An observational study in Myasthenia Gravis, Neuromuscular Manifestations and Neuromuscular Diseases, sponsored by ZS Associates. Completed at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-25.
Sponsored by ZS Associates · Observational
This is a fully remote, site-less, prospective, observational study enrolling adults in the United States (excluding U.S. territories) with undiagnosed neuromuscular symptoms. The main study objective is to evaluate the feasibility of a social media recruitment campaign tied to a participant reported symptom survey and self-administered physical assessment tool to influence undiagnosed participants to seek care for suspected Myasthenia Gravis (MG).
Participants with undiagnosed neuromuscular symptoms will be targeted via social media paid advertisements to recruit them to our study landing page (weblink: https://bit.ly/unearthrootcause). Two assessment tools were developed by the study team: the Impact of Daily Living (IDL) Survey and the MG Exercise Assessment. Both tools were designed using supporting literature, accepted guidelines, and a rigorous review via a panel of practicing neurologist key opinion leaders experienced in treating MG patients.
Adult participants who don't have specific diagnosed neurologic conditions will first be screened for eligibility based on the results of the IDL survey which will query participants on the presence or absence of habits/symptoms characteristic of MG. Those who qualify will complete the MG Exercise Assessment in which participants are provided video instructions to perform a series of 10 physical tests to examine if specific muscle groups undergo inducible fatigue. The results of the MG Exercise Assessment are reviewed by a neurologist to determine if participants would benefit further from an in-person neurologist evaluation for MG by a provider. Each participant is provided with a report of the neurologist's evaluation. Participants will be followed for 1 year through bimonthly communications to determine if and when they followed up with a clinician and if they received a confirmed diagnosis of myasthenia gravis.
324 studies on the registry are indexed under Myasthenia Gravis; 146 are open to participants now.
This study's enrollment of 215 is above the median of 140 across 104 observational studies indexed under Myasthenia Gravis.
Browse Myasthenia Gravis studies →ZS Associates is the lead sponsor of 2 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Adult participants who have undiagnosed neuromuscular symptoms
Exclusion Criteria:
Behavioral: Social media recruitment · Behavioral: Self-Assessment · Behavioral: Follow-up
Social media users exposed to a variety of paid social media advertisements as a recruitment tool for study enrollment
Eligible participants are asked to complete self-administered physical tests to assess inducible fatigue of specific muscle groups
Patients triaged based on their assessed risk of MG are asked to complete recommended follow-up with a clinician to determine presence of myasthenia gravis
Social media recruitment feasibility
Measure the engagement and feasibility metrics of the social media campaign
Time frame: Enrollment period (4-6weeks)
MG Exercise Assessment Tool validity
Estimate preliminary measures of validity for the MG Exercise Assessment Tool
Time frame: 1 year from time of enrollment
Time to diagnosis
Evaluate the time to diagnosis for any participant who has a confirmed diagnosis of MG after the completion of the study compared to that reported in literature
Time frame: 1 year from time of enrollment
This study is completed, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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