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RecruitingNCT06382740Over70-LTUpdated Apr 24, 2024

Selection Protocol for Liver Transplantation in Patients Aged Over 70 Years

An observational study in End Stage Liver DIsease, Liver Transplantation and Old Age, sponsored by Azienda Ospedaliera di Padova. Recruiting at 1 site in Italy. Open to participants aged 71 Years to 75 Years. Per ClinicalTrials.gov, last updated 2024-04-24.

Sponsored by Azienda Ospedaliera di Padova · Observational

From the registry’s dates

  • Primary completion was expected by Oct 2025, 1 year ago, but the record still lists the study as recruiting.
  • Started Oct 2022; still recruiting 4 years later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
18
Ages
71 Years to 75 Years
Sex
All
01

Study summary

Increased life expectancy and aging population has led to a trend of increasing liver transplant (LT) volume in the elderly. Nowadays, advanced age is not considered an absolute contraindication for LT but elderly LT candidates typically have an age-associated burden of comorbid conditions that can pose several clinical challenges during the selection/evaluation process for LT. Specific algorithms for elderly patient selection for LT are not well established; however, consensus agreement is that elderly LT candidates need a more rigorous selection process.

This study proposes a "step by step" algorithm of selection for liver transplant candidates more than 70 years.

02

Conditions studied

  • End Stage Liver DIsease
  • Liver Transplantation
  • Old Age

Keywords

  • liver transplantation
  • old recipients
  • age>70 years
03

In context

Liver Diseases

2,083 studies on the registry are indexed under Liver Diseases; 392 are open to participants now.

This study's planned enrollment of 18 is below the median of 167 across 683 observational studies indexed under Liver Diseases.

Browse Liver Diseases studies →

Lead sponsor

Azienda Ospedaliera di Padova is the lead sponsor of 36 studies on the registry; 13 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
71 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Consecutive candidates for liver transplant with age >70 and ≤ 75 years

Inclusion criteria

  • Age >70 years and ≤ 75 years
  • Liver transplant from cadaveric donor
  • First liver transplant
  • End stage liver disease or liver tumor

Exclusion criteria

Exclusion Criteria:

  • Age ≤ 70 years
  • Living donor liver transplant
  • Previous liver transplant
  • Liver transplant for acute liver failure
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
18 participants (estimated)
Patient registry
No

Interventions

  • ProcedureLiver transplantation

    Liver transplantation

06

What researchers measure

Primary outcomes

  1. 1 year patient survival

    Overall patients survival at 12 months from liver transplantation

    Time frame: 12 months

Secondary outcomes

  1. 1 year graft survival

    Overall graft survival at 12 months from liver transplantation

    Time frame: 12 months

  2. 3 months mortality and morbidity

    Mortality and morbidity rates at 3 months from liver transplantation

    Time frame: 3 months

07

Study locations

1 of 1 sites recruiting
  • U.O.C Chirurgia Epatobiliare e Trapianti Epatici, Azienda Ospedaliera di Padova
    Padova, 35128, Italy
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 24, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT06382740
Lead sponsor
Azienda Ospedaliera di Padova
Responsible party
Prof. Umberto Cillo (Director, Azienda Ospedaliera di Padova) — Principal investigator
First posted
Apr 24, 2024
Start date
Oct 1, 2022
Primary completion
Oct 1, 2025 (estimated)
Completion
Oct 1, 2025 (estimated)
Last update
Apr 24, 2024

Study contacts

Umberto Cillo, Prof
Contact
cillo@unipd.it
049.8212211-1897
Alessandro Vitale, Prof
Contact
alessandro.vitale@unipd.it
Umberto Cillo, Prof
principal investigator · Azienda Ospedaliera di Padova

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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