An interventional study of 6-minute walk distance (6MWD) test on ambient air and 6-minute walk distance test with supplemental oxygen in Pulmonary Vascular Disorder, Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Arterial Hypertension, sponsored by University of Zurich. Completed at 1 site in Switzerland. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-12-10.
Sponsored by University of Zurich · Not applicable, Interventional, and Other
The investigators aim to study the effect of SOT in Swiss residents with pulmonary vascular diseases (PVD) defined as pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH).
Participants with PVD diagnosed with precapillary PH with right heart catheterization and classified to groups 1 and 4 (PAH or CTEPH) who live in Switzerland will have 6-minute walk distance (6MWD) test with and without SOT approximately 3l/min via nasal cannula according to a randomized cross-over design.
The trial aims to test that the 6MWD with SOT is non-inferior to a 6MWD in the same participant under ambient air.
The effect size was estimated with a difference of less or equal to 35m compared under SOT compared to ambient air.
761 studies on the registry are indexed under Pulmonary Arterial Hypertension; 142 are open to participants now.
This study's enrollment of 40 is close to the median of 38 across 509 interventional studies indexed under Pulmonary Arterial Hypertension.
Browse Pulmonary Arterial Hypertension studies →University of Zurich is the lead sponsor of 1,030 studies on the registry; 130 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Patient will perform tests at University Hospital Zurich
Other: 6-minute walk distance (6MWD) test on ambient air
Supplemental Oxygen Therapy (SOT) at approximately 3l/min will be provided via nasal canula from a small oxygen concentrator while the patient performs tests at University Hospital Zurich.
Other: 6-minute walk distance test with supplemental oxygen
6-minute walk distance (6MWD) test will be performed on ambient air according to clinical standards
6-minute walk distance (6MWD) test will be performed according to clinical standards additionally with supplemental oxygen therapy (approximately 3l/min, nasal)
6-minute walk distance (6MWD) with supplemental oxygen therapy (SOT) vs. ambient air
Change in 6MWD in meter between SOT via nasal cannula vs. ambient air
Time frame: after 6 minutes
SpO2 at rest and peak 6MWD with SOT vs. ambient air
Change of the arterial oxygen saturation by pulse oximeter (SpO2) at rest and at peak 6MWD with SOT approximately 3l /min vs. ambient air
Time frame: after 6 minutes
Heart rate at rest and peak 6MWD with SOT vs. ambient air
Change of heart rate (bpm) at rest and at peak 6MWD with SOT vs. ambient air
Time frame: after 6 minutes
Borg dyspnea atrest and peak 6MWD with SOT vs. ambient air
Change of Borg dyspnea scale (CR10, 0-10 where 10 is the worst dyspnea) at rest and at peak 6MWD with SOT vs. ambient air
Time frame: 6 minutes
Borg leg fatigue scale at rest and peak 6MWD with SOT vs. ambient air
Change of Borg leg fatigue scale (CR10, 0-10 where 10 is the strongest led fatugue) at rest and at peak 6MWD with SOT vs. ambient air
Time frame: 6 minutes
Blood pressure at rest and peak 6MWD with SOT vs. ambient air
Change of Blood pressure (mmHg) at rest and at peak 6MWD with SOT vs. ambient air
Time frame: after 6 minutes
Plan to share: Yes — Data will be provided upon request and based on a clear intention reviewed by an ethical review board
No publications or documents are linked to this record.
This study is completed, as verified in Dec 2025. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Pulmonary Arterial Hypertension→
University of Zurich