An observational study in Carotid Stenosis, sponsored by Beijing Tiantan Hospital. Enrolling by invitation at 1 site in China. Per ClinicalTrials.gov, last updated 2024-06-13.
Sponsored by Beijing Tiantan Hospital · Observational
Atherosclerotic carotid artery stenosis is a major cause of stroke, and early identification of high-risk patients combined with surgical intervention can significantly reduce stroke risk. Currently, stroke risk assessment in patients with carotid artery stenosis primarily relies on imaging indicators such as plaque morphology, composition, and degree of stenosis, with less emphasis on indicators directly related to inflammation, hemodynamics, and plaque instability. Certain circulating metabolites are closely linked to plaque progression and are direct risk factors for stroke. However, there is a lack of stroke risk prediction models for patients with carotid stenosis that incorporate these indicators, and the ability to identify high-risk patients needs improvement.
This study proposes using deep learning technology to integrate multidimensional data from plaque imaging, fluid dynamics, circulating metabolomics, and proteomics to construct an accurate prediction model for cerebrovascular events in patients with carotid artery stenosis. Additionally, it aims to explore markers of plaque instability characteristics based on plaque pathology. The study is expected to provide a basis for identifying high-risk patients with carotid artery stenosis, thereby laying the foundation for reducing stroke risk and improving long-term patient outcomes.
339 studies on the registry are indexed under Carotid Stenosis; 81 are open to participants now.
This study's planned enrollment of 300 is above the median of 173 across 144 observational studies indexed under Carotid Stenosis.
Browse Carotid Stenosis studies →Beijing Tiantan Hospital is the lead sponsor of 465 studies on the registry; 282 are open to participants now.
Counted across the registry records on this site, refreshed daily.
All patients who met the enrollment criteria at Beijing Tiantan Hospital.
Exclusion Criteria:
Patients with cerebrovascular events within six months, including i. cerebral infarction in the middle cerebral artery territory on the side of carotid stenosis; ii. transient ischemic attack symptoms (including motor and sensory) in the hemisphere on the side of stenosis; and iii. transient amaurosis on the side of stenosis. This indicates an unstable condition and such patients are defined as high-risk carotid stenosis patients.
Diagnostic Test: Plasma · Diagnostic Test: carotid high-resolution magnetic resonance imaging
Patients without cerebrovascular events within six months are defined as low-risk carotid stenosis patients.
Diagnostic Test: Plasma · Diagnostic Test: carotid high-resolution magnetic resonance imaging
Plasma levels of metabolites and some proteins will be further determined
Define plaque composition and morphological characteristics
Number of Patients with Cerebrovascular Events
Patients will be categorized as having a cerebrovascular event if they meet one of the following indicators: i. cerebral infarction in the middle cerebral artery territory on the side of carotid stenosis; ii. transient ischemic attack symptoms (including motor and sensory) in the hemisphere on the side of stenosis; and iii. transient amaurosis on the side of stenosis.
Time frame: Within six months from the date of consultation
Plan to share: No
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Beijing Tiantan Hospital