CClinicalTrials.gg
RecruitingNCT06378632DETECT-HFUpdated Mar 26, 2025

AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

An observational study in Heart Failure, sponsored by Cordio Medical. Recruiting at 45 sites in 3 countries. Open to participants aged 22 Years and older. Per ClinicalTrials.gov, last updated 2025-03-26.

Sponsored by Cordio Medical · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
500
Ages
22 Years and older
Sex
All
01

Study summary

Study Design:

This is an international, multicenter, observational, non-interventional, prospective, blinded, single-arm, two-period study, to collect patient utterances that will be retrospectively analyzed to determine the sensitivity and UPNR of the HearO system.

Read the detailed description

Two periods:

Run-In period will be a period in which patients will submit daily recordings, baseline creation

Core period will be a period in which patients will be followed up and will continually submit daily recordings for up-to 24 months per patient or until End-of-Study (EOS), whichever comes first.

02

Conditions studied

  • Heart Failure

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03

Who can participate

Ages eligible
22 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Outpatient clinics

Eligibility criteria

Major Inclusion Criteria:

  1. Age 22 or greater
  2. Diagnosed with Symptomatic Chronic Heart Failure [NYHA II-IVa (ambulatory)]
  3. At least one of the following:

    1. One ADHF hospitalization in the last 12 months
    2. One unplanned IV/SC diuretic administration in the last 6 months
    3. Two unplanned IV/SC diuretic administrations in the last 12 months
    4. NTProBNP >500 pg/ml
  4. Clinically stable HF according to investigator discretion
  5. Willing to participate as evidenced by signing the written informed consent.

Major Exclusion Criteria:

  1. Unable to comply with daily use of the App,
  2. Has had a major cardiovascular event within 3 months prior to enrolment.
  3. Had a Cardiac Resynchronization Therapy Device (CRT) implanted or upgrading ≤ 1 month prior to screening visit.
  4. Has estimated Glomerular Filtration Rate (eGFR) \< 30 ml/min/1.73.
  5. Is likely to undergo heart transplantation/ LVAD within 6 months of Screening Visit.
  6. Was treated for a significant COPD
04

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
500 participants (estimated)
Patient registry
No

Interventions

  • DeviceHearo App

    No intervention - only data collection

05

What researchers measure

Primary outcomes

  1. Heart Failure Events (HFEs)

    Until the end of the study, each participant will be assigned to one of the following event outcomes: 1. Having at least one protocol-defined Heart Failure Event (HFE) in the CORE period 2. Having no Heart Failure Event (HFE) during the entire CORE period

    Time frame: EOS is defined as when a total of at least 78 first usable and CEC-adjudicated HFEs have occurred or up-to 24 months per patient

06

Study locations

45 of 45 sites recruiting
  • Eastern Shore Research Institute
    Fairhope, Alabama 36532, United States
    Recruiting
  • UC San Diego Health
    La Jolla, California 92037, United States
    • Joshua Gillman, SC · Contact · j1gillman@health.ucsd.edu · (858) 246-2511
    • Nicholas Wettersten, MD · Principal investigator
    Recruiting
  • VA Loma Linda Healthcare System
    Loma Linda, California 92357, United States
    • Vicki Simpson, SC · Contact · vicki.simpson@va.gov · (909) 593-6361
    • Jay Patel, MD · Principal investigator
    Recruiting
  • VA San Diego
    San Diego, California 92161, United States
    • Jonathan Narita, SC · Contact · jonathan.narita@va.gov · (858) 642-3512
    • Nancy Gardetto, MD · Principal investigator
    Recruiting
  • University of California, San Francisco
    San Francisco, California 94117, United States
    Recruiting
  • Kaiser Permanente San Francisco
    San Francisco, California 94118, United States
    • Priscilla Chung, SC · Contact · priscilla.s.chung@kp.org · (415) 833-3480
    • Jana Svetlichanaya, MD · Principal investigator
    Recruiting
  • Nature Coast Clinical Research
    Crystal River, Florida 34429, United States
    • Nina Smith, SC · Contact · nsmith@encoredocs.com · (352) 563-1865
    • Susan Pasupuleti, MD · Principal investigator
    Recruiting
  • Jacksonville Center for Clinical Research
    Jacksonville, Florida 32216, United States
    • Taylor Johnson, SC · Contact · tjohnson@encoredocs.com · (904) 730-0101
    • Michael Koren, MD · Principal investigator
    Recruiting
  • Amavita Clinical Research
    Miami, Florida 33137, United States
    Recruiting
  • Advance Medical Research Services Corp (AMRS)
    Miami, Florida 33173, United States
    • Adam Rachid, SC · Contact · arachid.amrs@gmail.com · (305) 928-8845
    • Yordan Orive Gomez, MD · Principal investigator
    Recruiting
  • Baptist Health (Miami Cardiac & Vascular Institute)
    Miami, Florida 33173, United States
    Recruiting
  • Comprehensive Medical & Research Center
    Plantation, Florida 33317, United States
    Recruiting
  • St. Johns Center for Clinical Research
    St. Augustine, Florida 32086, United States
    • Valerie Hayes, SC · Contact · vhayes@encoredocs.com · (904) 209-0043
    • Ameeth Vedre, MD · Principal investigator
    Recruiting
  • Tampa General Hospital
    Tampa, Florida 33606, United States
    • Kiria Almeida-Tamayo, SC · Contact · kalmeidatamayo@tgh.org · (813) 844-8058
    • Debbie Hoffman, MD · Principal investigator
    Recruiting
  • West Georgia Cardiology
    Carrollton, Georgia 30117, United States
    Recruiting
  • University of Chicago
    Chicago, Illinois 60637, United States
    Recruiting
  • Advocate Illinois Masonic Medical Center
    Chicago, Illinois 60657, United States
    • Maci Eiber, SC · Contact · maci.eiber@aah.org · (773) 296-0969
    • Sorin Danciu, MD · Principal investigator
    Recruiting
  • Advocate Illinois Masonic Health Center
    Downers Grove, Illinois 60515, United States
    Recruiting
  • Midwest Cardiovascular Center
    Naperville, Illinois 60540, United States
    • Josilyn Klimek, SC · Contact · josilyn.klimek@cardio.com · (630) 600-0730
    • Maria Rosa Costanzo, MD · Principal investigator
    Recruiting
  • Robert J. Dole VA Medical Center
    Wichita, Kansas 67218, United States
    • Deborah Garner, sc · Contact · deborah.garner@va.gov · (316) 685-2221
    • Freidy Eid, MD · Principal investigator
    Recruiting
  • St. Elizabeth Healthcare
    Edgewood, Kentucky 41017, United States
    Recruiting
  • Cardiovascular Institute of the South
    Houma, Louisiana 70360, United States
    Recruiting
  • Cardiovascular Institute of the South
    Lafayette, Louisiana 70503, United States
    • June Jones, SC · Contact · june.jones@cardio.com · (337) 289-8429
    • Wade May, MD · Principal investigator
    Recruiting
  • University Medical Center New Orleans
    New Orleans, Louisiana 70112, United States
    Recruiting
  • Nebraska Heart Center
    Lincoln, Nebraska 68526, United States
    Recruiting
  • VA Southern Nevada Healthcare System
    North Las Vegas, Nevada 89086, United States
    • Rosalinda Cruz, SC · Contact · Rosalinda.cruz@va.gov · (702) 791-9000
    • Marriyam Moten, MD · Principal investigator
    Recruiting
  • Mount Sinai Morningside
    New York, New York 10025, United States
    Recruiting
  • The Mount Sinai Hospital
    New York, New York 10029, United States
    Recruiting
  • St. Francis Hospital
    Roslyn, New York 11576, United States
    • Lyn Santiago, SC · Contact · lyn.santiago@chsli.org · (516) 562-6763
    • Rita Jermyn, MD · Principal investigator
    Recruiting
  • Mission Hospital
    Asheville, North Carolina 28803, United States
    Recruiting
  • Moses H. Cone Memorial Hospital
    Greensboro, North Carolina 27401, United States
    Recruiting
  • The Lindner Research Center at The Christ Hospital
    Cincinnati, Ohio 45219, United States
    Recruiting
  • Cleveland Clinic
    Cleveland, Ohio 44106, United States
    • Savi Radesic · Contact · radesis@ccf.org · (216) 445-6916
    • W.H. Wilson Tang, MD · Principal investigator
    Recruiting
  • The Ohio State University
    Columbus, Ohio 43210, United States
    Recruiting
  • Vanderbilt University Medical Center
    Nashville, Tennessee 37232, United States
    • Terry Weyand, SC · Contact · terry.l.weyand@vumc.org · (615) 322-9349
    • JoAnn Lindenfeld, MD · Principal investigator
    Recruiting
  • Rio Grande Regional Hospital
    McAllen, Texas 78503, United States
    Recruiting
  • Methodist Hospital of San Antonio
    San Antonio, Texas 78229, United States
    Recruiting
  • University Hospital Samson Assuta Ashdod
    Ashdod, Israel
    • Sapir Swisa, SC · Contact
    • Alexander Goldman, MD · Principal investigator
    Recruiting
  • Assuta Be'er Sheva Medical Center
    Be'er Sheva, Israel
    • Alex Demitriev, SC · Contact
    • Amos Katz, MD · Principal investigator
    Recruiting
  • Rambam Medical Center
    Haifa, Israel
    • Ludmila Helmer, SC · Contact · 972-4-7773475
    • Oren Caspi, MD · Principal investigator
    Recruiting
  • Shaare Zedek Medical Center
    Jerusalem, Israel
    • Hadas Barda, SC · Contact · 972-2-6666769
    • Tal Hasin, MD · Principal investigator
    Recruiting
  • Galiee Medical Center
    Nahariya, Israel
    • Etti Lasri Kadosh, SC · Contact · 972-4-9107747
    • Shaul Atar, MD · Principal investigator
    Recruiting
  • Tel Aviv Sourasky (Ichilov) Medical Center
    Tel Aviv, Israel
    • Tal Fux, SC · Contact · 972-3-6972420
    • Michal Laufer Perl, MD · Principal investigator
    Recruiting
  • Poriya Medical Center
    Tiberias, Israel
    • Jannat Mukari, SC · Contact · 972-4-6652201
    • Wadi Kinany, MD · Principal investigator
    Recruiting
  • Hospital Universitari Germans Trias i Pujol
    Badalona, 08916, Spain
    • Paloma Gastelurrutia, SC · Contact · pgastelurrutia@gmail.com · 0034 930 330 521
    • Antoni Bayes-Genis, MD · Principal investigator
    Recruiting
07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT06378632
Lead sponsor
Cordio Medical
Responsible party
Sponsor
First posted
Apr 22, 2024
Start date
Feb 11, 2022
Primary completion
Jul 1, 2025 (estimated)
Completion
Jul 15, 2025 (estimated)
Last update
Mar 26, 2025

Study contacts

Bill Tobin
Contact
billt@ihcresearch.com
(203) 852-8900
Ronit Haviv, PhD
study director · Cordio Medical

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

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