A Phase 4 interventional study of Atropine Ophthalmic and MiSight 1-day disposable contact lenses in Myopia, sponsored by Ohio State University. Active, not recruiting at 1 site in United States. Open to participants aged 21 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-01-27.
Sponsored by Ohio State University · Phase 4, Interventional, and Basic science
The goal of this clinical trial is to study changes in eye shape of nearsighted young adults using low-dose atropine eye drops or soft multifocal contact lenses. The main questions it aims to answer are:
Participants will:
Researchers will compare young adults using low-dose atropine to those wearing soft multifocal contact lenses and to those using no intervention to see if using these interventions affects retinal shape.
984 studies on the registry are indexed under Myopia; 210 are open to participants now.
This study's planned enrollment of 75 is close to the median of 80 across 783 interventional studies indexed under Myopia.
Browse Myopia studies →Ohio State University is the lead sponsor of 640 studies on the registry; 144 are open to participants now.
Of its 60 completed or terminated interventional studies of FDA-regulated products, 45 (75%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Participants randomized to the observation arm will receive no intervention.
Participants randomized to low-dose atropine will instill one drop of 0.05% atropine in each eye at bedtime for 12 months.
Drug: Atropine Ophthalmic
Participants randomized to soft multifocal contact lenses will wear MiSight 1-day disposable contact lenses for 5-7 days per week for 12 months.
Device: MiSight 1-day disposable contact lenses
0.05% atropine ophthalmic solution
soft multifocal contact lenses
Change in ocular shape
ocular shape, as measured by the ellipsoid fit of the retina acquired by the photos taken with ocular ultrasound (ABSolu, Quantel Medical)
Time frame: baseline to 12 months
Axial elongation (or regression)
change in axial length of the eye, as measured by Lenstar 900 (Haag-Streit)
Time frame: baseline to 12 months
Change in accommodative response
change in focusing ability of the eye, as measured with near targets and the Grand Seiko WR-5100K
Time frame: baseline to 12 months
Change in refractive error
change in refractive error, as measured with the Grand Seiko WR-5100K
Time frame: baseline to 12 months
Plan to share: No
No publications or documents are linked to this record.
This study is active, not recruiting, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Ohio State University