CClinicalTrials.gg
CompletedNCT06405919Updated May 9, 2024

Risk of Malignancy in Endemic Long Standing Nodular Goitres: a Prospective Cohort Study

An observational study in Incidence of Thyroid Cancer in Long Standing MNG, sponsored by University of Khartoum. Completed at 1 site in Sudan. Per ClinicalTrials.gov, last updated 2024-05-09.

Sponsored by University of Khartoum · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
160
Sex
All
01

Study summary

To determine the incidence of thyroid cancer in patients with long standing goitres presenting for surgery.

Read the detailed description

This is a prospective cohort study The objective is to determine the incidence of cancer in patients with long standing goitres( more than 10 years ) who present for surgery in Khartoum Teaching Hopspital - Sudan.

Introduction: goitre is endemic in Sudan with prevalence ranging between 5-42% in different regions of the country. Patients are referred for surgery only if they develop pressure symptoms.

The incidence of thyroid carcinoma is high in endemic goitrous areas. Determining the risk of cancer in patient with long standing goitres may help in early early referral and early surgical intervention.

Methods: This is prospective cohort study including 160 patients with long standing goitrers of 10 years or more who presented from March 2017 to September 2017 to Khartoum Teaching Hospital-Sudan

02

Conditions studied

  • Incidence of Thyroid Cancer in Long Standing MNG

Keywords

  • : goitre, long standing, malignant risk, incidental.
03

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients with long standing goitres presenting for surgery in Khartoum Teaching Hospital March 2017-September 2018

Inclusion criteria

  • All patients with long standing goitres of 10 years or more

Exclusion criteria

Exclusion Criteria:

  • Non
04

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
160 participants (actual)
Patient registry
No
Biospecimen retention
Samples without dna

Groups and cohorts

  • Patients with goitres 10 years or more

    Patients with long standing multinodular goitres of 10years or more presenting to surgical unit in Khartoum Teaching Hospital -Sudan. Checking incidence of malignancy in this group.

    Diagnostic Test: Histopathology

Interventions

  • Diagnostic testHistopathology

    Thyroidectomy for patients and histological examination of specimen to determine incidence of malignancy.

05

What researchers measure

Primary outcomes

  1. Rate of malignancy

    Rate of malignancy in resected goitre specimens

    Time frame: March 2017-September 2018

06

Study locations

1 site
  • Faculty of Medicine University of Khartoum
    Khartoum, 11111, Sudan
07

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT06405919
Lead sponsor
University of Khartoum
Collaborators
Sudan Medical Specialization Board
Responsible party
Seifeldin Mahdi (Associate professor of surgery, University of Khartoum) — Principal investigator
First posted
May 9, 2024
Start date
Mar 1, 2017
Primary completion
Sep 30, 2018
Completion
Sep 30, 2018
Last update
May 9, 2024

Study contacts

Mohamed Elmakki Abdella, MS,FRCSI
study director · University of Khartoum -Faculty of Medicine

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2024. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion