF) , left ventricular end-diastolic volume index (LVEDVI) and left ventricular end-systolic volume index (LVESVI), arrhythmia and cardiovascular events (death, cardiac arrest or cardiopulmonary resuscitation, hospitalization due to heart failure or angina pectoris).
105 studies on the registry are indexed under Ventricular Remodeling; 24 are open to participants now.
This study's planned enrollment of 100 is below the median of 180 across 32 observational studies indexed under Ventricular Remodeling.
Browse Ventricular Remodeling studies →The First Affiliated Hospital with Nanjing Medical University is the lead sponsor of 568 studies on the registry; 317 are open to participants now.
Counted across the registry records on this site, refreshed daily.
People who are about 18 to 75 years old get the first acute anterior myocardial infarction ( AMI ) within 12 hours ( or more than 12 hours but the ischemic symptoms continue ) and undergo emergency PCI within the effective time window,after which the blood reflows ( TIMI = 3 ).
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria：
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Drug: Recombinant Human Brain Natriuretic Peptide
we divide our subjects into two groups;one is required to take recombinant human brain natriuretic peptide,the other is not required to take recombinant human brain natriuretic peptide
ultrasonic cardiogram：left ventricle ejection fraction (LVEF)
LVEF refers to the percentage of stroke output to left ventricular end-diastolic
Time frame: from baseline to 6 months
ultrasonic cardiogram：left ventricular end-diastolic volume index (LVEDVI)
LVEDVI（ml/m2）=left ventricular end-diastolic volume（ml）/body surface area
Time frame: from baseline to 6 months
ultrasonic cardiogram：left ventricular end-systolic volume index (LVESVI)
LVESVI（ml/m2）=left ventricular end-systolic volume（ml）/body surface area
Time frame: from baseline to 6 months
N terminal pro-B-type natriuretic peptide（NT-proBNP ）decline level
NT-proBNP is a protein which is an "ingredient" for making the BNP hormone and a sign of heart failure can be obteined by blood
Time frame: from baseline to 6 months
The level of Cardiac Troponin T(cTnT)
The level of Cardiac Troponin T(cTnT) at 6 month
Time frame: from baseline to 6 months
Adverse cardiovascular events
Time frame: from baseline to 6 months
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The First Affiliated Hospital with Nanjing Medical University →