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Not yet recruitingNCT06399484Updated May 3, 2024

In Patients With Carpal Tunnel Syndrome, Median Nerve Conduction is Evaluated After Nerve Mobilizations

An interventional study of Manual mobilizations of the median nerve and Wrist movements in Carpal Tunnel Syndrome, sponsored by Universidad de Zaragoza. Not yet recruiting at 1 site in Spain. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-05-03.

Sponsored by Universidad de Zaragoza · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Primary completion was expected by Sep 2024, 2 years ago, but the record still lists the study as not yet recruiting.
Phase
Not applicable
Study type
Interventional
Enrollment
30
Allocation
Randomized
Ages
18 Years and older
Sex
All
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Study summary

This project is linked to the line of research on carpal tunnel syndrome, of the PhysiUZerapy research group, belonging to the University of Zaragoza. Within this line, the biomechanical and physiological effect of the proposed technique has been investigated, both in healthy subjects, in cadavers and in patients with carpal tunnel syndrome (CTS), resulting in the reading of 2 doctoral theses, the publication of 9 articles in high-impact journals. and the patent for a splint for the treatment of pathology. This project aims to provide information that is still lacking on the immediate effect of these techniques in patients with CTS. For this, there will be three groups of patients from the Lozano Blesa University Clinical Hospital distributed randomly. In two of the groups, sliding and neural tension techniques will be carried out (case group). The remaining group (control group) will be taken as a reference by performing a placebo treatment. Before and after carrying out these techniques, electrophysiological data will be collected to be able to compare them. This comparison is based on highlighting the differences between the data before the techniques and after, as well as between the case group and the control group.

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Conditions studied

  • Carpal Tunnel Syndrome
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In context

Carpal Tunnel Syndrome

589 studies on the registry are indexed under Carpal Tunnel Syndrome; 140 are open to participants now.

This study's planned enrollment of 30 is below the median of 60 across 445 interventional studies indexed under Carpal Tunnel Syndrome.

Browse Carpal Tunnel Syndrome studies →

Lead sponsor

Universidad de Zaragoza is the lead sponsor of 109 studies on the registry; 19 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Being over 18 years
  • Present carpal tunnel syndrome diagnosed by electroneurogram
  • Have understanding and communication skills
  • Give consent to participate in the study

Exclusion criteria

Exclusion Criteria:

  • Have received previous surgery on the hand or wrist
  • Present a severe limitation of movement in any of the joints of the affected upper limb
  • Not signing the informed consent
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Care provider)
Enrollment
30 participants (estimated)

Study arms

  • Experimental
    Neural mobilization group

    Manual mobilizations of the median nerve.

    Other: Manual mobilizations of the median nerve

  • Placebo comparator
    Placebo group

    wrist movements no producing sliding of the median nerve

    Other: Wrist movements

Interventions

  • OtherManual mobilizations of the median nerve

    Slippage of the median nerve in the wrist: the subject's starting position (P0) will be recumbent supine with the cervical spine in a neutral position, the shoulder girdle in neutral position, 30º of glenohumeral abduction in neutral rotation, 90º of elbow flexion, prone-supination of the neutral forearm, wrist and fingers in neutral position. From this position the movements will be 1) Glenohumeral abduction up to 90º; 2) Glenohumeral external rotation to the frontal plane; 3) Supination of the forearm; 4) Extension of the wrist and fingers; 5) Elbow extension. This position is will combine with an ipsilateral cervical inclination (distal sliding). The proximal slide is carried out bringing the fingers of the hand towards the flexion while performing a contralateral cervical tilt. Median nerve tension: the starting position and movements are the same described above but this time it will be done with contralateral cervical tilt.

  • OtherWrist movements

    Movements of the wrist joint will be performed as a placebo treatment

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What researchers measure

Primary outcomes

  1. Distal motor latency (APB) (ms)

    Time frame: Before and immediately after the intervention

  2. Motor amplitude (APB) (mV)

    Time frame: Before and immediately after the intervention

  3. Median motor velocity (m/s)

    Time frame: Before and immediately after the intervention

  4. Median sensory conduction (digit II) (13 cm) (m/sec)

    Time frame: Before and immediately after the intervention

  5. Sensory amplitude (µV)

    Time frame: Before and immediately after the intervention

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Study locations

1 site
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References and documents

Study documents

  • Informed consent form · Oct 10, 2023

Documents are hosted by the registry — open the source record to download them.

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 3, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06399484
Lead sponsor
Universidad de Zaragoza
Responsible party
Elena Bueno Gracia (Physiotherapist, PhD, Universidad de Zaragoza) — Principal investigator
First posted
May 3, 2024
Start date
Jun 15, 2024 (estimated)
Primary completion
Sep 15, 2024 (estimated)
Completion
Dec 15, 2024 (estimated)
Last update
May 3, 2024

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in May 2024. You cannot join it, but the record below documents what was studied.

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